Abstract: Fluidic coupling assemblies include a fitting body having a single integral piece or separable pieces such as male and female fittings such as luer fittings. The assemblies further comprise a rotatable fastening assembly having a drive collar and a driven member, and at least one resilient member having a spring bias that defines a threshold torque of the rotatable fastening assembly. The spring bias may be directed axially or radially with respect to the longitudinal axis of the fluidic coupling assembly. The resilient member is configured to prevent overtightening of the fluidic coupling assembly by allowing the drive collar to rotate the driven member only when less than a threshold torque is applied. Rotation of the rotatable fastening assembly imparts a compressive force on the resilient member, and the resilient member yields when the compressive force exceeds the spring bias of the resilient member.