Patents by Inventor Diane H. Boschelli

Diane H. Boschelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclic protein kinase inhibitors
    Patent number: 7105531
    Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: September 12, 2006
    Assignee: WYETH
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Tricyclic protein kinase inhibitors
    Publication number: 20040110762
    Abstract: This invention provides compounds of formula 1, having the structure 1
    Type: Application
    Filed: July 10, 2003
    Publication date: June 10, 2004
    Applicant: WYETH
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Tricyclic protein kinase inhibitors
    Patent number: 6638929
    Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: October 28, 2003
    Assignee: Wyeth
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Tricyclic protein kinase inhibitors
    Publication number: 20010051620
    Abstract: This invention provides compounds of formula 1, having the structure 1
    Type: Application
    Filed: December 29, 2000
    Publication date: December 13, 2001
    Applicant: American Home Products Corporation
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
    Patent number: 5620981
    Abstract: 6-Aryl pyrido[2,3-d]pyrimidine 7-imines, 7-ones, and 7-thiones are inhibitors of protein tyrosine kinases, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: April 15, 1997
    Assignee: Warner-Lambert Company
    Inventors: Clifton J. Blankley, Diane H. Boschelli, Annette M. Doherty, James M. Hamby, Sylvester Klutchko, Robert L. Panek
  • Method of selectively inhibiting prostaglandin G/H synthase-2
    Patent number: 5571825
    Abstract: The present invention provides a method of selectively inhibiting prostaglandin G/H synthase-2 that comprises administering to a patient in need of such inhibition an inhibiting amount of a compound having the Formula I, II or III ##STR1## wherein the R groups and heterocycles are defined in the disclosure.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: November 5, 1996
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, Richard D. Dyer, Sonya S. Khatana, James B. Kramer, William H. Roark
  • Benzothiophene, benzofuran and indole-thiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of HIV
    Patent number: 5565446
    Abstract: Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as well as methods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases; these compounds also inhibit the activation of human immunodeficiency virus (HIV).
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: October 15, 1996
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, James B. Kramer, Paul C. Unangst
  • Method for treating inflammatory disease in humans
    Patent number: 5489586
    Abstract: Benzothiophene, benzofuran and indole-thiazepinones, oxazepinones and diazepinones as well as methods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: February 6, 1996
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, James B. Kramer, Paul C. Unangst
  • Fenamate 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as antiinflammatory agents
    Patent number: 5462952
    Abstract: The present invention is novel compounds which are 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, and pharamaceutically acceptable acid addition or base salts thereof having activity as inhibitors of singly or together 5-lipoxygenase and cyclooxygenase, and pharmaceutical compositions or methods of use therefor.
    Type: Grant
    Filed: September 8, 1993
    Date of Patent: October 31, 1995
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, Milton L. Hoefle
  • 1-ether and 1-thioether-naphthalene-2-carboxamides as inhibitors of cell adhesion and as inhibitors of the activation of HIV
    Patent number: 5434188
    Abstract: 1-Ether and 1-thioether-naphthalene-2-carboxamides are described, methods of manufacture therefor and their use as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases, and their utility in inhibiting the activation of human immunodeficiency virus (HIV), latent in infected humans.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: July 18, 1995
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, Sony S. Khatana, James B. Kramer, Paul C. Unangst
  • Indole-2-carboxamides as inhibitors of cell adhesion
    Patent number: 5424329
    Abstract: 3-Substituted-indole-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of manufacture are also described.Certain of the indole-2-carboxamides also inhibit the activation of human immunodeficiency virus (HIV), latent in infected humans.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: June 13, 1995
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, Paul C. Unangst
  • Benzylidene-lactone and their thiocarbonyl analogs as inhibitors of proteoglycan degradation
    Patent number: 5358964
    Abstract: The manufacture and use of compounds of the formula ##STR1## wherein Y is O or S, R.sub.1 is hydrogen or alkyl, and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are hydrogen or various substituent groups, and pharmaceutically acceptable acid addition salts thereof. The compounds have activity as inhibitors of the IL-I or other agonist-induced proteoglycan degradation in bovine nasal cartilage and pharmaceutical compositions containing such compounds are described to treat conditions advantageously affected by such inhibition including arthritis.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: October 25, 1994
    Assignee: Warner-Lambert Company
    Inventors: Vijaykumar Baragi, Diane H. Boschelli, David T. Connor, Richard R. Renkiewicz
  • 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [.beta.]thiophene-2-carboxamides as inhibitors of cell adhesion
    Patent number: 5356926
    Abstract: 3-Alkyloxy-, aryloxy-, or arylalkyloxybenzo[b]-thiophene-2-carboxamides are described as agents which block leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of preparation are also described.
    Type: Grant
    Filed: February 9, 1993
    Date of Patent: October 18, 1994
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, Clifford D. Wright
  • 3-thio or amino substituted-benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted-benzofuran-2-carboxamides as inhibitors of cell adhesion
    Patent number: 5350748
    Abstract: 3-Thio or amino substituted benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted benzofuran-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of manufacture are also described.The same benzo[b]thiophene and benzofuran-2-carboxamides also inhibit the activation of human immunodeficiency virus (HIV), latent in infected mammals.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: September 27, 1994
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, James B. Kramer, Paul C. Unangst
  • 3-[thiazolidinone, oxazolidinone, imidazolidinone]-indoles as antiinflammatory agents
    Patent number: 5250552
    Abstract: The present invention is for selected novel compounds which are 3-[thiazolidinone, oxazolidinone, imidazolidinone]-indoles as well as pharmaceutical compositions and methods of use thereof. These compounds have activity useful in treating allergies and inflammation.
    Type: Grant
    Filed: May 6, 1992
    Date of Patent: October 5, 1993
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor
  • 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo(b) thiophene-2-carboxamides as inhibitors of cell adhesion
    Patent number: 5208253
    Abstract: 3-Alkyloxy-, aryloxy-, or arylalkyloxy-benzo[b]thiophene-2-carboxamides are described as agents which block leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of preparation are also described.
    Type: Grant
    Filed: February 24, 1992
    Date of Patent: May 4, 1993
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, Clifford D. Wright
  • 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents
    Patent number: 5143929
    Abstract: The present invention is for selected novel compounds which are 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates, as well as pharmaceutical compositions and methods of use thereof. These compounds exhibit activity useful in treating allergies and inflammation.
    Type: Grant
    Filed: May 9, 1991
    Date of Patent: September 1, 1992
    Assignee: Warner-Lambert Company
    Inventors: Thomas R. Belliotti, Diane H. Boschelli, David T. Connor, Catherine R. Kostlan
  • 3-(thiazolidone, oxazolidinone, imidazolidinone)-indoles as antiinflammatory agents
    Patent number: 5143927
    Abstract: The present invention is for selected novel compounds which are 3-[thiazolidinone, oxazolidinone, imidazolidinone]-indoles as well as pharmaceutical compositions and methods of use thereof. These compounds have activity useful in treating allergies and inflammation.
    Type: Grant
    Filed: May 9, 1991
    Date of Patent: September 1, 1992
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor
  • 1,2,4-oxadiazole and 1,2,4-thiadiazole derivatives of fenamates as antiinflammatory agents
    Patent number: 5114958
    Abstract: 1,2,4-Oxadiazole and 1,2,4-thiadiazole derivatives of the fenamic acids, in which the fenamate residue is present at the 3-position of the 1,2,4-oxadiazole or 1,2,4-thiadiazole, pharmaceutically acceptable acid addition or base salts and methods of preparation for such compounds as well as pharmaceutical compositions alone or in combination with a second active ingredient are described. The compounds are active as inhibitors of cyclooxygenase and/or 5-lipoxygenase thereby providing methods of treatment for antiinflammatory diseases.
    Type: Grant
    Filed: May 9, 1991
    Date of Patent: May 19, 1992
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor
  • 3,5-ditertiarybutyl-4-hydroxyphenyl, 1,3,4-thiadiazoles and oxadiazoles linked by carbon, oxygen, and sulfur residues
    Patent number: 5102897
    Abstract: The novel 3,5-ditertiarybutyl-4-hydroxyphenylthio-1,3,4-thiadiazoles and oxadiazoles and 3,5-ditertiarybutyl-4-hydroxyphenylmethanone-1,3,4-thiadiazoles and oxadiazoles and related compounds of the present invention are antiinflammatory agents having activity as inhibitors of 5-lipoxygenase, cyclooxygenase or both.
    Type: Grant
    Filed: January 24, 1991
    Date of Patent: April 7, 1992
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, Catherine R. Kostlan, James B. Kramer, Michael D. Mullican, Jagadish C. Sircar