Patents by Inventor Dietmar Flubacher

Dietmar Flubacher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compositions of lipoic acid choline ester salts and methods of treatment using same
    Patent number: 11590158
    Abstract: The present disclosure provides salts of lipoic acid choline ester (LACE), crystalline forms thereof, and methods of use thereof. The present disclosure further provides pharmaceutical compositions of LACE salts and methods of use thereof.
    Type: Grant
    Filed: August 31, 2021
    Date of Patent: February 28, 2023
    Assignee: Novartis AG
    Inventors: Christoph Bucher, Dietmar Flubacher, Jeremiah Douglas Foutch, Malay Ghosh, Johannes Franz Kluge, Zaixing Li, Cale Ry McAlister, Liladhar Murlidhar Waykole, Jens Sören Worthmann, Tingying Zhu
  • PHARMACEUTICAL COMPOSITIONS OF LIPOIC ACID CHOLINE ESTER SALTS AND METHODS OF TREATMENT USING SAME
    Publication number: 20210393671
    Abstract: The present disclosure provides salts of lipoic acid choline ester (LACE), crystalline forms thereof, and methods of use thereof. The present disclosure further provides pharmaceutical compositions of LACE salts and methods of use thereof.
    Type: Application
    Filed: August 31, 2021
    Publication date: December 23, 2021
    Inventors: Christoph Bucher, Dietmar Flubacher, Jeremiah Douglas Foutch, Malay Ghosh, Johannes Franz Kluge, Zaixing Li, Cale Ry McAlister, Liladhar Murlidhar Waykole, Jens Sören Worthmann, Tingying Zhu
  • Pharmaceutical compositions of lipoic acid choline ester salts and methods of treatment using same
    Patent number: 11135239
    Abstract: The present disclosure provides salts of lipoic acid choline ester (LACE), crystalline forms thereof, and methods of use thereof. The present disclosure further provides pharmaceutical compositions of LACE salts and methods of use thereof.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: October 5, 2021
    Assignee: NOVARTIS AG
    Inventors: Christoph Bucher, Dietmar Flubacher, Jeremiah Douglas Foutch, Malay Ghosh, Johannes Franz Kluge, Zaixing Li, Cale Ry McAlister, Liladhar Murlidhar Waykole, Jens Sören Worthmann, Tingying Zhu
  • PHARMACEUTICAL COMPOSITIONS OF LIPOIC ACID CHOLINE ESTER SALTS AND METHODS OF TREATMENT USING SAME
    Publication number: 20210283171
    Abstract: The present disclosure provides salts of lipoic acid choline ester (LACE), crystalline forms thereof, and methods of use thereof. The present disclosure further provides pharmaceutical compositions of LACE salts and methods of use thereof.
    Type: Application
    Filed: March 12, 2021
    Publication date: September 16, 2021
    Inventors: Christoph Bucher, Dietmar Flubacher, Jeremiah Douglas Foutch, Malay Ghosh, Johannes Franz Kluge, Zaixing Li, Cale Ry McAlister, Liladhar Murlidhar Waykole, Jens Sören Worthmann, Tingying Zhu
  • Chemical Process for Preparing Imidazopyrrolidinone Derivatives and Intermediates Thereof
    Publication number: 20210087194
    Abstract: The present disclosure relates to a method of synthesizing imidazopyrrolidinone derivative, such as compound of formula (I), or a solvate including hydrate thereof, or a co-crystal thereof, and/or intermediates thereof, their use as pharmaceuticals and the use of intermediates.
    Type: Application
    Filed: September 1, 2020
    Publication date: March 25, 2021
    Inventors: Hao Wang, Jiong Ye, Bo Han, Dietmar Flubacher, Hans Stettler, Fabrice Gallou, Franck Mallet, Matthias Napp, Michael Haller
  • Chemical Process for Preparing Imidazopyrrolidinone Derivatives and Intermediates Thereof
    Publication number: 20190337952
    Abstract: The present disclosure relates to a method of synthesizing imidazopyrrolidi-none derivative, such as compound of formula (I), or a solvate including hydrate thereof, or a co-crystal thereof, and/or intermediates thereof, their use as pharmaceuticals and the use of intermediates.
    Type: Application
    Filed: November 20, 2017
    Publication date: November 7, 2019
    Inventors: Hao Wang, Jiong Ye, Bo Han, Dietmar Flubacher, Hans Stettler, Fabrice Gallou, Franck Mallet, Matthias Napp, Michael Haller
  • Process for manufacturing 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine
    Patent number: 9637468
    Abstract: The invention discloses improved processes for manufacturing a compound, 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine, its monohydrochloride salt and intermediates thereof.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 2, 2017
    Assignee: Novartis AG
    Inventors: Dietmar Flubacher, Nicole Bieri, Murat Acemoglu, Pascal Michel, Rasmus Mose, Hans Stettler, Maria Caterina Testa, Joerg Brozio, Frank Schaefer
  • Manufacturing process for pyrimidine derivatives
    Patent number: 9452994
    Abstract: The invention relates to processes for manufacturing a compound of formula 5, or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of such solid forms for the therapeutic treatment of warm-blooded animals.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: September 27, 2016
    Assignee: Novartis AG
    Inventors: Dietmar Flubacher, Pascal Michel, Maria Caterina Testa, Rasmus Mose
  • MANUFACTURING PROCESS FOR PYRIMIDINE DERIVATIVES
    Publication number: 20160251334
    Abstract: The invention relates to processes for manufacturing a compound of formula 5, or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of such solid forms for the therapeutic treatment of warm-blooded animals.
    Type: Application
    Filed: May 6, 2016
    Publication date: September 1, 2016
    Inventors: Dietmar Flubacher, Pascal Michel, Maria Caterina Testa, Rasmus Mose
  • Process for Manufacturing 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine
    Publication number: 20150246897
    Abstract: The invention discloses improved processes for manufacturing a compound, 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine, its monohydrochloride salt and intermediates thereof.
    Type: Application
    Filed: October 21, 2013
    Publication date: September 3, 2015
    Inventors: Dietmar FLUBACHER, Nicole BIERI, Murat ACEMOGLU, Pascal MICHEL, Rasmus MOSE, Hans STETTLER, Caterina Maria TESTA, Jörg BROZIO, Frank SCHAEFER
  • MANUFACTURING PROCESS FOR PYRIMIDINE DERIVATIVES
    Publication number: 20150232446
    Abstract: The invention relates to processes for manufacturing a compound of formula 5, or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of such solid forms for the therapeutic treatment of warm-blooded animals.
    Type: Application
    Filed: May 6, 2015
    Publication date: August 20, 2015
    Inventors: John Vincent Calienni, Dietmar Flubacher, Baoqing Gong, Prasad Kapa, Hui Liu, Pascal Michel, Rasmus Mose, Maria Caterina Testa
  • MANUFACTURING PROCESS FOR PYRIMIDINE DERIVATIVES
    Publication number: 20130225571
    Abstract: The invention relates to new crystalline forms of processes for manufacturing a compound of formula 5, or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of said solid forms for the therapeutic treatment of warm-blooded animals.
    Type: Application
    Filed: September 29, 2011
    Publication date: August 29, 2013
    Applicant: NOVARTIS AG
    Inventors: John Vincent Calienni, Marilyn De La Cruz, Dietmar Flubacher, Baoqing Gong, Prasad Koteswara Kapa, Piotr H. Karpinski, Hui Liu, Pascal Michel, Rasmus Mose, Maria Caterina Testa, Liladhar Murlidhar Waykole
  • Process for preparing prophyrin derivatives, such as protoprophyrin (IX) and synthesis intermediates
    Patent number: 8420805
    Abstract: The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R? are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R?b is as defined above for (I), and a dipyrromethane of formula (III): in which R? is as defined in claim 1, and also the compounds of formula (III).
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: April 16, 2013
    Assignee: Sanofi Pasteur S.A.
    Inventors: Pierre Martin, Markus Mueller, Dirk Spielvogel, Dietmar Flubacher, Andreas Boudier
  • Process For Preparing Prophyrin Derivatives, Such As Protoprophyrin (IX) And Synthesis Intermediates
    Publication number: 20110306761
    Abstract: The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R? are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R?b is as defined above for (I), and a dipyrromethane of formula (III): in which R? is as defined in claim 1, and also the compounds of formula (III).
    Type: Application
    Filed: August 25, 2011
    Publication date: December 15, 2011
    Applicant: SANOFI PASTEUR SA
    Inventors: Pierre Martin, Markus Mueller, Dirk Spielvogel, Dietmar Flubacher, Andreas Boudier
  • Process for preparing porphyrin derivatives, such as protoporphyrin (IX) and synthesis intermediates
    Patent number: 8026358
    Abstract: The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R? are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R?b is as defined above for (I), and a dipyrromethane of formula (III): in which R? is as defined in claim 1, and also the compounds of formula (III).
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: September 27, 2011
    Assignee: Sanofi Pasteur S.A.
    Inventors: Pierre Martin, Markus Mueller, Dirk Spielvogel, Dietmar Flubacher, Andreas Boudier
  • NOVEL AMINODICARBOXYLIC ACID DERIVATIVES HAVING PHARMACEUTICAL PROPERTIES
    Publication number: 20100317854
    Abstract: The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.
    Type: Application
    Filed: August 23, 2010
    Publication date: December 16, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Cristina Alonso-Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Josef Pernerstorfer, Johannes-Peter Stasch, Frank Wunder, Klaus Dembowsky, Elizabeth Perzborn, Elke Stahl
  • Aminodicarboxylic acid derivatives having pharmaceutical properties
    Patent number: 7781470
    Abstract: The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: August 24, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Cristina Alonso-Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Josef Pernerstorfer, Johannes-Peter Stasch, Frank Wunder, Klaus Dembowsky, Elizabeth Perzborn, Elke Stahl
  • Dicarboxylic acid derivatives with pharmaceutical properties
    Patent number: 7674825
    Abstract: The present invention relates to the use of compounds of the formula (I) and to their salts and stereoisomers, for the preparation of medicaments for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: March 9, 2010
    Assignee: Bayer Aktiengesellschaft
    Inventors: Cristina Alonso-Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Johannes-Peter Stasch, Frank Wunder, Klaus Dembowsky, Elisabeth Perzborn, Elke Stahl
  • NOVEL AMINODICARBOXYLIC ACID DERIVATIVES HAVING PHARMACEUTICAL PROPERTIES
    Publication number: 20090203906
    Abstract: The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.
    Type: Application
    Filed: April 13, 2009
    Publication date: August 13, 2009
    Applicant: Bayer Aktiengesellschaft
    Inventors: Cristina Alonso-Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Josef Pernerstorfer, Johannes-Peter Stasch, Frank Wunder, Klaus Dembowsky, Elizabeth Perzborn, Elke Stahl
  • Process for the preparation of crystalline forms A, B and pure crystalline form a of erlotinib HCI
    Publication number: 20090131665
    Abstract: The invention provides processes for preparing crystalline Forms A, B and pure crystalline Form A of Erlotinib hydrochloride.
    Type: Application
    Filed: August 25, 2008
    Publication date: May 21, 2009
    Inventors: Ales Gavenda, Jiri Faustmann, Augusto Canavesi, Dietmar Flubacher