Patents by Inventor Dianne Schwarz

Dianne Schwarz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING
    Publication number: 20200291396
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: February 24, 2020
    Publication date: September 17, 2020
    Inventors: Phillip D. ZAMORE, Gyorgy HUTVAGNER, Dianne SCHWARZ, Martin SIMARD
  • Methods and compositions for enhancing the efficacy and specificity of RNA silencing
    Patent number: 10604754
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: March 31, 2020
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. Zamore, Gyorgy Hutvagner, Dianne Schwarz, Martin Simard
  • METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF SINGLE AND DOUBLE BLUNT-ENDED siRNA
    Publication number: 20200024602
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides single and double-blunt ended siRNA compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: June 28, 2019
    Publication date: January 23, 2020
    Inventors: Phillip D. ZAMORE, Dianne SCHWARZ
  • Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
    Patent number: 10385339
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides single and double-blunt ended siRNA compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: August 20, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. Zamore, Dianne Schwarz
  • METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF SINGLE AND DOUBLE BLUNT-ENDED siRNA
    Publication number: 20180187194
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides single and double-blunt ended siRNA compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: December 7, 2017
    Publication date: July 5, 2018
    Inventors: Phillip D. ZAMORE, Dianne SCHWARZ
  • Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
    Patent number: 9879253
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides single and double-blunt ended siRNA compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: January 30, 2018
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. Zamore, Dianne Schwarz
  • Compositions for RNA interference and methods of use thereof
    Patent number: 9611472
    Abstract: The present invention provides compositions for RNA interference and methods of use thereof. In particular, the invention provides single-stranded small interfering RNAs. Functional and genomic and proteomic methods are featured. Therapeutic methods are also featured.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: April 4, 2017
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, Gyorgy Hutvagner, Dianne Schwarz, Guiliang Tang, Benjamin Haley
  • Methods and compositions for enhancing the efficacy and specificity of RNA silencing
    Patent number: 9121018
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: September 1, 2015
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, Gyorgy Hutvagner, Dianne Schwarz, Martin Simard
  • COMPOSITIONS FOR RNA INTERFERENCE AND METHODS OF USE THEREOF
    Publication number: 20140373188
    Abstract: The present invention provides compositions for RNA interference and methods of use thereof. In particular, the invention provides single-stranded small interfering RNAs. Functional and genomic and proteomic methods are featured. Therapeutic methods are also featured.
    Type: Application
    Filed: March 20, 2014
    Publication date: December 18, 2014
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. ZAMORE, Gyorgy HUTVAGNER, Dianne SCHWARZ, Guiliang TANG, Benjamin HALEY
  • METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING
    Publication number: 20140322813
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: June 3, 2014
    Publication date: October 30, 2014
    Inventors: Phillip D. ZAMORE, Gyorgy HUTVAGNER, Dianne SCHWARZ, Martin SIMARD
  • METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF SINGLE AND DOUBLE BLUNT-ENDED siRNA
    Publication number: 20140287491
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides single and double-blunt ended siRNA compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: May 6, 2014
    Publication date: September 25, 2014
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. ZAMORE, Dianne SCHWARZ
  • Compositions for RNA interference and methods of use thereof
    Patent number: 8729036
    Abstract: The present invention provides compositions for RNA interference and methods of use thereof. In particular, the invention provides single-stranded small interfering RNAs. Functional and genomic and proteomic methods are featured. Therapeutic methods are also featured.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: May 20, 2014
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, György Hutvágner, Dianne Schwarz, Guiliang Tang, Benjamin Haley
  • METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING
    Publication number: 20130309767
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: October 17, 2012
    Publication date: November 21, 2013
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. ZAMORE, Gyorgy HUTVAGNER, Dianne SCHWARZ, Martin SIMARD
  • METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF SINGLE AND DOUBLE BLUNT-ENDED siRNA
    Publication number: 20120322846
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides single and double-blunt ended siRNA compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: October 11, 2011
    Publication date: December 20, 2012
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. ZAMORE, Dianne SCHWARZ
  • Methods and compositions for enhancing the efficacy and specificity of RNA silencing
    Patent number: 8329892
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: December 11, 2012
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, Gyorgy Hutvagner, Dianne Schwarz, Martin Simard
  • Methods and compositions for enhancing the efficacy and specificity of RNA silencing
    Patent number: 8309705
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: November 13, 2012
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, Gyorgy Hutvagner, Dianne Schwarz, Martin Simard
  • Methods and compositions for enhancing the efficacy and specificity of RNAi
    Patent number: 8309704
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNAi. The invention also provides compositions for mediating RNAi. In particular, the invention provides siRNAs, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: November 13, 2012
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, Gyorgy Hutvagner, Dianne Schwarz, Martin Simard
  • Methods and compositions for enhancing the efficacy and specificity of RNA silencing
    Patent number: 8304530
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: November 6, 2012
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, Gyorgy Hutvagner, Dianne Schwarz, Martin Simard
  • METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING
    Publication number: 20100184828
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: March 29, 2010
    Publication date: July 22, 2010
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. ZAMORE, Gyorgy HUTVAGNER, Dianne SCHWARZ, Martin SIMARD
  • METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING
    Publication number: 20100184826
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: March 23, 2010
    Publication date: July 22, 2010
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. ZAMORE, Gyorgy HUTVAGNER, Dianne SCHWARZ, Martin SIMARD