Patents by Inventor Diana Velluto
Diana Velluto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220168448Abstract: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is enclosed or decoded based on the generated parity-check matrix.Type: ApplicationFiled: July 2, 2021Publication date: June 2, 2022Inventors: Jeffrey A. HUBBELL, Conlin P. O'NEIL, Melody SWARTZ, Diana VELLUTO, André Van Der Vlies
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Patent number: 10711106Abstract: The present invention features linear and three-dimensional supramolecular materials self-assembled from block co-polymers comprising oligo(ethylene sulfide) (OES). The block copolymers assemble into fibrils, micelles, or matrices. The fibrillar materials are sensitive to oxidation, which leads to decreased OES block hydrophobicity and crystallinity, and increased water solubility of the polymer constituents. Molecular loading options, coupled with oxidative sensitivity, allow implantable or injectable fibrillar suspensions or cross-linked three-dimensional matrices to demonstrate significant biomedical potential, especially in the context of extracellular and intracellular molecular delivery and applications related to infection and disease.Type: GrantFiled: July 24, 2014Date of Patent: July 14, 2020Assignee: The University of ChicagoInventors: Jeffrey A. Hubbell, Carrie E. Brubaker, Diana Velluto
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Publication number: 20200000936Abstract: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is enclosed or decoded based on the generated parity-check matrix.Type: ApplicationFiled: July 1, 2019Publication date: January 2, 2020Inventors: James Brandon DIXON, Jeffrey A. Hubbell, Conlin P. O'Neil, Melody Swartz, Diana Velluto
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Patent number: 10335499Abstract: Block copolymers containing charged blocks or chemical moieties sensitive to oxidation or hydrolysis have been developed. We describe the use of such block copolymers in supramolecular structures, e.g., micelles or vesicles, and pharmaceutical compositions and in methods of preparing the supramolecular structures and pharmaceutical compositions. The invention is particularly useful for the delivery of pharmaceutical agents, e.g., nucleic acids, to cells.Type: GrantFiled: February 5, 2016Date of Patent: July 2, 2019Assignee: École Polytechnique Fédérale de Lausanne (EPFL)Inventors: James Brandon Dixon, Jeffrey A. Hubbell, Conlin P. O'Neil, Melody Swartz, Diana Velluto
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Publication number: 20160256569Abstract: Block copolymers containing charged blocks or chemical moieties sensitive to oxidation or hydrolysis have been developed. We describe the use of such block copolymers in supramolecular structures, e.g., micelles or vesicles, and pharmaceutical compositions and in methods of preparing the supramolecular structures and pharmaceutical compositions. The invention is particularly useful for the delivery of pharmaceutical agents, e.g., nucleic acids, to cells.Type: ApplicationFiled: February 5, 2016Publication date: September 8, 2016Inventors: James Brandon DIXON, Jeffrey A. HUBBELL, Conlin P. O'NEIL, Melody SWARTZ, Diana VELLUTO
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Publication number: 20160177036Abstract: The present invention features linear and three-dimensional supramolecular materials self-assembled from block co-polymers comprising oligo(ethylene sulfide) (OES). The block copolymers assemble into fibrils, micelles, or matrices. The fibrillar materials are sensitive to oxidation, which leads to decreased OES block hydrophobicity and crystallinity, and increased water solubility of the polymer constituents. Molecular loading options, coupled with oxidative sensitivity, allow implantable or injectable fibrillar suspensions or cross-linked three-dimensional matrices to demonstrate significant biomedical potential, especially in the context of extracellular and intracellular molecular delivery and applications related to infection and disease.Type: ApplicationFiled: July 24, 2014Publication date: June 23, 2016Inventors: Jeffrey A. Hubbell, Carrie E. Brubaker, Diana Velluto
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Patent number: 9271929Abstract: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is encoded or decoded based on the generated parity-check matrix.Type: GrantFiled: November 24, 2009Date of Patent: March 1, 2016Assignee: École Polytechnique Fédérale de Lausanne (EPFL)Inventors: James Brandon Dixon, Jeffrey A. Hubbell, Conlin P. O'Neil, Melody Swartz, Diana Velluto
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Patent number: 8323696Abstract: Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics. Surface chemistries and chemical formulations for the nanoparticles are described.Type: GrantFiled: August 29, 2008Date of Patent: December 4, 2012Assignee: Ecole Polytechnique Federale de LausanneInventors: Jeffrey A. Hubbell, Conlin P. O'Neil, Sai T. Reddy, Melody A. Swartz, Diana Velluto, André van der Vlies, Eleonora Simeoni
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Publication number: 20110223217Abstract: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is encoded or decoded based on the generated parity-check matrix.Type: ApplicationFiled: November 24, 2009Publication date: September 15, 2011Applicant: Ecole Polytechnique Federale de Lausanne (EPFL)Inventors: James Brandon Dixon, Jeffrey A. Hubbell, Conlin P. O'Neil, Melody Swartz, Diana Velluto
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Publication number: 20100055189Abstract: Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics. Surface chemistries and chemical formulations for the nanoparticles are described.Type: ApplicationFiled: August 29, 2008Publication date: March 4, 2010Inventors: Jeffrey A. Hubbell, Conlin P. O'Neil, Sai T. Reddy, Melody A. Swartz, Diana Velluto, Andre van Der Vlies, Eleonora Simeoni