Patents by Inventor Dina Blasberger

Dina Blasberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of valacyclovir hydrochloride
    Publication number: 20050187229
    Abstract: Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.
    Type: Application
    Filed: January 25, 2005
    Publication date: August 25, 2005
    Inventors: Shlomit Wizel, Judith Aronhime, Valerie Niddam-Hildesheim, Ben-Zion Dolitzky, Marina Etinger, Michael Yuzefovich, Gennady Nisnevich, Boris Pertsikov, Boris Tishin, Dina Blasberger
  • Synthesis and purification of valacyclovir
    Publication number: 20050130993
    Abstract: The present invention relates to protected valacyclovir, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy] ethyl ester, and a method of making it. The present invention further relates to a method of making valacyclovir including the steps of coupling an amine protected valine selected from N-t-butoxycarbonyl valine and N-formyl valine with acyclovir using a coupling agent to form a protected valacyclovir, and deprotecting the protected valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The present invention further relates to valacyclovir in pure form, a method of making pure valacyclovir, and to compositions containing pure valacyclovir.
    Type: Application
    Filed: January 25, 2005
    Publication date: June 16, 2005
    Inventors: Marina Etinger, Lev Yudovich, Michael Yuzefovich, Gennady Nisnevich, Ben Dolitzky, Boris Pertsikov, Boris Tishin, Dina Blasberger
  • Crystalline forms of valacyclovir hydrochloride
    Publication number: 20050043329
    Abstract: Provided are novel crystalline forms of valacyclovir hydrochloride, in particular a novel hydrated form of valacyclovir hydrochloride having about 6% to about 10% by weight water. Also provided are methods for making the novel crystalline forms.
    Type: Application
    Filed: March 1, 2004
    Publication date: February 24, 2005
    Inventors: Shlomit Wizel, Judith Aronhime, Valerie Niddam-Hildesheim, Ben-Zion Dolitzky, Marina Etinger, Michael Yuzefovich, Gennady Nisnevich, Boris Pertsikov, Boris Tishin, Dina Blasberger
  • Synthesis and purification of valacyclovir
    Patent number: 6849737
    Abstract: The present invention relates to protected valacyclovir, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy] ethyl ester, and a method of making it. The present invention further relates to a method of making valacyclovir including the steps of coupling an amine protected valine selected from N-t-butoxycarbonyl valine and N-formyl valine with acyclovir using a coupling agent to form a protected valacyclovir, and deprotecting the protected valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The present invention further relates to valacyclovir in pure form, a method of making pure valacyclovir, and to compositions containing pure valacyclovir.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: February 1, 2005
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Marina Yu Etinger, Lev M. Yudovich, Michael Yuzefovich, Gennady A. Nisnevich, Ben Zion Dolitzky, Boris Pertsikov, Boris Tishin, Dina Blasberger
  • Crystalline forms of valacyclovir hydrochloride
    Patent number: 6849736
    Abstract: Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: February 1, 2005
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Shlomit Wizel, Judith Aronhime, Valerie Niddam-Hildesheim, Ben-Zion Dolitzky, Marina Yu Etinger, Michael Yuzefovich, Gennady A. Nisnevich, Boris Pertsikov, Boris Tishin, Dina Blasberger
  • Synthesis and purification of valacyclovir
    Publication number: 20030153757
    Abstract: The present invention relates to protected valacyclovir, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy] ethyl ester, and a method of making it. The present invention further relates to a method of making valacyclovir including the steps of coupling an amine protected valine selected from N-t-butoxycarbonyl valine and N-formyl valine with acyclovir using a coupling agent to form a protected valacyclovir, and deprotecting the protected valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The present invention further relates to valacyclovir in pure form, a method of making pure valacyclovir, and to compositions containing pure valacyclovir.
    Type: Application
    Filed: November 13, 2002
    Publication date: August 14, 2003
    Inventors: Marina Yu Etinger, Lev M. Yudovich, Michael Yuzefovich, Gennady A. Nisnevich, Ben Zion Dolitzky, Boris Pertsikov, Boris Tishin, Dina Blasberger
  • Crystalline forms of valacyclovir hydrochloride
    Publication number: 20030114470
    Abstract: Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.
    Type: Application
    Filed: September 6, 2002
    Publication date: June 19, 2003
    Inventors: Shlomit Wizel, Judith Aronhime, Valerie Niddam-Hildesheim, Ben-Zion Dolitzky, Marina Yu Etinger, Michael Yuzefovich, Gennady A. Nisnevich, Boris Pertsikov, Boris Tishin, Dina Blasberger
  • New compounds for the study and treatment of microfilament organization in cells
    Patent number: 4857538
    Abstract: A compound, and composition including same, for effecting irreversible change in cell morphology having the following structures: ##STR1## wherein R is --(CH.sub.2).sub.n ZH in which n=1, 2, 3 and 4 and Z is O, S, or NH, and ##STR2## wherein R.sub.1 and R.sub.2 can be --OH, alkyl and acyl.
    Type: Grant
    Filed: November 30, 1987
    Date of Patent: August 15, 1989
    Assignee: The Research Foundation of State University of New York
    Inventors: Yoel Kashman, Ilan Spector, Shmuel Carmely, Dina Blasberger