Abstract: Customizable split kits are provided including a plurality of components that may be assembled into a waterproof and breathable wrist splint. The splint assembled from the kit can fit multiple size/shaped arms or other appendages, is moldable for custom positioning, protective, immobilizing, and locks-on for compliance.

Abstract: A customizable fitted device for immobilizing injuries and a method for constructing the fitted device is provided. The fitted device can be used to stabilize an arm, wrist, hand, leg, knee, ankle, foot or other body parts through custom formation. The device can be formed by a sidewall having one or more sidewall sections that can be secured together using retaining clips positioned within retaining clip slots on the device. The device can further include one or more openings defined in the sidewall of each device section while maintaining rigidity in the sidewall. The device can be constructed by of creating a 3D image scan of the particular body part on which the device will be applied, creating a design of the device to precisely match the contours of the 3D image scan, and using a 3D printer to construct the device according to the design.

Abstract: A facemask is provided that is made from a clear thermoplastic polymer with a sufficiently low glass transition temperature that a customer may engage in post-sale customization of the facemask. The facemask is configured to be heated and then reshaped by the customer, so as to better fit the customer's face. The facemask may include filter cavities or filter adaptors that conveniently hold removable filters. Methods of manufacturing a set of a plurality of facemasks, matching a customer to an appropriately sized facemask, and then enabling the customer to engage in post-sale customization are also provided.

Abstract: A customizable fitted device for immobilizing injuries and a method for constructing the fitted device is provided. The fitted device can be used to stabilize an arm, wrist, hand, leg, knee, ankle, foot or other body parts through custom formation. The device can be formed by a sidewall having one or more sidewall sections that can be secured together using retaining clips positioned within retaining clip slots on the device. The device can further include one or more openings defined in the sidewall of each device section while maintaining rigidity in the sidewall. The device can be constructed by of creating a 3D image scan of the particular body part to which the device will be applied, creating a design of the device to precisely match the contours of the 3D image scan, and using a 3D printer to construct the device according to the design.

Abstract: A customizable fitted device for immobilizing injuries and a method for constructing the fitted device is provided. The fitted device can be used to stabilize an al 1, wrist, hand, leg, knee, ankle, foot or other body parts through custom formation. The device can be formed by a sidewall having one or more sidewall sections that can be secured together using retaining clips positioned within retaining clip slots on the device. The device can further include one or more openings defined in the sidewall of each device section while maintaining rigidity in the sidewall. The device can be constructed by of creating a 3D image scan of the particular body part in which the device will be applied, creating a design of the device to precisely match the contours of the 3D image scan, and using a 3D printer to construct the device according to the design.

Abstract: The present invention concerns a method of detecting the presence of a DNA minor contributor in a DNA mixture by determining several haplotypes present in said one or more DNA samples.

Abstract: The present invention concerns Vgll3 a new target involved in adipogenesis modulation. Further, the present invention relates to methods to increase Vgll3 activity in adipocytes and preadipocytes. In addition, pharmaceutical composition comprising Vgll3 activity enhancing molecules in order to enhance the Vgll3 activity in a target tissue are also provided. These methods, compositions and molecules can be useful to modulate adipogenesis and thus treat obesity and related disorders.

Abstract: The present invention concerns Zdhhc2, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Zdhhc2 activity in adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Zdhhc2 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.

Abstract: The present invention concerns Vgll3 a new target involved in adipogenesis modulation. Further, the present invention relates to methods to increase Vgll3 activity in adipocytes and preadipocytes. In addition, pharmaceutical composition comprising Vgll3 activity enhancing molecules in order to enhance the Vgll3 activity in a target tissue are also provided. These methods, compositions and molecules can be useful to modulate adipogenesis and thus treat obesity and related disorders.

Abstract: The present invention concerns Zdhhc2, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Zdhhc2 activity in adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Zdhhc2 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.

Abstract: The present invention concerns Sipa1l1, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Sipa1l1 activity in preadipocytes and adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Sipa1l1 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.

Abstract: The present invention concerns a method of detecting the presence of a DNA minor contributor in a DNA mixture by determining several haplotypes present in said one or more DNA samples.

Abstract: The present invention concerns Sipa1l1, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Sipa1l1 activity in preadipocytes and adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Sipa1l1 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.

Abstract: Infant accommodation apparatus supported in normal use on a flat horizontal surface. The apparatus includes a support device having, in a vertical plane, a constant circular or oval-shaped cross-section along its extent. The support device has an inner enclosure wall which is an inwardly facing upstanding enclosure wall which defines an infant accommodation region in which an infant may be positioned in use. The inner enclosure wall is endless and defines an endless non-circular enclosure around the infant accommodation region. The maximum diameter of the infant accommodation region is in the range 20 to 50cm, and the inner enclosure wall includes, when viewed from above, three curved apex regions separated by curved side regions. The support device further includes an outer enclosure wall which is an outwardly facing upstanding enclosure wall. The outer enclosure wall, when viewed from above, is non-circular and symmetrical about each of three vertical planes angled at 120° to each other.

Abstract: The present invention concerns Zdhhc2, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Zdhhc2 activity in adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Zdhhc2 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.

Abstract: The present invention concerns Vgll3 a new target involved in adipogenesis modulation. Further, the present invention relates to methods to increase Vgll3 activity in adipocytes and preadipocytes. In addition, pharmaceutical composition comprising Vgll3 activity enhancing molecules in order to enhance the Vgll3 activity in a target tissue are also provided. These methods, compositions and molecules can be useful to modulate adipogenesis and thus treat obesity and related disorders.

Abstract: The present invention concerns Plac8, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Plac8 activity in preadipocytes and adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Plac8 activity as well screening test for identification of modulators as of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.

Abstract: An infant accommodation apparatus 2 comprises an inflatable support 4 and a framework 6 which abuts and extends over the device and includes toys arranged to stimulate an infant accommodated within an accommodation region 7 of the device. The support device has respective parallel inner and outer walls 13, 14 in the shape of modified equilateral triangles. Thus, the outer wall 14 of the member 8 may be regarded as being of a modified triangular shape having three curved apex regions 20 each of which has a radius of curvature which is less than the radius of curvature of the outer wall at positions between the apex region 20.

Abstract: The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc., in genes encoding an EGR molecule or an EGR interacting molecule, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by perfoming the screens.