Patents by Inventor Dilip Wagle

Dilip Wagle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating diabetic nephropathy
    Publication number: 20090124673
    Abstract: Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:
    Type: Application
    Filed: January 9, 2009
    Publication date: May 14, 2009
    Applicant: Synvista Therapeutics , Inc.
    Inventors: John Egan, Sara Vasan, Martin Gall, Sheng Ding Fang, Dilip Wagle, Pramod Wagle
  • Method for treating congestive heart failure
    Publication number: 20090124674
    Abstract: Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:
    Type: Application
    Filed: January 9, 2009
    Publication date: May 14, 2009
    Applicant: Synvista Therapeutics, Inc.
    Inventors: John Egan, Sara Vasan, Martin Gall, Sheng Ding Fang, Dilip Wagle, Parmod Wagle
  • Method for treating glaucoma IC
    Patent number: 7432254
    Abstract: Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising administering an intraocular pressure decreasing or accommodation improving amount of a compound of the formula I:
    Type: Grant
    Filed: December 31, 2001
    Date of Patent: October 7, 2008
    Assignee: Synvista Therapeutics, Inc.
    Inventors: John J. Egan, Dilip Wagle, Sara Vasan, Martin Gall, Stanley Bell, Edmond Joseph LaVoie
  • Method for treating glaucoma IIB
    Publication number: 20070161616
    Abstract: Provided is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure decreasing amount or ocular accommodation improving amount of a compound of the formula I or IA, wherein J is oxygen, sulfur, or N—Rd.
    Type: Application
    Filed: July 6, 2006
    Publication date: July 12, 2007
    Inventors: Dilip Wagle, Martin Gall, Stanley Bell, Edmond LaVoie
  • Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disorders associated with protein aging
    Publication number: 20070099892
    Abstract: Provided, among other things, is a compound of the formula:
    Type: Application
    Filed: May 10, 2006
    Publication date: May 3, 2007
    Inventors: Dilip Wagle, Sheng Fang
  • Method of treating fibrotic diseases or other indications with imidazolium agents
    Publication number: 20070043016
    Abstract: Provided is a method of treating or ameliorating an indication of the invention in an animal, including a human, by administering an effective amount of a compound of the formula I: wherein R1, R2, M, X and Z are as described supra. Also provided are certain imidazolium compounds and pharmaceutical compositions containing the imidazolium compounds.
    Type: Application
    Filed: February 9, 2006
    Publication date: February 22, 2007
    Inventors: Dilip Wagle, Sara Vasan, Martin Gall
  • Preventing and reversing the formation of advance glycosylation endproducts
    Publication number: 20070025926
    Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain useful agents are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.
    Type: Application
    Filed: February 9, 2006
    Publication date: February 1, 2007
    Inventors: Anthony Cerami, Peter Ulrich, Dilip Wagle, San-Bao Hwang, Sara Vasan, John Egan
  • Method for treating fibrotic diseases and other indications
    Patent number: 7166625
    Abstract: Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:
    Type: Grant
    Filed: December 31, 2001
    Date of Patent: January 23, 2007
    Assignee: Alteon, Inc.
    Inventors: John J. Egan, Dilip Wagle, Sara Vasan, Martin Gall, Stanley Bell, Edmond J. LaVoie
  • Method for treating glaucoma III B
    Publication number: 20060287318
    Abstract: Provided, among other things, is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure decreasing or ocular accommodation improving amount of a compound of the formula (1): Y-Ar?•X?
    Type: Application
    Filed: December 5, 2005
    Publication date: December 21, 2006
    Inventors: Dilip Wagle, Martin Gall, Stanley Bell, Edmond LaVoie
  • Method for treating glaucoma IV B
    Publication number: 20060281749
    Abstract: Provided, among other things, is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure decreasing or ocular accommodation improving amount of a compound of the formula (I): Het-Y.
    Type: Application
    Filed: December 6, 2005
    Publication date: December 14, 2006
    Inventors: Dilip Wagle, Martin Gall, Stanley Bell, Edmond LaVoie
  • Method for treating fibrotic diseases or other indications utilizing thiazole, oxazole and imidazole compounds
    Patent number: 7026342
    Abstract: Provided is a method of treating or ameliorating a number of indications in an animal, including a human, comprising administering an effective amount of a compound of the formula I or IA, wherein J is oxygen, sulfur, or N—Rd.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: April 11, 2006
    Assignee: Alteon, Inc.
    Inventors: Dilip Wagle, Martin Gall, Stanley C. Bell, Edmond J. LaVoie
  • Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging
    Publication number: 20060014781
    Abstract: Provided are, among other things, compounds of formula I or IA,
    Type: Application
    Filed: August 15, 2005
    Publication date: January 19, 2006
    Inventors: Dilip Wagle, Sara Vasan, John Egan
  • Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging
    Patent number: 6960605
    Abstract: Provided are, among other things, compounds of formula I or IA, Also provided are methods of treatment with such compounds.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: November 1, 2005
    Assignee: Alteon, Inc.
    Inventors: Dilip Wagle, Sarah Vasan, Jack Egan
  • Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disorders associated with protein aging
    Publication number: 20050032865
    Abstract: Provided, among other things, is a compound of the formula:
    Type: Application
    Filed: August 21, 2003
    Publication date: February 10, 2005
    Inventors: Dilip Wagle, Sheng Fang
  • Method for treating fibrotic diseases or other indications utilizing thiazole, oxazole and imidazole compounds
    Publication number: 20050032788
    Abstract: Provided is a method of treating or ameliorating a number of indications in an animal, including a human, comprising administering an effective amount of a compound of the formula I or IA, wherein J is oxygen, sulfur, or N—Rd.
    Type: Application
    Filed: May 24, 2004
    Publication date: February 10, 2005
    Inventors: Dilip Wagle, Martin Gall, Stanley Bell, Edmond LaVoie
  • Method for treating fibrotic diseases or other indications IE
    Publication number: 20040235837
    Abstract: Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: 1
    Type: Application
    Filed: June 21, 2004
    Publication date: November 25, 2004
    Inventors: John Egan, Sara Vasan, Martin Gall, Sheng Ding Fang, Pramod Wagle, Dilip Wagle
  • Method for treating fibrotic diseases or other indications utilizing thiazole, oxazole and imidazole compounds
    Patent number: 6770663
    Abstract: Provided is a method of treating or ameliorating a number of indications in an animal, including a human, comprising administering an effective amount of a compound of the formula I or IA, wherein J is oxygen, sulfur, or N—Rd.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: August 3, 2004
    Assignee: Alteon, Inc.
    Inventors: Dilip Wagle, Martin Gall, Stanley C. Bell, Edmond J. LaVoie
  • Method for treating fibrotic diseases or other indications IIIC
    Publication number: 20040097495
    Abstract: Provided is a method of treating or ameliorating certain fibrotic diseases or other indications in an animal, including a human, comprising administering an effective amount of a compound of the formula I:
    Type: Application
    Filed: October 23, 2003
    Publication date: May 20, 2004
    Inventors: Dilip Wagle, Martin Gall, Stanley C. Bell, Edmond J. LaVoie
  • Method for treating fibrotic diseases or other indications utilizing thiazole, oxazole and imidazole compounds
    Publication number: 20030225146
    Abstract: Provided is a method of treating or ameliorating a number of indications in an animal, including a human, comprising administering an effective amount of a compound of the formula I or IA, 1
    Type: Application
    Filed: May 19, 2003
    Publication date: December 4, 2003
    Inventors: Dilip Wagle, Martin Gall, Stanley C. Bell, Edmond J. LaVoie
  • Method for treating fibrotic diseases or other indications with imidazolium agents
    Publication number: 20030176426
    Abstract: Provided is a method of treating or ameliorating an indication of the invention in an animal, including a human, by administering an effective amount of a compound of the formula I: 1
    Type: Application
    Filed: January 30, 2003
    Publication date: September 18, 2003
    Applicant: Alteon, Inc.
    Inventors: Dilip Wagle, Sara Vasan, Martin Gall