Patents by Inventor Di-Hwei Hsu

Di-Hwei Hsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mammalian receptors for interleukin-10
    Patent number: 6423500
    Abstract: Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: July 23, 2002
    Assignee: Schering Corporation
    Inventors: Kevin W. Moore, Ying Liu, Alice Suk-Yue Ho, Di-Hwei Hsu, Bazan Fernando J., Jimmy C. Tan, Chuan-Chu Chou
  • Mammalian receptors for interleukin-10 (IL-10)
    Patent number: 5985828
    Abstract: Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 16, 1999
    Assignee: Schering Corporation
    Inventors: Kevin W. Moore, Ying Liu, Alice Suk-Yue Ho, Di-Hwei Hsu, J. Fernando Bazan, Jimmy C. Tan, Chuan-Chu Chou
  • Antibodies which specifically bind mammalian receptors for interleukin-10 (IL-10)
    Patent number: 5863796
    Abstract: Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 26, 1999
    Assignee: Schering Corporation
    Inventors: Kevin W. Moore, Ying Liu, Alice Suk-Yue Ho, Di-Hwei Hsu, J. Fernando Bazan, Jimmy C. Tan, Chuan-Chu Chou
  • Use of an interleukin-10 antagonist to treat a B cell mediated autoimmune disorder
    Patent number: 5837232
    Abstract: A method is provided for toting a B cell mediated autoimmune disorder comprising administering an effective amount of an interleukin-10 antagonist.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 17, 1998
    Assignee: Schering Corporation
    Inventors: Rene De Waal Malefyt, Maureen Howard, Di-Hwei Hsu, Hiroshi Ishida, Anne O'Garra, Hergen Spits, Albert Zlotnik
  • Use of interleukin-10 analogs for antagonists to treat endotoxin- or superantigen-induced toxicity
    Patent number: 5837293
    Abstract: A method is provided for reducing an inflammatory response in a mammal comprising administering to a mammal at risk of developing or afflicted with an inflammatory response characterized by substantially elevated levels of IL-1.alpha., IL-1.beta., IL-6, IL-8 and TNF.alpha., an amount of IL-10 effective to substantially lower the levels of such cytokines.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 17, 1998
    Assignee: Schering Corporation
    Inventors: Rene De Waal Malefyt, Maureen Howard, Di-Hwei Hsu, Hiroshi Ishida, Anne O'Garra, Hergen Spits, Albert Zlotnik
  • Use of interleukin-10 (IL-10) to treat endotoxin- or superantigen-induced toxicity
    Patent number: 5833976
    Abstract: A method is provided for treating septic shock or toxic shock that comprises administering an effective amount of interleukin-10.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: November 10, 1998
    Assignee: Schering Corporation
    Inventors: Rene de Waal Malefyt, Maureen Howard, Di-Hwei Hsu, Hiroshi Ishida, Anne O'Garra, Hergen Spits, Albert Zlotnik
  • Mammalian receptors for interleukin-10 (IL-10)
    Patent number: 5789192
    Abstract: Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
    Type: Grant
    Filed: August 23, 1993
    Date of Patent: August 4, 1998
    Assignee: Schering Corporation
    Inventors: Kevin W. Moore, Ying Liu, Alice Suk-Yue Ho, Di-Hwei Hsu, J. Fernando Bazan, Jimmy C. Tan, Chuan-Chu Chou
  • Use of interleukin-10 in adoptive immunotherapy of cancer
    Patent number: 5776451
    Abstract: A method is provided for using interleukin-10 in adoptive immunotherapy of cancer. A population of tumor-infiltrating lymphocytes (TILs) are expanded in culture in the presence of interleukin-2 (IL-2) and interleukin-10 (IL-10). After administration of the TILs to a patient, effective amounts of both IL-2 and IL-10 are administered to enhance the tumor cell cytoxicity of the TILs and to reduce side effects caused by IL-2-induced cytokine production in the TILs and other cells of the patient.
    Type: Grant
    Filed: July 5, 1994
    Date of Patent: July 7, 1998
    Assignee: Schering Corporation
    Inventors: Di-Hwei Hsu, Kevin W. Moore, Hergen Spits