Patents by Inventor Dirk Kosemund

Dirk Kosemund has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METASUBSTITUTED THIAZOLIDINONES, THEIR MANUFACTURE AND USE AS A DRUG
    Publication number: 20100048891
    Abstract: Thiazolidinones of general formula (I) production thereof and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.
    Type: Application
    Filed: April 29, 2009
    Publication date: February 25, 2010
    Inventors: Klause SCHULZE, Knut Eis, Lars Wortmann, Dirk Kosemund, Olaf Prien, Gerhard Siemeister, Holger Hess-Stumpp, Uwe Eberspaecher, Dominic E.A. Brittain, Imadul Islam
  • 2-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-YL SULFAMATE WITH AN ANTI-TUMOUR ACTION
    Publication number: 20090221841
    Abstract: The invention relates to the use of 2-substituted estra-1,3,5(10)-triene-3-yl sulfamates of general formula I, in addition to their pharmaceutically acceptable salts for producing a medicament. Said compounds have an anti-tumour action.
    Type: Application
    Filed: September 22, 2008
    Publication date: September 3, 2009
    Applicant: Sterix Limited
    Inventors: Alexander HILLISCH, Olaf Peters, Christian Gege, Wilko Regenhardt, Dirk Kosemund, Gerhard Siemeister, Eberhard Unger, Ulrich Bothe
  • AZAINDOLES AS INHIBITORS OF SOLUBLE ADENYLATE CYCLASE
    Publication number: 20090098189
    Abstract: The present invention relates to azaindoles of general formula I, a method for the production thereof, and to the use thereof for the production of pharmaceutical compositions.
    Type: Application
    Filed: September 2, 2008
    Publication date: April 16, 2009
    Inventors: Bernd BUCHMANN, Michael Haerter, Yolanda Cancho-Grande, Dirk Kosemund, Hartmut Schirok, Duy Nguyen, Martin Fritsch
  • Thiazolidinones, their production and use as pharmaceutical agents
    Patent number: 7511059
    Abstract: The invention relates to thiazolidinones of general formula (I) their production and use as inhibitors of polo-like kinases (Plk) for treating various diseases.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: March 31, 2009
    Assignee: Schering Ag
    Inventors: Volker Schulze, Knut Eis, Lars Wortmann, Dirk Kosemund, Olaf Prien, Gerhard Siemeister, Holger Hess-Stumpp, Uwe Eberspaecher, Damian O Arnaiz
  • Arylmethylene Substituted N-Acyl-Beta-Amino Alcohols
    Publication number: 20090082372
    Abstract: The present invention relates to arylmethylene substituted N-Acyl-?-amino alcohols of the formula I in which Y is selected from the aryl or heteroaryl groups: and R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
    Type: Application
    Filed: July 24, 2008
    Publication date: March 26, 2009
    Inventors: Lars WORTMANN, Marcus Koppitz, Bernd Menzenbach, Dirk Kosemund, Norbert Schmees, Hans-Peter Muhn, Thomas Frenzel, Florian Peter Liesener, Anna Schrey, Ronald Kuehne
  • Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
    Patent number: 7504410
    Abstract: This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: November 28, 2003
    Date of Patent: March 17, 2009
    Assignee: Schering Aktiengesellschaft
    Inventors: Judi Bryant, Monica J. Kochanny, Shendong Yuan, Seock-Kyu Khim, Brad O. Buckman, Damian O. Arnaiz, Ulf Bomer, Hans Briem, Peter Esperling, Christoph Huwe, Joachim Kuhnke, Martina Schafer, Lars Wortmann, Dirk Kosemund, Emil Eckle, Richard I. Feldman, Gary B. Phillips
  • ARYLMETHYLEN SUBSTITUTED N-ACYL-Y-AMINOALCOHOLS
    Publication number: 20080287493
    Abstract: The present invention relates to arylmethylen substituted N-acyl-Y-aminoalcohols of the general formula I in which Q, X, W, R1, R2, R3, R4 and R5 have the meaning as defined in the description. The compounds according to the invention are effective FSH modulators and can be used for example for fertility regulation in men or in women.
    Type: Application
    Filed: April 24, 2008
    Publication date: November 20, 2008
    Inventors: Lars Wortmann, Bernd Menzenbach, Marcus Koppitz, Dirk Kosemund, Hans-Peter Muhn, Anna Schrey, Ronald Kuhne, Thomas Frenzel, Florian Peter Liesener
  • Inhibitors of soluble adenylate cyclase
    Patent number: 7449459
    Abstract: The invention relates to compounds of general formula I as well as the production and use thereof as a medication.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: November 11, 2008
    Assignee: Bayer Schering Pharma AG
    Inventors: Bernd Buchmann, Dirk Kosemund, Bernd Menzenbach, Martin Fritsch
  • SULFONYLTRYPTOPHANOLS
    Publication number: 20080255117
    Abstract: The present invention relates to sulfonyltryptophanols of the general formula I, in which Q, X, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH receptor antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
    Type: Application
    Filed: February 29, 2008
    Publication date: October 16, 2008
    Inventors: Lars WORTMANN, Bernd Menzenbach, Marcus Koppitz, Dirk Kosemund, Hans Peter Muhn, Anna Schrey, Ronald Kuehne, Thomas Frenzel, Florian Peter Liesener
  • 2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action
    Patent number: 7427610
    Abstract: Disclosed are compounds of formula I and use thereof in a method of treating a tumor disease that can be influenced positively by the inhibition of tubulin polymerization.
    Type: Grant
    Filed: February 19, 2004
    Date of Patent: September 23, 2008
    Assignee: Sterix Limited
    Inventors: Alexander Hillisch, Olaf Peters, Christian Gege, Wilko Regenhardt, Dirk Kosemund, Gerhard Siemeister, Eberhard Unger, Ulrich Bothe
  • 1,2-DIARYLACETYLENE DERIVATIVES OF ACYLTRYPTOPHANOLS
    Publication number: 20080221195
    Abstract: The present invention relates to acyltryptophanols of the general formula I, in which Q, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
    Type: Application
    Filed: December 12, 2007
    Publication date: September 11, 2008
    Inventors: Lars Wortmann, Hans-Peter Muhn, Bernd Menzenbach, Anna Schrey, Ronald Kuehne, Dirk Kosemund, Marcus Koppitz
  • BICYCLIC ACYLTRYPTOPHANOLS
    Publication number: 20080207728
    Abstract: The present invention relates to acyltryptophanols of the general formula I, in which Q, V, X, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
    Type: Application
    Filed: December 14, 2007
    Publication date: August 28, 2008
    Inventors: Lars Wortmann, Bernd Menzenbach, Marcus Koppitz, Dirk Kosemund, Hans-Peter Muhn, Anna Schrey, Ronald Kuehne, Thomas Frenzel, Florian Peter Liesener
  • 9-?-substituted estratrienes as selectively active estrogens
    Patent number: 7414043
    Abstract: This invention describes the new 9?-substituted estratrienes of general formula I in which R3, R7, R7?, R13, R16 as well as R17 and R17? have the meanings that are indicated in the description and R9 means a straight-chain or branched-chain, optionally partially or completely halogenated alkenyl radical with 2 to 6 carbon atoms, an ethinyl or prop-1-inyl radical, as pharmaceutical active ingredients that exhibit in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo preferably a preferential action on the ovary in comparison to the uterus, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds. The invention also describes the use of these compounds for treating estrogen-deficiency-induced diseases and conditions.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: August 19, 2008
    Assignee: Schering AG
    Inventors: Dirk Kosemund, Gerd Mueller, Alexander Hillisch, Karl-Heinrich Fritzemeier, Peter Muhn
  • SUBSTITUTED ESTRATRIENES AS SELECTIVELY ACTIVE ESTROGENS
    Publication number: 20080132476
    Abstract: This invention describes the new 9?-substituted estratrienes of general formula I in which R3, R7, R7?, R13, R16 as well as R17 and R17? have the meanings that are indicated in the description and R9 means a straight-chain or branched-chain, optionally partially or completely halogenated alkenyl radical with 2 to 6 carbon atoms, an ethinyl or prop-1-inyl radical, as pharmaceutical active ingredients that exhibit in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo preferably a preferential action on the ovary in comparison to the uterus, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds. The invention also describes the use of these compounds for treating estrogen-deficiency-induced diseases and conditions.
    Type: Application
    Filed: February 7, 2008
    Publication date: June 5, 2008
    Inventors: Dirk KOSEMUND, Gerd Mueller, Alexander Hillisch, Karl-Heinrich Fritzemeier, Peter Muhn
  • Inhibitors of soluble adenylate cyclase
    Publication number: 20070259872
    Abstract: The invention relates to compounds of general formula I as well as the production and use thereof as a medication.
    Type: Application
    Filed: March 23, 2007
    Publication date: November 8, 2007
    Inventors: Bernd Buchmann, Dirk Kosemund, Bernd Menzenbach, Martin Fritsch
  • Inhibitors of soluble adenylate cyclase
    Publication number: 20070232605
    Abstract: The invention relates to compounds of general formula I as well as the production and use thereof as a medication.
    Type: Application
    Filed: March 23, 2007
    Publication date: October 4, 2007
    Inventors: Bernd Buchmann, Dirk Kosemund, Bernd Menzenbach, Martin Fritsch
  • Inhibitors of soluble adenylate cyclase
    Publication number: 20070225284
    Abstract: The invention relates to compounds of general formula I as well as the production and use thereof as a medication.
    Type: Application
    Filed: March 23, 2007
    Publication date: September 27, 2007
    Inventors: Bernd Buchmann, Dirk Kosemund, Bernd Menzenbach, Martin Fritsch
  • Prodrugs of ERbeta-selective substances, processes for their preparation and pharmaceutical compositions comprising these compounds
    Publication number: 20070123500
    Abstract: The present invention makes available prodrugs of 9?-substituted oestratrienes of the general formula (I) in which the group Z is bonded to the steroid, processes for their preparation, pharmaceutical compositions which comprise these compounds and use thereof. The compounds of the general formula I according to the invention do not bind to the oestrogen receptor a and/or ?. They bind to carboanhydrases and inhibit these enzymes.
    Type: Application
    Filed: November 28, 2006
    Publication date: May 31, 2007
    Inventors: Gerd Mueller, Dirk Kosemund, Ralf Wyrwa
  • Acyltryptophanols
    Publication number: 20070060573
    Abstract: The present patent application relates to acyltryptophanols of the general formula I, in which Q, X, Y, W, R1, R2, R3, R4, R5, R8 have the meanings stated in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
    Type: Application
    Filed: August 9, 2006
    Publication date: March 15, 2007
    Inventors: Lars Wortmann, Arwed Cleve, Bernd Menzenbach, Hans-Peter Muhn, Gernot Langer, Anna Schrey, Ronald Kuehne, Marcu Koppitz, Dirk Kosemund
  • Metasubstituted thiazolidinones, their manufacture and use as a drug
    Publication number: 20070015759
    Abstract: This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.
    Type: Application
    Filed: December 14, 2005
    Publication date: January 18, 2007
    Inventors: Volker Schulze, Knut Eis, Lars Wortmann, Dirk Kosemund, Olaf Prien, Gerhard Siemeister, Holger Hess-Stumpp, Uwe Eberspaecher, Dominic Brittain, Imadul Islam