Patents by Inventor Dino Dina

Dino Dina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric immunomodulatory compounds and methods of using the same—I
    Patent number: 7255868
    Abstract: The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: August 14, 2007
    Assignee: Dynavax Technologies Corporation
    Inventors: Karen L. Fearon, Dino Dina, Stephen F. Tuck
  • Biodegradable immunomodulatory formulations and methods for use thereof
    Patent number: 7250403
    Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or noncarrier.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: July 31, 2007
    Assignee: Dynavax Technologies Corporation
    Inventors: Gary Van Nest, Stephen Tuck, Karen L. Fearon, Dino Dina
  • Human immunodeficiency virus (HIV) nucleotide sequences, recombinant polypeptides, and applications thereof
    Patent number: 7205101
    Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: April 17, 2007
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Paul A. Luciw, Dino Dina
  • Chimeric immunomodulatory compounds and methods of using the same - IV
    Publication number: 20070049550
    Abstract: The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
    Type: Application
    Filed: October 30, 2006
    Publication date: March 1, 2007
    Applicant: Dynavax Technologies Corporation
    Inventors: Karen Fearon, Dino Dina, Stephen Tuck
  • Immunomodulatory formulations and methods for use thereof
    Patent number: 7183111
    Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a nonbiodegradable microcarrier or nanocarrier.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: February 27, 2007
    Assignee: Dynavax Technologies Corporation
    Inventors: Gary Van Nest, Stephen Tuck, Karen L. Fearon, Dino Dina
  • Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
    Publication number: 20070027098
    Abstract: The invention relates to immunostimulatory oligonucleotide compositions. These oligonucleotides comprise an immunostimulatory octanucleotide sequence. These oligonucleotides can be administered in conjunction with an immunostimulatory peptide or antigen. Methods for modulating an immune response upon administration of the oligonucleotide are also disclosed. In addition, an in vitro screening method to identify oligonucleotides with immunostimulatory activity is provided.
    Type: Application
    Filed: February 22, 2006
    Publication date: February 1, 2007
    Inventors: Eyal Raz, Mark Roman, Dino Dina
  • Immunostimulatory sequence oligonucleotides and methods of using the same
    Publication number: 20060058254
    Abstract: The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.
    Type: Application
    Filed: December 18, 2003
    Publication date: March 16, 2006
    Inventors: Dino Dina, Karen Fearon, Jason Marshall
  • Methods of treating IgE-associated disorders and compositions for use therein
    Publication number: 20060013811
    Abstract: The present invention provides methods of treating IgE-associated disorders and compositions for use therein. The methods are particularly useful in treatment of allergies and allergy-related disorders. The methods generally comprise administering an IgE inhibitor (such as anti-IgE antibody) and an antigen and/or immunostimulatory polynucleotide sequence (ISS). These combination methods offer significant advantages, such as allowing more aggressive therapy while reducing unwanted side effects, such as anaphylaxis.
    Type: Application
    Filed: May 17, 2005
    Publication date: January 19, 2006
    Inventor: Dino Dina
  • Chimeric immunomodulatory compounds and methods of using the same-IV
    Publication number: 20040132677
    Abstract: The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
    Type: Application
    Filed: July 18, 2003
    Publication date: July 8, 2004
    Inventors: Karen L. Fearon, Dino Dina, Stephen F. Tuck
  • Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
    Publication number: 20040006034
    Abstract: The invention relates to immunostimulatory oligonucleotide compositions. These oligonucleotides comprise an immunostimulatory octanucleotide sequence. These oligonucleotides can be administered in conjunction with an immunostimulatory peptide or antigen. Methods for modulating an immune response upon administration of the oligonucleotide are also disclosed. In addition, an in vitro screening method to identify oligonucleotides with immunostimulatory activity is provided.
    Type: Application
    Filed: April 11, 2003
    Publication date: January 8, 2004
    Inventors: Eyal Raz, David Schwartz, Mark Roman, Dino Dina
  • Chimeric immunomodulatory compounds and methods of using the same - III
    Publication number: 20030225016
    Abstract: The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
    Type: Application
    Filed: December 23, 2002
    Publication date: December 4, 2003
    Inventors: Karen L. Fearon, Dino Dina, Stephen F. Tuck
  • Chimeric immunomodulatory compounds and methods of using the same - ll
    Publication number: 20030199466
    Abstract: The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
    Type: Application
    Filed: June 21, 2002
    Publication date: October 23, 2003
    Inventors: Karen L. Fearon, Dino Dina, Stephen F. Tuck
  • Chimeric immunomodulatory compounds and methods of using the same - I
    Publication number: 20030175731
    Abstract: The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
    Type: Application
    Filed: June 21, 2002
    Publication date: September 18, 2003
    Inventors: Karen L. Fearon, Dino Dina, Stephen F. Tuck
  • Immunomodulatory compositions, formulations, and methods for use thereof
    Publication number: 20030133988
    Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMO/MC) complexes comprising 3-6 mer immunomodulatory oligonucleotides. The IMO/MC complexes may be covalently or non-covalently bound. Also provided are immunomodulatory compositions comprising a 3-6 mer IMO encapsulated in an MC.
    Type: Application
    Filed: August 7, 2002
    Publication date: July 17, 2003
    Inventors: Karen L. Fearon, Dino Dina
  • Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
    Patent number: 6589940
    Abstract: The invention relates to immunostimulatory oligonucleotide compositions. These oligonucleotides comprise an immunostimulatory octanucleotide sequence. These oligonucleotides can be administered in conjunction with an immunostimulatory peptide or antigen. Methods for modulating an immune response upon administration of the oligonucleotide are also disclosed. In addition, an in vitro screening method to identify oligonucleotides with immunostimulatory activity is provided.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: July 8, 2003
    Assignee: Dynavax Technologies Corporation
    Inventors: Eyal Raz, Mark Roman, Dino Dina
  • Methods of treating IgE-associated disorders and compositions for use therein
    Publication number: 20030064064
    Abstract: The present invention provides methods of treating IgE-associated disorders and compositions for use therein. The methods are particularly useful in treatment of allergies and allergy-related disorders. The methods generally comprise administering an IgE inhibitor (such as anti-IgE antibody) and an antigen and/or immunostimulatory polynucleotide sequence (ISS). These combination methods offer significant advantages, such as allowing more aggressive therapy while reducing unwanted side effects, such as anaphylaxis.
    Type: Application
    Filed: August 6, 2002
    Publication date: April 3, 2003
    Inventor: Dino Dina
  • Immunomodulatory formulations and methods for use thereof
    Publication number: 20030059773
    Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a nonbiodegradable microcarrier or nanocarrier.
    Type: Application
    Filed: August 10, 2001
    Publication date: March 27, 2003
    Inventors: Gary Van Nest, Stephen Tuck, Karen L. Fearon, Dino Dina
  • Immunomodulatory polynucleotides and methods of using the same
    Publication number: 20030049266
    Abstract: The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.
    Type: Application
    Filed: December 27, 2001
    Publication date: March 13, 2003
    Inventors: Karen L. Fearon, Dino Dina
  • Methods for detecting human immunodeficiency virus nucleic acid
    Patent number: 6531276
    Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: March 11, 2003
    Assignee: Chiron Corporation
    Inventors: Paul A. Luciw, Dino Dina
  • Biodegradable immunomodulatory formulations and methods for use thereof
    Publication number: 20030022852
    Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or noncarrier.
    Type: Application
    Filed: August 10, 2001
    Publication date: January 30, 2003
    Inventors: Gary Van Nest, Stephen Tuck, Karen L. Fearon, Dino Dina