Abstract: This application describes a method of determining the amount of organic polyamine in an aqueous solution to be assayed, which comprises (1) incubating a measured volume of said solution with a solution containing a protein with glutamine residues and a small, known amount of radiolabeled polyamine, in the presence of transglutaminase, (2) placing aliquots of the incubated solution on thin layer chromatographic strips treated with aqueous acid, (3) treating said strips with dilute aqueous acid solution to cause ascending chromatography, (4) cutting from the strips the sections where the aliquots had been applied thereto, (5) counting the radioactive scintillations of said sections, (6) carrying out steps (1) through (5) with the same volume of a standard solution containing a known amount of said polyamine, and (7) calculating the amount of polyamine in the solution to be assayed from the scintillation count made in the test procedure thereon in comparison to the scintillation count made in the test procedure

Abstract: A process and pharmaceutical compositions for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc., comprising administering to humans or domesticated animals, topically and/or parenterally, and/or systemically a composition comprising a pharmaceutical carrier and at least one diamino compound selected from the diamines of saturated and unsaturated aliphatic hydrocarbons having 3 to 6 carbon atoms and the diamines of saturated monocarboxylic acids having 4 to 6 carbon atoms and the alkyl esters thereof containing from 1 to 4 carbon atoms. These diamino compounds are usable alone or in combination with certain prostaglandin compounds, certain phosphodiesterase inhibitor compounds and certain cyclic adenosine monophosphate compounds.

Abstract: A process and pharmaceutical compositions for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc., comprising administering to humans or domesticated animals, topically and/or parenterally, and/or systemically a composition comprising a pharmaceutical carrier and at least one diamino compound selected from the diamines of saturated and unsaturated aliphatic hydrocarbons having 3 to 6 carbon atoms and the diamines of saturated monocarboxylic acids having 4 to 6 carbon atoms and the alkyl esters thereof containing from 1 to 4 carbon atoms. These diamino compounds are usable alone or in combination with certain prostaglandin compounds, certain phosphodiesterase inhibitor compounds and certain cyclic adenosine monophosphate compounds.