Patents by Inventor Diane Pennica

Diane Pennica has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human tissue plasminogen activator
    Patent number: 5702938
    Abstract: Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 30, 1997
    Assignee: Genetech, Inc.
    Inventors: David V. Goeddel, William J. Kohr, Diane Pennica, Gordon A. Vehar
  • Gene encoding cardiac hypertrophy factor
    Patent number: 5679545
    Abstract: Isolated CT-1, isolated DNA encoding CT-1, and recombinant or synthetic methods of preparing CT-1 are disclosed. These CT-1 molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: October 21, 1997
    Assignees: Genentech, Inc., The Regents of the University of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Hybridomas producing antibodies to cardiac hypertrophy factor
    Patent number: 5627073
    Abstract: Isolated CHF (also referred to cardiac hypertrophy factor or cardiotrophin-1), isolated DNA encoding CHF, hybridomas and cell lines producing antibodies to CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: May 6, 1997
    Assignees: Genentech, Inc., The Regents of the University of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Antibodies to cardiac hypertrophy factor and uses thereof
    Patent number: 5624806
    Abstract: Isolated CHF, isolated DNA encoding cardiac hypertrophy factor (CHF), and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: April 29, 1997
    Assignees: Genentech, Inc., The Regents of the University of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Human tissue plasminogen activator
    Patent number: 5587159
    Abstract: Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.
    Type: Grant
    Filed: June 21, 1994
    Date of Patent: December 24, 1996
    Assignee: Genentech, Inc.
    Inventors: David V. Goeddel, William J. Kohr, Diane Pennica, Gordon A. Vehar
  • Detection and amplification of candiotrophin-1(cardiac hypertrophy factor)
    Patent number: 5571675
    Abstract: Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: November 5, 1996
    Assignees: Genentech, Inc., Regents of the Univ. of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Cardiac hypertrophy factor
    Patent number: 5571893
    Abstract: Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed, These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: November 5, 1996
    Assignees: Genentech, Inc., Regents of the Univ. of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Human tPA production using vectors coding for DHFR protein
    Patent number: 5424198
    Abstract: A method for producing tissue plasminogen activator (t-PA)in eukaroytic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate.
    Type: Grant
    Filed: December 3, 1993
    Date of Patent: June 13, 1995
    Assignee: Genentech, Inc.
    Inventors: Arthur D. Levinson, Diane Pennica, William J. Kohr, Gordon A. Vehar, David V. Goeddel, Elizabeth M. Yelverton, Christian C. Simonsen
  • Human t-PA production using vectors coding for DHFR protein
    Patent number: 5268291
    Abstract: A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: December 7, 1993
    Assignee: Genentech, Inc.
    Inventors: Arthur D. Levinson, Diane Pennica, William J. Kohr, Gordon A. Vehar, David V. Goeddel, Christian C. Simonsen
  • Truncated human tissue plasminogen activator
    Patent number: 5185259
    Abstract: Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed. A truncated human tissue plasminogen activator consisting essentially of amino acids 69-527 is produced using recombinant DNA techniques.
    Type: Grant
    Filed: March 2, 1990
    Date of Patent: February 9, 1993
    Assignee: Genentech, Inc.
    Inventors: David V. Goeddel, William J. Kohr, Diane Pennica, Gordon A. Vehar
  • Human tPA production using vectors coding for DHFR protein
    Patent number: 5011795
    Abstract: A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild type DHFR with methotrexate.
    Type: Grant
    Filed: March 22, 1990
    Date of Patent: April 30, 1991
    Assignee: Genentech, Inc.
    Inventors: Arthur D. Levinson, Diane Pennica, William J. Kohr, Gordon A. Vehar, David V. Goeddel, Elizabeth M. Yelverton, Christian C. Simonsen
  • Human tissue plasminogen activator
    Patent number: 4853330
    Abstract: Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.
    Type: Grant
    Filed: April 21, 1988
    Date of Patent: August 1, 1989
    Assignee: Genentech, Inc.
    Inventors: David V. Goeddel, William J. Kohr, Diane Pennica, Gordon A. Vehar
  • Human tissue plasminogen activator
    Patent number: 4766075
    Abstract: Human tissue phasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.
    Type: Grant
    Filed: April 7, 1983
    Date of Patent: August 23, 1988
    Assignee: Genentech, Inc.
    Inventors: David V. Goeddel, William J. Kohr, Diane Pennica, Gordon A. Vehar