Patents by Inventor Dinesh Gala

Dinesh Gala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF OLIGONUCLEOTIDES AND RELATED COMPOUNDS
    Publication number: 20240092821
    Abstract: Methods of synthesizing oligonucleotides via new intermediates on a cleavable support having an azidomethyl moiety are disclosed. The method comprises multiple reaction cycles, each of which comprises sequential coupling a nucleoside or oligonucleotide subunit on a cleavable support having an azidomethyl moiety and a nucleoside phosphoramidite or an oligonucleotide phosphoramidite, capping, oxidation/thiolation and deblocking; followed by orthogonal cleavage of the azidomethyl support while keeping all other protecting groups intact. The method can be used in combination with a support moiety for either solid phase or liquid phase oligo synthesis. The soluble support facilitates homogeneous reactions and efficient separations by simple precipitation. The methods also provide novel intermediates useful in the synthesis of oligonucleotide conjugates.
    Type: Application
    Filed: March 30, 2021
    Publication date: March 21, 2024
    Inventors: Minghong Zhong, Yi Jin, Dinesh Gala, Marija Prhavc
  • Process for Preparing Imetelstat
    Publication number: 20230070069
    Abstract: The present invention relates to a process for preparing the telomerase inhibitor imetelstat using a 3 steps per cycle solid-phase support bound process comprising the steps of deprotection of the 3?-amino group of the support-bound oligonucleotide, coupling with a 5?-phosphoramidite, and sulfurization with an acyl disulfide, characterized by the absence of an additional capping step in each cycle that is used to prevent unreacted 3?-amino oligonucleotide groups from reacting during subsequent cycles. Imetelstat has formula below.
    Type: Application
    Filed: April 12, 2022
    Publication date: March 9, 2023
    Inventors: Jale MUSLEHIDDINOGLU, Dinesh GALA, Jennifer Elizabeth ALBANEZE-WALKER
  • Process for preparing imetelstat
    Patent number: 11332489
    Abstract: The present invention relates to a process for preparing the telomerase inhibitor imetelstat using a 3 steps per cycle phase support bound process comprising the steps of deprotection of the 3?-amino group of the support-bound oligonucleotide, coupling with a 5?-phosphoramidite, and sulfurization with an acyl disulfide, characterized by the absence of an additional capping step in each cycle that is used to prevent unreacted 3?-amino oligonucleotide groups from reacting during subsequent cycles. Imetelstat has formula below.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: May 17, 2022
    Assignee: Geron Corporation
    Inventors: Jale Muslehiddinoglu, Dinesh Gala, Jennifer Elizabeth Albaneze-Walker
  • IMPROVED SYNTHETIC METHODS OF MAKING FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS
    Publication number: 20220009932
    Abstract: Processes for preparing (((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl) methanone are described, which are useful for commercial manufacturing. Said compound is an orexin receptor modulator and may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia and depression.
    Type: Application
    Filed: November 11, 2019
    Publication date: January 13, 2022
    Inventors: Dominique Paul Michel DEPRÉ, Kiran MATCHA, Andy Josephina Joannes HUYGAERTS, Luc Jozef Raphael MOENS, Dinesh GALA
  • Improved Process for Preparing Imetelstat
    Publication number: 20200369702
    Abstract: The present invention relates to a process for preparing the telomerase inhibitor imetelstat using a 3 steps per cycle phase support bound process comprising the steps of deprotection of the 3?-amino group of the support-bound oligonucleotide, coupling with a 5?-phosphoramidite, and sulfurization with an acyl disulfide, characterized by the absence of an additional capping step in each cycle that is used to prevent unreacted 3?-amino oligonucleotide groups from reacting during subsequent cycles. Imetelstat has formula below.
    Type: Application
    Filed: July 9, 2018
    Publication date: November 26, 2020
    Inventors: Jale MUSLEHIDDINOGLU, Dinesh GALA, Jennifer Elizabeth ALBANEZE-WALKER
  • Stereoselective Alkylation of Chiral 2-Methly-4 Protected Piperazines
    Publication number: 20100249411
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Inventors: Wenxue Wu, Hongbiao Liao, David J.S. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Stereoselective alkylation of chiral 2-methyl-4-protected piperazines
    Patent number: 7745626
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: June 29, 2010
    Assignee: Schering Corporation
    Inventors: Wenxue Wu, Hongbiao Liao, David J. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Preparation of pharmaceutical salts
    Patent number: 7534884
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: May 19, 2009
    Assignee: Schering Corporation
    Inventors: Dinesh Gala, Andrew J. Goodman, Gary Lee, Hongbiao Liao, Martin L. Schwartz, Suhan Tang, David J. S. Tsai, Wenxue Wu
  • Synthesis of piperidine and piperazine compounds as CCR5 antagonists
    Patent number: 6992189
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: January 31, 2006
    Assignee: Schering Corporation
    Inventors: William Leong, Minzhang Chen, Bosco A. D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew J. Goodman, Christopher M. Nielsen, Gary M. Lee, Juan A. Gamboa, Andrew D. Jones
  • Preparation of salts of 4-[4-[(1R)-[4-(trifluoromethyl)phenyl]-2-methoxyethyl]-(3S)-methyl-1-piperazinyl]-4-methyl-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]
    Patent number: 6943251
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: September 13, 2005
    Assignee: Schering Corporation
    Inventors: Dinesh Gala, Andrew J. Goodman, Gary Lee, Hongbiao Liao, Martin L. Schwartz, Suhan Tang, David Js Tsai, Wenxue Wu
  • Synthesis of piperidine and piperazine compounds as CCR5 antagonists
    Publication number: 20050187248
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:
    Type: Application
    Filed: March 24, 2005
    Publication date: August 25, 2005
    Inventors: William Leong, Minzhang Chen, Bosco D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew Goodman, Christopher Nielsen, Gary Lee, Juan Gamboa, Andrew Jones
  • Stereoselective alkylation of chiral 2-methyl-4-protected piperazines
    Publication number: 20050171120
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Application
    Filed: March 25, 2005
    Publication date: August 4, 2005
    Inventors: Wenxue Wu, Hongbiao Liao, David Tsai, David Andrews, Dinesh Gala, Gary Lee, Martin Schwartz, Timothy McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram Thiruvengadam, Chou-Hang Tann
  • Preparation of pharmaceutical salts
    Publication number: 20050171117
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
    Type: Application
    Filed: March 30, 2005
    Publication date: August 4, 2005
    Inventors: Dinesh Gala, Andrew Goodman, Gary Lee, Hongbiao Liao, Martin Schwartz, Suhan Tang, David Tsai, Wenxue Wu
  • Process for synthesis of D1 receptor antagonists
    Patent number: 6875866
    Abstract: In one embodiment, the present invention describes the synthesis of a compound of formula and intermediates therefor.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: April 5, 2005
    Assignee: Schering Corporation
    Inventors: Vilas H. Dahanukar, Jeffrey M. Eckert, Dinesh Gala, Brian Lucas, Doris P. Schumacher, Ilia Zavialov
  • Stereoselective alkylation of chiral 2-methyl-4-protected piperazines
    Patent number: 6872826
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: March 29, 2005
    Assignee: Schering Corporation
    Inventors: Wenxue Wu, Hongbiao Liao, David J. S. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Synthesis of piperidine and piperazine compounds as CCR5 antagonists
    Publication number: 20040024217
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV: 1
    Type: Application
    Filed: March 27, 2003
    Publication date: February 5, 2004
    Applicant: Schering Corporation
    Inventors: William Leong, Minzhang Chen, Bosco A. D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew J. Goodman, Christopher M. Nielsen, Gary M. Lee, Juan A. Gamboa, Andrew D. Jones
  • Stereoselective alkylation of chiral 2-methyl-4-protected piperazines
    Publication number: 20030208074
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process: 1
    Type: Application
    Filed: March 27, 2003
    Publication date: November 6, 2003
    Applicant: Schering Corporation
    Inventors: Wenxue Wu, Hongbiao Liao, David J. S. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Process for synthesis of D1 receptor antagonists
    Publication number: 20030199690
    Abstract: In one embodiment, the present invention describes the synthesis of a compound of formula 1
    Type: Application
    Filed: February 19, 2003
    Publication date: October 23, 2003
    Applicant: Schering Corporation
    Inventors: Vilas H. Dahanukar, Jeffrey M. Eckert, Dinesh Gala, Brian Lucas, Doris P. Schumacher, Ilia Zavialov
  • Preparation of pharmaceutical salts
    Publication number: 20030144510
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
    Type: Application
    Filed: November 26, 2002
    Publication date: July 31, 2003
    Applicant: Schering Corporation
    Inventors: Dinesh Gala, Andrew J. Goodman, Gary Lee, Hongbiao Liao, Martin L. Schwartz, Suhan Tang, David Js Tsai, Wenxue Wu
  • Ethyl 4-(8-chloro-5,6-dihydro-11 H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidene carboxylate polymorph
    Patent number: 6335347
    Abstract: A polymorph form 2 of ethyl 4(8-chloro-5,6,-dihydro-11H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidene carboxylate (hereinafter “loratadine”) represented by the formula Pharmaceutical composition containing the polymorph form 2, and methods of using the polymorph form 2 to treat allergic reactions in mammals such as man are disclosed.
    Type: Grant
    Filed: October 8, 1998
    Date of Patent: January 1, 2002
    Assignee: Schering Corporation
    Inventors: Dinesh Gala, Donald J. DiBenedetto