Publication number: 20230303664
Abstract: The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2, a strategy for an enhanced block of the homotrimeric viral spike proteins by symmetry-matching VHH-fusions, implementations of this strategy, as well as VHH antibodies for sensitive detection of SARS-CoV2-infections.
Type:
Application
Filed:
July 29, 2021
Publication date:
September 28, 2023
Applicant:
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Inventors:
Dirk GÖRLICH, Volker CORDES, Thomas GÜTTLER, Philip GUNKEL, Renate REES, Jens KRULL, Kathrin GREGOR, Waltraud TAXER, Leonie NEUMANN, Tino PLEINER, Bianka MUSSIL, Ulrike TEICHMANN, Aksu METIN, Oleh RYMARENKO, Jürgen SCHÜNEMANN, Matthias DOBBELSTEIN, Kim Maren STEGMANN, Antje DICKMANNS
Publication number: 20230287087
Abstract: The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2, a strategy for an enhanced block of the homotrimeric viral spike proteins by symmetry-matching VHH-fusions, implementations of this strategy, as well as VHH antibodies for sensitive detection of SARS-CoV2-infections.
Type:
Application
Filed:
July 29, 2021
Publication date:
September 14, 2023
Applicant:
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Inventors:
Dirk GÖRLICH, Volker CORDES, Thomas GÜTTLER, Philip GUNKEL, Renate REES, Jens KRULL, Kathrin GREGOR, Waltraud TAXER, Leonie NEUMANN, Tino PLEINER, Bianka MUSSIL, Ulrike TEICHMANN, Aksu METIN, Oleh RYMARENKO, Jürgen SCHÜNEMANN, Matthias DOBBELSTEIN, Kim Maren STEGMANN, Antje DICKMANNS