Patents by Inventor Diana L. Nersesian

Diana L. Nersesian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indole and indoline derivatives and methods of use thereof
    Patent number: 9625475
    Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: April 18, 2017
    Assignee: AbbVie Inc.
    Inventors: Michael R. Schrimpf, Chih-Hung Lee, Tao Li, Gregory A. Gfesser, Kathleen H. Mortell, Ramin Faghih, Diana L. Nersesian, Kevin B. Sippy, William H. Bunnelle, Marc Scanio, Lei Shi, Murali Gopalakrishnan, Diana L. Donnelly-Roberts, Min Hu
  • INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20150353550
    Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
    Type: Application
    Filed: May 18, 2015
    Publication date: December 10, 2015
    Inventors: Michael R. Schrimpf, Chih-Hung Lee, Tao Li, Gregory A. Gfesser, Kathleen H. Mortell, Ramin Faghih, Diana L. Nersesian, Kevin B. Sippy, William H. Bunnelle, Marc Scanio, Lei Shi, Murali Gopalakrishnan, Diana L. Donnelly-Roberts, Min Hu
  • Indole and indoline derivatives and methods of use thereof
    Patent number: 9063126
    Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: June 23, 2015
    Assignee: AbbVie Inc.
    Inventors: Michael R. Schrimpf, Chih-Hung Lee, Tao Li, Gregory A. Gfesser, Kathleen H. Mortell, Ramin Faghih, Diana L. Nersesian, Kevin B. Sippy, William H. Bunnelle, Marc Scanio, Lei Shi, Murali Gopalakrishnan, Diana L. Donnelly-Roberts, Min Hu
  • AZAADAMANTANE DERIVATIVES AND METHODS OF USE
    Publication number: 20150158867
    Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Application
    Filed: February 17, 2015
    Publication date: June 11, 2015
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Kevin B. Sippy, Jianguo Ji, Tao Li, Marc Scanio, Lei Shi, Chih-Hung Lee, William H. Bunnelle, Geoff G.Z. Zhang, Paul J. Brackemeyer, Shuang Chen, Rodger F. Henry
  • Azaadamantane derivatives and methods of use
    Patent number: 8987453
    Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: March 24, 2015
    Assignee: AbbVie Inc.
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Kevin B. Sippy, Jianguo Ji, Tao Li, Marc Scanio, Lei Shi, Chih-Hung Lee, William H. Bunnelle, Geoff G. Z. Zhang, Paul J. Brackemeyer, Shuang Chen, Rodger F. Henry
  • Amino-aza-adamantane derivatives and methods of use
    Patent number: 8586746
    Abstract: The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding affinity to ?7 nicotinic acetylcholine receptors also are described.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: November 19, 2013
    Assignee: AbbVie Inc.
    Inventors: Michael R. Schrimpf, Kevin B. Sippy, David J. Anderson, William H. Bunnelle, Diana L. Nersesian
  • Amide derivatives as positive allosteric modulators and methods of use thereof
    Patent number: 8536221
    Abstract: The invention relates to novel amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: September 17, 2013
    Assignee: AbbVie Inc.
    Inventors: Kathleen H. Mortell, Diana L. Nersesian, Michael R. Schrimpf, Chih-Hung Lee, Murali Gopalakrishnan
  • Azaadamantane derivatives and methods of use
    Patent number: 8314119
    Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: November 20, 2012
    Assignee: AbbVie Inc.
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Kevin B. Sippy, Jianguo Ji, Tao Li, Marc Scanio, Lei Shi, Chih-Hung Lee, William H. Bunnelle, Geoff G. Z. Zhang, Paul J. Brackemeyer, Shuang Chen, Rodger F. Henry
  • Bicyclic-substituted amines as histamine-3 receptor ligands
    Patent number: 8273767
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: September 25, 2012
    Assignee: Abbott Laboratories
    Inventors: Robert J. Altenbach, Lawrence A. Black, Sou-Jen Chang, Marlon D. Cowart, Ramin Faghih, Gregory A. Gfesser, Yi-Yin Ku, Huaqing Liu, Kirill A. Lukin, Diana L. Nersesian, Yu-ming Pu, Padam N. Sharma, Youssef L. Bennani, Michael P. Curtis
  • 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
    Patent number: 8268853
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders ameliorated by ?4?2 positive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: September 18, 2012
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Chih-Hung Lee, Ramin Faghih, Gregory A. Gfesser
  • AZAADAMANTANE ESTER AND CARBAMATE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20120190704
    Abstract: The invention relates to compounds that are substituted azaadamantane ester and carbamate derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.
    Type: Application
    Filed: March 23, 2012
    Publication date: July 26, 2012
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Kevin B. Sippy, Jianguo Ji, Tao Li, Lei Shi
  • Azaadamantane ester and carbamate derivatives and methods of use thereof
    Patent number: 8163916
    Abstract: The invention relates to compounds that are substituted azaadamantane ester and carbamate derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: April 24, 2012
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Kevin B. Sippy, Jianguo Ji, Tao Li, Lei Shi
  • Amide derivatives as positive allosteric modulators and methods of use thereof
    Patent number: 7994223
    Abstract: The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: August 9, 2011
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Kathleen H. Mortell, Diana L. Nersesian, Chih-Hung Lee, Bruce Clapham
  • Amino-Aza-Adamantane Derivatives and Methods of Use
    Publication number: 20110118301
    Abstract: The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding affinity to ?7 nicotinic acetylcholine receptors also are described.
    Type: Application
    Filed: January 24, 2011
    Publication date: May 19, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael R. Schrimpf, Kevin B. Sippy, David J. Anderson, William H. Bunnelle, Diana L. Nersesian
  • BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS
    Publication number: 20110098285
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Application
    Filed: August 3, 2010
    Publication date: April 28, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Robert J. Altenbach, Lawrence A. Black, Sou-Jen Chang, Marlon D. Cowart, Ramin Faghih, Gregory A. Gfesser, Yi-Yin Ku, Huaqing Liu, Kirill A. Lukin, Diana L. Nersesian, Yu-ming Pu, Padam N. Sharma, Youssef L. Bennani, Michael P. Curtis
  • Amino-aza-adamantane derivatives and methods of use
    Patent number: 7897766
    Abstract: The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding affinity to ?7 nicotinic acetylcholine receptors also are described.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: March 1, 2011
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Kevin B. Sippy, David J. Anderson, William H. Bunnelle, Diana L. Nersesian
  • Substituted diazabicycloalkane derivatives having affinity for nicotinic acetylcholine receptors
    Patent number: 7872010
    Abstract: Provided herein are compositions of a class of substituted diazabicycloalkane derivative compounds, which are useful as modulators of nicotinic acetylcholine receptors. The compounds are useful in treating conditions and disorders prevented by, or ameliorated by, nicotinic acetylcholine receptors.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: January 18, 2011
    Assignee: Abbott Laboratories
    Inventors: Jennifer M. Frost, Jianguo Ji, Tao Li, Diana L. Nersesian, Karin R. Tietje
  • 3,9-DIAZASPIRO[5,5]UNDECANE AMIDES AND UREAS AND METHODS OF USE THEREOF
    Publication number: 20100331353
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders ameliorated by ?4?2 postive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
    Type: Application
    Filed: June 25, 2010
    Publication date: December 30, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Chih-Hung Lee, Ramin Faghih, Gregory A. Gfesser
  • AMIDE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20100286109
    Abstract: The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
    Type: Application
    Filed: July 22, 2010
    Publication date: November 11, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael R. Schrimpf, Kathleen H. Mortell, Diana L. Nersesian, Chih-Hung Lee, Bruce Clapham
  • INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20100249105
    Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
    Type: Application
    Filed: March 19, 2010
    Publication date: September 30, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael R. Schrimpf, Chih-Hung Lee, Tao Li, Gregory A. Gfesser, Kathleen H. Mortell, Ramin Faghih, Diana L. Nersesian, Kevin B. Sippy, William H. Bunnelle, Marc Scanio, Lei Shi, Murali Gopalakrishnan, Diana L. Donnelly-Roberts, Min Hu