Patents by Inventor Dimitrios Stefanidis

Dimitrios Stefanidis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing concentrated aqueous micellar solutions
    Publication number: 20090218708
    Abstract: The present invention provides a method for preparing supersaturated aqueous solutions of micelles of compounds in which the solubility in water is less than the critical micelle concentration. The solutions can be process to prepare solid micelles which have advantageous properties for drug delivery.
    Type: Application
    Filed: February 20, 2009
    Publication date: September 3, 2009
    Inventors: Lawrence Emerson Fisher, Shridhar Hegde, Jane Kuo, Dimitrios Stefanidis, Fujun Li
  • Pharmaceutical composition and process
    Publication number: 20080260826
    Abstract: The present invention relates to a method of forming granules of (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate; hydrochloride salt (I), comprising mixing I, with a granulating amount of a granulating liquid, and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer as a binder and solubility enhancer to form wet granules which are then dried to remove the granulating liquid.
    Type: Application
    Filed: March 28, 2008
    Publication date: October 23, 2008
    Inventors: Kondamraj Birudaraj, Michael Thomas Brandl, Shridhar Hegde, Felix Sana, Dimitrios Stefanidis
  • Non-nucleoside reverse transcriptase inhibitors
    Patent number: 7288542
    Abstract: The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficieny virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human immunodeficieny virus containing a compound according to formula I where R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: October 30, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Todd Richard Elworthy, Joan Heather Hogg, Dimitrios Stefanidis
  • Pharmaceutical composition and process
    Publication number: 20070202175
    Abstract: The present invention relates to a pharmaceutical composition comprising a solid suspension prepared by hot melt extrusion of isobutyric acid (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl ester; hydrochloride salt (I) and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer.
    Type: Application
    Filed: December 13, 2006
    Publication date: August 30, 2007
    Inventors: Hashim Ahmed, Thomas Alfredson, Kondamraj Birudaraj, Michael Brandl, Wantanee Phuapradit, Navnit Shah, Dimitrios Stefanidis
  • Heterocyclic antiviral compounds
    Publication number: 20060025462
    Abstract: The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficieny virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human immunodeficieny virus containing a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.
    Type: Application
    Filed: July 27, 2005
    Publication date: February 2, 2006
    Inventors: James Dunn, Todd Elworthy, Dimitrios Stefanidis, Zachary Sweeney
  • Non-nucleoside reverse transcriptase inhibitors
    Publication number: 20050215554
    Abstract: The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficieny virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human immunodeficieny virus containing a compound according to formula I where R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
    Type: Application
    Filed: March 22, 2005
    Publication date: September 29, 2005
    Inventors: James Dunn, Todd Elworthy, Joan Hogg, Dimitrios Stefanidis