Patents by Inventor Didier Van Broeck

Didier Van Broeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 2,5-dihydro-3H-pyrazolo[4,3-C]pyridazin-3-one derivatives, preparation thereof and therapeutic use of the same
    Patent number: 7915258
    Abstract: The invention relates to compounds having the formula (I): Wherein R1, R2, R3 and R4 are as described herein. Also disclosed are the method of preparation and their use in therapy.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: March 29, 2011
    Assignee: Sanofi-Aventis
    Inventors: Christian Congy, Victor Dos Santos, Murielle Rinaldi-Carmona, Arnaud Rouquette, Didier Van Broeck
  • (1,5-diphenyl-1-pyrazol-3-yl)oxadiazole derivatives, preparation method thereof and use of same in therapeutics
    Patent number: 7632852
    Abstract: The invention relates to compounds having formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to a method of preparing said compounds and to the application thereof in therapeutics.
    Type: Grant
    Filed: August 8, 2007
    Date of Patent: December 15, 2009
    Assignee: Sanofi-aventis
    Inventors: Francis Barth, Christian Congy, Patrick Gueule, Murielle Rinaldi-Carmona, Didier Van Broeck
  • SUBSTITUTED 2,5-DIHYDRO-3H-PYRAZOLO[4,3-C]PYRIDAZIN-3-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE OF THE SAME
    Publication number: 20090281107
    Abstract: The invention relates to compounds having the formula (I): Wherein R1, R2, R3 and R4 are as described herein. Also disclosed are the method of preparation and their use in therapy.
    Type: Application
    Filed: May 19, 2009
    Publication date: November 12, 2009
    Applicant: SANOFI-AVENTIS
    Inventors: Christian CONGY, Victor DOS SANTOS, Murielle RINALDI-CARMONA, Arnaud ROUQUETTE, Didier VAN BROECK
  • (1,5-DIPHENYL-1H-PYRAZOL-3-YL)OXADIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS
    Publication number: 20080039510
    Abstract: The invention relates to compounds having formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to a method of preparing said compounds and to the application thereof in therapeutics.
    Type: Application
    Filed: August 8, 2007
    Publication date: February 14, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Francis BARTH, Christian CONGY, Patrick GUEULE, Murielle RINALDI-CARMONA, Didier VAN BROECK
  • Novel human NK3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them
    Publication number: 20040220223
    Abstract: Compounds of formula (I), a method for obtaining them and pharmaceutical compositions containing them are described. The compounds are useful as human NK3 receptor antagonists.
    Type: Application
    Filed: March 22, 2004
    Publication date: November 4, 2004
    Inventors: Daniel Bichon, Xavier Emonds-Alt, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck
  • Human NK3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them
    Patent number: 6710042
    Abstract: Compounds of formula (I) are useful as human NK3 receptor antagonists.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: March 23, 2004
    Assignee: Sanofi-Synthelabo
    Inventors: Daniel Bichon, Xavier Edmonds-Alt, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck
  • Ureidopiperidine derivatives as selective human NK3 receptor antagonists
    Patent number: 6465489
    Abstract: The invention concerns compounds of formula (I) in racemic or optically pure form, methods for obtaining them and pharmaceutical compositions containing same. Said compounds are selective NK3 receptor antagonists.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: October 15, 2002
    Assignee: Sanofi-Synthelabo
    Inventors: Alain Aulombard, Xavier Emonds-Alt, Vincenzo Proietto, Didier Van Broeck
  • Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools
    Patent number: 6294537
    Abstract: A method for treating diseases which involve interaction of neurokinin B with NK3 receptors in humans. The method comprises administering a therapeutically effective amount of a NK3 antagonist compound having the formula: in which: R1 and R11 together represent a —(CH2)3-group.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: September 25, 2001
    Assignee: Sanofi-Synthelabo
    Inventors: Daniel Bichon, Patrick Gueule, Didier Van Broeck, Xavier Emonds-Alt, Vincenzo Proietto
  • Human NK3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them
    Patent number: 6291672
    Abstract: Compounds of the formula are useful as human NK3 receptor antagonists.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: September 18, 2001
    Assignee: Sanofi-Synthelabo
    Inventors: Daniel Bichon, Xavier Emonds-Alt, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck
  • Substituted heterocylic compounds, method of preparing them and pharmaceutical compositions in which they are present
    Patent number: 6242637
    Abstract: The invention relates to compounds of the formula in which: A is a divalent radical selected from: A1) —O—CO— A2) —CH2—O—CO— A3) —O—CH2—CO— A4) —O—CH2—CH2— A5) —N(R1)—CO— A6) —N(R1)—CO—CO— A7) —N(R1)—CH2—CH2— A8) —O—CH2— in which: R1 is a hydrogen or a (C1-C4)-alkyl; and Am is a nitrogen-containing heterocycle.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: June 5, 2001
    Assignee: Sanofi-Synthelabo
    Inventors: Xavier Emonds-Alt, Isabelle Grossriether, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck
  • Use of amines to produce drugs for preventing tumor cell proliferation
    Patent number: 6235791
    Abstract: The present invention relates to the use of compounds capable of displacing tritiated cis-N-cyclohexyl-N-ethyl [3-(3-chloro-4-cyclohexylphenyl)-allyl]amine from its receptors for the preparation of pharmaceutical compositions intended to combat cell proliferation.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: May 22, 2001
    Assignee: Sanofi-Synthelabo
    Inventors: Jean Claude Breliere, Pascual Ferrara, Christine Lebouteiller, Raymond Paul, Jorge Rosenfeld, Didier Van Broeck
  • Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools
    Patent number: 6124316
    Abstract: A compound of formula: ##STR1## in which: Ar represents a pyrid-2-yl or a phenyl which is unsubstituted or substituted by a halogen, a methyl or a (C.sub.1 -C.sub.4)alkoxy;R.sub.1 represents a methyl group;R.sub.11 represents hydrogen;or R.sub.1 and R.sub.11 together represent a --(CH.sub.2).sub.3 -- group;R.sub.2 represents a hydroxyl; a (C.sub.1 -C.sub.7)alkoxy; a (C.sub.1 -C.sub.7)acyloxy; a cyano; an --NR.sub.6 R.sub.7 group; an --NR.sub.3 COR.sub.4 group; an --NR.sub.3 COOR.sub.8 group; an --NR.sub.3 SO.sub.2 R.sub.9 group; an --NR.sub.3 CONR.sub.10 R.sub.12 group; a (C.sub.1 -C.sub.7)acyl group; a (C.sub.1 -C.sub.7)alkoxycarbonyl; a --CONR.sub.10 R.sub.12 group; a --CH.sub.2 OH group; a (C.sub.1 -C.sub.7)alkoxymethyl; a (C.sub.1 -C.sub.7)acyloxymethyl; a (C.sub.1 -C.sub.7)alkylaminocarbonyloxymethyl; a --CH.sub.2 NR.sub.13 R.sub.14 group; a --CH.sub.2 NR.sub.3 COR.sub.4 group; a --CH.sub.2 NR.sub.3 COOR.sub.8 group; a --CH.sub.2 NR.sub.3 SO.sub.2 R.sub.9 group; a --CH.sub.2 NR.sub.3 CONR.sub.10 R.sub.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: September 26, 2000
    Assignee: Sanofi
    Inventors: Daniel Bichon, Patrick Gueule, Didier Van Broeck, Xavier Emonds-Alt, Vincenzo Proietto
  • Human NK.sub.3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them
    Patent number: 6028082
    Abstract: Compounds of formula (I), a method for obtaining them and pharmaceutical compositions containing them are described. The compounds are useful as human NK.sub.3 receptor antagonists.
    Type: Grant
    Filed: March 12, 1998
    Date of Patent: February 22, 2000
    Assignee: Sanofi-Synthelabo
    Inventors: Daniel Bichon, Xavier Emonds-Alt, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck
  • Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present
    Patent number: 6011154
    Abstract: The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from:A.sub.1) --O--CO--A.sub.2) --CH.sub.2 --O--CO--A.sub.3) --O--CH.sub.2 --CO--A.sub.4) --O--CH.sub.2 --CH.sub.2 --A.sub.5) --N(R.sub.1)--CO--A.sub.6) --N(R.sub.1)--CO--CO--A.sub.7) --N(R.sub.1)--CH.sub.2 --CH.sub.2 --A.sub.8) --O--CH.sub.2 --in which:R.sub.1 is a hydrogen or a (C.sub.1 -C.sub.4)-alkyl; andAm is a nitrogen-containing heterocycle.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: January 4, 2000
    Assignee: Sanofi
    Inventors: Xavier Emonds-Alt, Isabelle Grossriether, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck, Joelle Taillades
  • Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present
    Patent number: 5977359
    Abstract: The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from:A.sub.1) --O--CO--A.sub.2) --CH.sub.2 --O--CO--A.sub.3) --O--CH.sub.2 --CO--A.sub.4) --O--CH.sub.2 --CH.sub.2 --A.sub.5) --N(R.sub.1)--CO--A.sub.6) --N(R.sub.1)--CO--CO--A.sub.7) --N(R.sub.1)--CH.sub.2 --CH.sub.2 --A.sub.8) --O--CH.sub.2 --in which:R.sub.1 is a hydrogen or a (C.sub.1 -C.sub.4)-alkyl; andAm is a nitrogen-containing heterocycle.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: November 2, 1999
    Assignee: Sanofi
    Inventors: Xavier Emonds-Alt, Isabelle Grossriether, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck
  • Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them
    Patent number: 5965580
    Abstract: Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them, of formula ##STR1## used as neurokinin receptor antagonists, which are, in particular, useful for the treatment of all substance P- and neurokinin-dependent pathologies.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: October 12, 1999
    Assignee: Sanofi
    Inventors: Nathalie Chabert, Jean-Philippe Ducoux, Xavier Emonds-Alt, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck
  • Compounds which are selective antagonists of the human NK.sub.3 receptor and their use as medicinal products and diagnostic tools
    Patent number: 5942523
    Abstract: A compound of formula: in which:Ar represents a pyrid-2-yl or a phenyl which is unsubstituted or substituted by a halogen, a methyl or a (C.sub.1 -C.sub.4)alkoxy;R.sub.1 represents a methyl group;R.sub.11 represents hydrogen;or R.sub.1 and R.sub.11 together represent a --(CH.sub.2).sub.3 -- group;R.sub.2 represents a hydroxyl; a (C.sub.1 -C.sub.7)alkoxy; a (C.sub.1 -C.sub.7)acyloxy; a cyano; an --NR.sub.6 R.sub.7 group; an --NR.sub.3 COR.sub.4 group; an --NR.sub.3 COOR.sub.8 group; an --NR.sub.3 SO.sub.2 R.sub.9 group; an --NR.sub.3 CONR.sub.10 R.sub.12 group; a (C.sub.1 -C.sub.7)acyl group; a (C.sub.1 -C.sub.7)alkoxycarbonyl; a --CONR.sub.10 R.sub.12 group; a --CH.sub.2 OH group; a (C.sub.1 -C.sub.7)alkoxymethyl; a (C.sub.1 -C.sub.7)acyloxymethyl; a (C.sub.1 -C.sub.7)alkylaminocarbonyloxymethyl; a --CH.sub.2 NR.sub.13 R.sub.14 group; a --CH.sub.2 NR.sub.3 COR.sub.4 group; a --CH.sub.2 NR.sub.3 COOR.sub.8 group; a --CH.sub.2 NR.sub.3 SO.sub.2 R.sub.9 group; a --CH.sub.2 NR.sub.3 CONR.sub.10 R.sub.
    Type: Grant
    Filed: February 29, 1996
    Date of Patent: August 24, 1999
    Assignee: Sanofi
    Inventors: Daniel Bichon, Patrick Gueule, Didier Van Broeck, Xavier Emonds-Alt, Vincenzo Proietto
  • Piperidine derivatives process for obtaining them and pharmaceutical compositions containing them
    Patent number: 5939411
    Abstract: Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them, of formula ##STR1## used as neurokinin receptor antagonists, which are, in particular, useful for the treatment of all substance P- and neurokinin-dependent pathologies.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: August 17, 1999
    Assignee: Sanofi
    Inventors: Nathalie Chabert, Jean-Philippe Ducoux, Xavier Emonds-Alt, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck
  • Dialkylenepiperidino compounds and their enantiomers, process for preparing them and pharmaceutical compositions containing them
    Patent number: 5877321
    Abstract: A compound of formula XXII ##STR1## wherein Ar', Q' and Q" are as defined in the specification are useful intermediates for making neurokinin receptor active compounds.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: March 2, 1999
    Assignee: Sanofi
    Inventors: Xavier Emonds-Alt, Isabelle Grossriether, Vincenzo Proietto, Didier Van Broeck
  • Substituted heterocyclic compounds
    Patent number: 5869663
    Abstract: The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from:A.sub.1) --O--CO--A.sub.2) --CH.sub.2 --O--CO--A.sub.3) --O--CH.sub.2 --CO--A.sub.4) --O--CH.sub.2 --CH.sub.2 --A.sub.5) --N(R.sub.1)--CO--A.sub.6) --N(R.sub.1)--CO--CO--A.sub.7) --N(R.sub.1)--CH.sub.2 --CH.sub.2 --A.sub.8) --O--CH.sub.2 --in which:R.sub.1 is a hydrogen or a (C.sub.1 -C.sub.4)-alkyl; andAm is a nitrogen-containing heterocycle.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: February 9, 1999
    Assignee: Sanofi
    Inventors: Xavier Emonds-Alt, Isabelle Grossriether, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck