Abstract: A feeding screw machine for feeding a processing screw machine comprises a housing with at least two housing bores formed therein and screw shafts rotatably arranged in the at least two housing bores. The at least two housing bores and the at least two screw shafts define a free volume in a respective cross-sectional plane, which decreases monotonically at least in some regions for continuous compression of a material in a conveying direction. This enables an improved supply of material with a low bulk density.

Abstract: The present invention relates to a method for treating a liquid sample comprising at least one diagnostic assay reagent after use. The present invention further relates to a tablet, a purified liquid sample, a diagnostic assay reagent, a waste water treatment system, a kit and uses thereof for treating the said liquid sample.

Abstract: The present invention relates to new isoindolinone or isobenzofuranone substituted indoles and derivatives of formula (I) wherein the groups R1 to R7, R10 and n have the meanings given in the claims and specification, their use as inhibitors of RAS-family proteins and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: The present invention encompasses compounds of formula (I) wherein the groups R1 to R7 have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: The present invention encompasses compounds of formula (I), wherein the groups R1 to R7 have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: An air passenger bridge with a coupling module for coupling to an aircraft, wherein the coupling module has a floor device. The floor device has a front edge, whereas said floor device with said front edge can be traveled towards a fuselage of an aircraft in a region below an aircraft door, and wherein a safety device is configured to avoid a collision of the floor device with the aircraft door. The safety device has at least one contactlessly acting proximity sensor that is integrated in the floor device.

Abstract: The present invention encompasses compounds of formula (I), wherein the groups R1 to R7 have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: An air passenger bridge with a coupling module for coupling to an aircraft, wherein the coupling module has a floor device. The floor device has a front edge, whereas said floor device with said front edge can be traveled towards a fuselage of an aircraft in a region below an aircraft door, and wherein a safety device is provided that is configured to avoid a collision of the floor device with the aircraft door. The safety device has at least one contactlessly acting proximity sensor that is integrated in the floor device.

Abstract: The sources of emails sent from mobile devices using wireless email protocols can be identified. In one embodiment, the invention includes receiving a simple mail transfer protocol (SMTP)-formatted email sent from a mobile device as an HTTP request. An SMTP-compliant header identifying the mobile device is examined, that was inserted into the HTTP request using information contained in one or more HTTP headers of the HTTP request. Then, an email data loss prevention (DLP) policy specific to mobile devices is applied to the received email.

Abstract: A computer-implemented method for configuring computing systems may include (1) detecting an event associated with a client device that potentially impacts a group to which the client device is assigned and, in response to detecting the event, (2) discovering at least one attribute of the client device that has the potential to impact the client device's group assignment, (3) identifying at least one rule that defines conditions for assigning client devices to groups, (4) determining, by applying the rule to the discovered attribute of the client device, that the client device's group assignment should be modified, and (5) modifying, in response to determining that the client device's group assignment should be modified, the client device's group assignment based on the discovered attribute of the client device. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Disclosed are compounds of general formula (I) wherein the groups R1 to R3 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.

Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Abstract: The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having at least one selective nucleotide complementary to only one variant of the target sequence and incorporating both a nucleotide with a base covalently modified at the exocyclic amino group and a modified phosphate.

Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Abstract: A mobile device identifies a secure document that contains one or more context rules that correspond to the secure document. The mobile device determines whether a user is authorized to access the secure document based on the one or more context rules. The mobile device identifies an original document format for the secure document if the user is authorized to access the secure document and identifies an authorized application installed on the mobile device for accessing the secure document using the original document format. The authorized application corresponds to the original document format of the secure document. The mobile device sends the secure document to the authorized application.

Abstract: A method and apparatus for identity consolidation for a plurality of electronic identities is described. In one embodiment, the method includes receiving user identification data extracted from an electronic communication, the user identification data corresponding to an unknown identity of a sender of the electronic communication. The method further includes determining a known identity for the sender using the user identification data extracted from the electronic communication and associating the known identity with the unknown identity of the sender of the electronic communication. In one embodiment, an association between the known identity and the unknown identity is maintained to determine whether parties of subsequent information transfers are authorized to participate in the information transfers.

Abstract: The present invention encompasses compounds of general Formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Abstract: The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula 1 are produced in a stereocontrolled manner.

Abstract: The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having at least one selective nucleotide complementary to only one variant of the target sequence and incorporating both a nucleotide with a base covalently modified at the exocyclic amino group and a modified phosphate.

Abstract: Disclosed are compounds of general formula (I) wherein the groups R1 to R3 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.