Abstract: The invention relates to a patch (2) with at least one filler and at least one active ingredient, wherein the local distribution of the active ingredient or ingredients within the patch (2) takes place dependent on the morphology, anatomy and physiology of the lesion (1) to be treated.

Abstract: The invention relates to a patch (2) with at least one filler and at least one active ingredient, wherein the local distribution of the active ingredient or ingredients within the patch (2) takes place dependent on the morphology, anatomy and physiology of the lesion (1) to be treated.

Abstract: The invention relates to a material for the 3-dimensional printing of scaffold structures on a 3D printer as well as to a medical implant (1) made of this type of material and the use of this type of material for manufacturing a medical implant (1) of this type. According to the invention, the material has integrated microspheres (5) which emit radioactive rays.

Abstract: Systems and method to affect anatomical structures is disclosed. The systems and method can be used to regenerate bone. The system can comprise a nanofiber mesh configured to substantially conform to an anatomical structure, wherein at least a portion of the nanofiber mesh defines a fillable space. The system can comprise a carrier substance comprising an active agent, such as a bone morphogenetic protein, The carrier substance can be disposed within the fillable space.

Abstract: Osoteogenic implants, and related compositions, methods and kits. The implants comprise a biodegradable scaffold comprising a polycaprolactone matrix and tricalcium phosphate particles within the matrix. The implants further include a formulation comprising BMP-7.

Abstract: The various embodiments of the present invention are generally directed to systems and methods to affect anatomical structures. More particularly, the various embodiments of the present invention are directed to systems and methods to regenerate bone. An aspect of the present invention comprises a system for affecting an anatomical structure, comprising: a nanofiber mesh configured to substantially conform to an anatomical structure, wherein at least a portion of the nanofiber mesh defines a fillable space; a carrier substance comprising an active agent, such as a bone morphogenetic protein, wherein the carrier substance is disposed within the fillable space.

Abstract: The invention relates to a bioreactor comprising a chamber for containing cells or tissue cultures within a culture medium. The bioreactor also comprises a detector capable of detecting a change in one or more metabolites associated with growth of the cell or tissue cultures within the chamber and a chamber drive capable of rotating the chamber at a first speed about a first axis and a second speed about a second axis, the second axis being disposed at an angle relative to the first axis. In use, the magnitude of the first speed and the second speed are independently variable of each other.

Abstract: The invention relates to a continuous flow dual axis bioreactor (10) for growing three-dimensional cell or tissue cultures. The bioreactor (10) includes a chamber (12) adapted to contain a three-dimensional matrix for growing three-dimensional cell or tissue cultures. A rotatable plate (14) supports the chamber (12) and is rotatable about a vertical axis (16). The rotatable plate (14) is supported on an rotary L-shaped bracket (20) that rotates about a horizontal axis (22). Two multi-flow fluid connectors (32,34) are provided to prevent any pipes connecting the chamber to a feed source or a product tank from being entangled and to allow continuous flow to and from the bioreactor (10).