Patents by Inventor Dirk Brenner

Dirk Brenner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10822388
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: November 3, 2020
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Patent number: 10059317
    Abstract: A pressure control valve arrangement for controlling fluid pressure in a brake system of a vehicle includes two diaphragm valves and two electromagnetic control valves, activatable by an electronic control device, for the pilot control of the diaphragm valves. The two electromagnetic control valves have a double magnet with two magnet coils and magnet armatures and are actuatable by current being applied to the magnet coils. The housing has at least one pressure medium connection, connected to a service brake valve, for acting with pressure upon and/or relieving the pressure of the pressure control valve arrangement and at least one connection for connecting to a brake cylinder. A plane of symmetry of the mid-axes of the magnet coils of the double magnet is arranged in parallel and offset by the amount of an eccentricity, with respect to a mid-axis of the pressure medium connection.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: August 28, 2018
    Assignee: Bendix Commercial Vehicle Systems LLC
    Inventors: Jan Grebe, Dirk Brenner, Jochen Weippert, Wolfgang Rohn, Harald Jaehns
  • Publication number: 20180016320
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: May 1, 2017
    Publication date: January 18, 2018
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Patent number: 9670265
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: June 6, 2017
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Publication number: 20170120881
    Abstract: A pressure control valve arrangement for controlling fluid pressure in a brake system of a vehicle includes two diaphragm valves and two electromagnetic control valves, activatable by an electronic control device, for the pilot control of the diaphragm valves. The two electromagnetic control valves have a double magnet with two magnet coils and magnet armatures and are actuatable by current being applied to the magnet coils. The housing has at least one pressure medium connection, connected to a service brake valve, for acting with pressure upon and/or relieving the pressure of the pressure control valve arrangement and at least one connection for connecting to a brake cylinder. A plane of symmetry of the mid-axes of the magnet coils of the double magnet is arranged in parallel and offset by the amount of an eccentricity, with respect to a mid-axis of the pressure medium connection.
    Type: Application
    Filed: December 6, 2016
    Publication date: May 4, 2017
    Inventors: Jan Grebe, Dirk Brenner, Jochen Weippert, Wolfgang Rohn, Harald Jaehns
  • Patent number: 9624289
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: April 18, 2017
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Publication number: 20160327068
    Abstract: A quick-action bleeder valve device for a pneumatic actuator of a pneumatic system, includes: a housing; a first connection which is connectable to a chamber of the actuator, which chamber can be ventilated and bled; a second connection which is connectable directly or indirectly to a compressed air source; a flow duct, formed in the housing, between the first connection and the second connection, the flow duct being constricted at a constriction point or throttle point by a reduced flow cross section; a diaphragm valve, arranged in the housing, including at least one diaphragm which interacts with a valve seat, wherein in an open position of the diaphragm valve, in which the diaphragm is lifted off from the valve seat, a pressure sink is connected to the first connection, and in a closed position of the diaphragm valve, in which the diaphragm is seated on the valve seat in a seal-forming fashion, this connection is interrupted; wherein at least part of a first effective area of the diaphragm, which effective
    Type: Application
    Filed: December 19, 2014
    Publication date: November 10, 2016
    Inventors: Jan GREBE, Thomas BEMETZ, Kai WERNER, Dirk BRENNER, Zsigmond CSOMA
  • Patent number: 9321824
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: April 26, 2016
    Assignee: Universal Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Patent number: 9228006
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 5, 2016
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Patent number: 9180849
    Abstract: A pressure control valve arrangement is described for controlling a fluid pressure in an ABS brake system of a vehicle such that, in the event of a tendency of individual wheels of the vehicle to lock, the brake pressure in at least one associated brake cylinder can be adaptively adjusted, including: a housing in which is formed at least one pressure-medium-conducting pressure medium duct and in which is provided a diversion of the flow of the pressure medium within the pressure medium duct from a portion of the pressure medium duct leading in one direction into a portion of the pressure medium duct leading in another direction, in which the pressure medium duct is produced together with the housing by primary forming, and in which the cross section of the pressure medium duct is oval and the major dimension of the oval cross section and the central axis of the pressure medium duct are arranged in a common plane, and the minor dimension of the oval cross section is perpendicular to the plane.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: November 10, 2015
    Assignee: KNORR-BREMSE SYSTEME FUER NUTZFAHRZEUGE GMBH
    Inventors: Jan Grebe, Dirk Brenner, Jochen Weippert, Wolfgang Rohn, Harald Jaehns
  • Publication number: 20150299292
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: October 22, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Patent number: 9139178
    Abstract: A pressure control valve arrangement is described for controlling the fluid pressure in an ABS brake system of a vehicle in such a way that, while there is a tendency of individual wheels of the vehicle to lock, the brake pressure in at least one associated brake cylinder can be adaptively adjusted, wherein at least one diaphragm valve is accommodated in a housing of the pressure control valve arrangement, said diaphragm valve having a diaphragm as the valve body, which diaphragm can be acted upon by introducing a pressure medium into a control chamber that is covered on the outside of the housing by a respective cover produced by primary shaping, such as injection molding, in such a way that the control chamber is formed between the diaphragm and the cover, and wherein blind holes, which extend in the cover substantially perpendicularly to the plane of the cover, are formed in the cover, the blind hole opening of at least one of said blind holes leading into the control chamber, and the blind hole opening of
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: September 22, 2015
    Assignee: KNORR-BREMSE SYSTEME FUER NUTZFAHRZEUGE GMBH
    Inventors: Jan Grebe, Dirk Brenner, Jochen Weippert, Wolfgang Rohn, Harald Jaehns
  • Publication number: 20150197551
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: July 16, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Patent number: 9039103
    Abstract: A pressure control valve arrangement for controlling a fluid pressure in an ABS brake system of a vehicle so that, while there is a tendency of individual wheels of the vehicle to lock, the brake pressure in at least one associated brake cylinder can be adaptively adjusted, including: a housing; and at least one diaphragm valve is accommodated in the housing, the diaphragm valve having a diaphragm as the valve body, which diaphragm can be acted upon by introducing pressure medium into a control chamber that is covered on the outside of the housing by a cover so that the control chamber is formed between the diaphragm and the cover, wherein at least one pressure medium channel carrying pressure medium is formed in the housing in the region of the cover, wherein at least one cover has at least one projection projecting into the pressure medium channel in the housing, a pressure medium guiding surface for directing the flow of the pressure medium carried in the pressure medium channel being formed on the project
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: May 26, 2015
    Assignee: Knorr-Bremse Systeme Fuer Nutzfahrzeuge GmbH
    Inventors: Jan Grebe, Dirk Brenner, Jochen Weippert, Wolfgang Rohn, Harald Jaehns
  • Publication number: 20150139995
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Patent number: 8918262
    Abstract: A pressure control device of a vehicle, including a pressure controller of a fluid pressure brake system for brake slip-dependent control, including a relay valve having a supply port supplied by a supply pressure, a venting port connected to a pressure sink, a control port and at least two working ports, in which a working port is assigned to at least one brake cylinder and the other working port is assigned to at least one brake cylinder of another wheel, in which each working port of the relay valve is connected to a 2/2-way valve controlled by a control unit and assigned to a respective vehicle side and establishes a connection between the relevant working port and the assigned brake cylinder or blocks the connection, depending on control unit actuation, and in which the control port of the relay valve is connectable to a brake control pressure formed in accordance with the braking input, to a supply pressure of a pressure reservoir or to a pressure sink by a valve system formed by one 3/2-way or two 2/2-
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: December 23, 2014
    Assignee: Knorr-Bremse Systeme fuer Nutzfahrzeuge GmbH
    Inventors: Friedbert Roether, Adnan Mustapha, Gerhard Wieder, Dirk Brenner
  • Publication number: 20130281356
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 24, 2013
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Publication number: 20130073165
    Abstract: A pressure control device of a vehicle, including a pressure controller of a fluid pressure brake system for brake slip-dependent control, including a relay valve having a supply port supplied by a supply pressure, a venting port connected to a pressure sink, a control port and at least two working ports, in which a working port is assigned to at least one brake cylinder and the other working port is assigned to at least one brake cylinder of another wheel, in which each working port of the relay valve is connected to a 2/2-way valve controlled by a control unit and assigned to a respective vehicle side and establishes a connection between the relevant working port and the assigned brake cylinder or blocks the connection, depending on control unit actuation, and in which the control port of the relay valve is connectable to a brake control pressure formed in accordance with the braking input, to a supply pressure of a pressure reservoir or to a pressure sink by a valve system formed by one 3/2-way or two 2/2-
    Type: Application
    Filed: March 8, 2011
    Publication date: March 21, 2013
    Inventors: Friedbert Roether, Adnan Mustapha, Gerhard Wieder, Dirk Brenner
  • Publication number: 20120181852
    Abstract: A pressure control valve arrangement for controlling a fluid pressure in an ABS brake system of a vehicle so that, while there is a tendency of individual wheels of the vehicle to lock, the brake pressure in at least one associated brake cylinder can be adaptively adjusted, including: a housing; and at least one diaphragm valve is accommodated in the housing, the diaphragm valve having a diaphragm as the valve body, which diaphragm can be acted upon by introducing pressure medium into a control chamber that is covered on the outside of the housing by a cover so that the control chamber is formed between the diaphragm and the cover, wherein at least one pressure medium channel carrying pressure medium is formed in the housing in the region of the cover, wherein at least one cover has at least one projection projecting into the pressure medium channel in the housing, a pressure medium guiding surface for directing the flow of the pressure medium carried in the pressure medium channel being formed on the project
    Type: Application
    Filed: June 24, 2010
    Publication date: July 19, 2012
    Inventors: Jan Grebe, Dirk Brenner, Jochen Weippert, Wolfgang Rohn, Harald Jaehns
  • Publication number: 20120175944
    Abstract: A pressure control valve arrangement is described for controlling the fluid pressure in an ABS brake system of a vehicle in such a way that, while there is a tendency of individual wheels of the vehicle to lock, the brake pressure in at least one associated brake cylinder can be adaptively adjusted, wherein at least one diaphragm valve is accommodated in a housing of the pressure control valve arrangement, said diaphragm valve having a diaphragm as the valve body, which diaphragm can be acted upon by introducing a pressure medium into a control chamber that is covered on the outside of the housing by a respective cover produced by primary shaping, such as injection molding, in such a way that the control chamber is formed between the diaphragm and the cover, and wherein blind holes, which extend in the cover substantially perpendicularly to the plane of the cover, are formed in the cover, the blind hole opening of at least one of said blind holes leading into the control chamber, and the blind hole opening of
    Type: Application
    Filed: June 24, 2010
    Publication date: July 12, 2012
    Inventors: Jan Grebe, Dirk Brenner, Jochen Weippert, Wolfgang Rohn, Harald Jaehns