Patents by Inventor Dirk Wybe Grijpma
Dirk Wybe Grijpma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220105038Abstract: The invention relates to a process for preparing PCL-comprising microparticles, to microparticles obtainable by said process, to gel hence obtained and to several uses of the gel such as for the preparation of a medicament for treating a skin abnormality or disfigurement, and/or for controlling bladder function and/or controlling gastric reflux and/or for treating erectile dysfunction and/or for treating vocal cords. The gel may also be used for cosmetic applications.Type: ApplicationFiled: December 14, 2021Publication date: April 7, 2022Applicant: AQTIS I.P. B.V.Inventors: Henderikus Super, Paul Willem Mijnen, Pieter Gerard Zijlstra, Dirk Wybe Grijpma
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Publication number: 20200276358Abstract: The invention is directed to biocompatible composite materials for medical applications such as tissue regeneration. In particular, the present invention is directed to biocompatible composite materials that may be used for the treatment of lost bone or bone defects. According to the invention there is provided an anhydrous biocompatible composite material comprising a biodegradable polymeric material and a granular synthetic material, wherein the polymeric material essentially consists of at least one block copolymer that comprises at least one hydrophilic block and at least one hydrophobic block.Type: ApplicationFiled: February 24, 2020Publication date: September 3, 2020Applicant: Kuros Biosciences B.V.Inventors: Florence DE GROOT-BARRERE, Davide BARBIERI, Dirk Wybe GRIJPMA, Joost DE BRUIJN
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Patent number: 9913932Abstract: The present invention relates to methods for providing polymeric composites with bone forming, such as with osteogenic and/or osteoinductive and/or osteoconductive, properties. The present invention further relates to polymeric composites provided by the present method and the use of thereof for bone implants, or grafts, specifically the use thereof for orbital floor reconstruction. Specifically, the present invention relates to methods for providing a composite with bone forming properties, the method comprises the steps of: a) providing a liquid, or liquefied, polymeric composition of homopolymers or copolymers of 1,3-trimethylene carbonate (TMC); b) adding to said liquid, or liquefied, polymeric composition one or more agents with osteogenic and/or osteoinductive and/or osteoconductive properties thereby providing a dispersion of said agents in said liquid or liquefied polymeric composition; and c) crosslinking the product obtained, thereby providing a composite with bone forming properties.Type: GrantFiled: October 26, 2011Date of Patent: March 13, 2018Assignees: UNIVERSITEIT TWENTE, RUKSUNIVERSITEIT GRONINGEN, ACADEMISCH ZIEKENHUIS GRONINGENInventors: Dirk Wybe Grijpma, Rudolf Robert Maria Bos, Anne Cornelis Van Leeuwen
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Publication number: 20180028720Abstract: The invention is directed to biocompatible composite materials for medical applications such as tissue regeneration. In particular, the present invention is directed to biocompatible composite materials that may be used for the treatment of lost bone or bone defects. According to the invention there is provided an anhydrous biocompatible composite material comprising a biodegradable polymeric material and a granular synthetic material, wherein the polymeric material essentially consists of at least one block copolymer that comprises at least one hydrophilic block and at least one hydrophobic block.Type: ApplicationFiled: March 14, 2016Publication date: February 1, 2018Applicants: Kuros Biosciences B.V., UNIVERSITEIT TWENTEInventors: Florence DE GROOT-BARRERE, Davide BARBIERI, Dirk Wybe GRIJPMA, Joost DE BRUIJN
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Publication number: 20150004206Abstract: The invention relates to a process for preparing PCL-comprising microparticles, to microparticles obtainable by said process, to gel hence obtained and to several uses of the gel such as for the preparation of a medicament for treating a skin abnormality or disfigurement, and/or for controlling bladder function and/or controlling gastric reflux and/or for treating erectile dysfunction and/or for treating vocal cords. The gel may also be used for cosmetic applications.Type: ApplicationFiled: July 1, 2014Publication date: January 1, 2015Inventors: Henderikus Supèr, Paul Willem Mijnen, Pieter Gerard Zijlstra, Dirk Wybe Grijpma
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Publication number: 20140348773Abstract: The present invention relates to methods for providing polymeric composites with bone forming, such as with osteogenic and/or osteoinductive and/or osteoconductive, properties. The present invention further relates to polymeric composites provided by the present method and the use of thereof for bone implants, or grafts, specifically the use thereof for orbital floor reconstruction. Specifically, the present invention relates to methods for providing a composite with bone forming properties, the method comprises the steps of: a) providing a liquid, or liquefied, polymeric composition of homopolymers or copolymers of 1,3-trimethylene carbonate (TMC); b) adding to said liquid, or liquefied, polymeric composition one or more agents with osteogenic and/or osteoinductive and/or osteoconductive properties thereby providing a dispersion of said agents in said liquid or liquefied polymeric composition; and c) crosslinking the product obtained, thereby providing a composite with bone forming properties.Type: ApplicationFiled: October 26, 2011Publication date: November 27, 2014Applicants: UNIVERSITEIT TWENTE, ACADEMISCH ZIEKENHUIS GRONINGEN, RIJKSUNIVERSITEIT GRONINGENInventors: Dirk Wybe Grijpma, Rudolf Robert Maria Bos, Anne Cornelis Van Leeuwen
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Patent number: 8829069Abstract: The present invention relates to methods for preparing a degradable polymer network. The methods for preparing a degradable polymer network comprise a) preparing a polymer composition comprising monomers of cyclic carbonates and/or cyclic esters and/or linear carbonates and/or linear esters and/or cyclic ethers and/or linear hydroxycarboxylic acids at a temperature between 20° C. and 200° C.; b) adding a cross-linking reagent comprising at least one double or triple C—C bond and/or a cross-linking radical initiator; c) processing the polymer composition (that contains the crosslinking reagent into a desired shape; d) Crosslinking by irradiating the mixture. Further, the present invention relates to a degradable polymer network. Furthermore, the present invention relates to the use of the degradable polymer network.Type: GrantFiled: May 26, 2010Date of Patent: September 9, 2014Assignee: Medisse B.V.Inventors: Dirk Wybe Grijpma, Jan Feijen, Erhan Bat
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Patent number: 8795694Abstract: The invention relates to a process for preparing PCL-comprising microparticles, to microparticles obtainable by said process, to gel hence obtained and to several uses of the gel such as for the preparation of a medicament for treating a skin abnormality or disfigurement, and/or for controlling bladder function and/or controlling gastric reflux and/or for treating erectile dysfunction and/or for treating vocal cords. The gel may also be used for cosmetic applications.Type: GrantFiled: July 23, 2008Date of Patent: August 5, 2014Assignee: Aqtis I.P. B.V.Inventors: Henderikus Supèr, Paul Willem Mijnen, Pieter Gerard Zijlstra, Dirk Wybe Grijpma
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Publication number: 20130123384Abstract: The present invention relates to methods for preparing a degradable polymer network. The methods for preparing a degradable polymer network comprise a) preparing a polymer composition comprising monomers of cyclic carbonates and/or cyclic esters and/or linear carbonates and/or linear esters and/or cyclic ethers and/or linear hydroxycarboxylic acids at a temperature between 20° C. and 200° C.; b) adding a cross-linking reagent comprising at least one double or triple C—C bond and/or a cross-linking radical initiator; c) processing the polymer composition (that contains the crosslinking reagentj into a desired shape; d) Crosslinking by irradiating the mixture. Further, the present invention relates to a degradable polymer network. Furthermore, the present invention relates to the use of the degradable polymer network.Type: ApplicationFiled: May 26, 2010Publication date: May 16, 2013Applicant: UNIVERSITEIT TWENTEInventors: Dirk Wybe Grijpma, Jan Feijen, Erhan Bat
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Publication number: 20120322953Abstract: Functionalized prepolymers and biocompatible polymer networks are disclosed, especially biodegradable polymer networks obtainable by polymerization of the functionalized prepolymers by the example ultraviolet (UV), redox, and/or heat radical polymerization. Functionalized prepolymers (macromers) are obtainable by reaction of a prepolymer comprising at least one alcohol, amine, and/or sulfhydril group, with an unsaturated mono-esterified dicarbonic acid, especially fumanic acid mono-ethyl ester.Type: ApplicationFiled: March 13, 2012Publication date: December 20, 2012Applicant: DSM IP ASSETS B.V.Inventors: Dirk Wybe GRIJPMA, Qingpu Hou, Jan Feijen
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Publication number: 20100215702Abstract: The invention relates to a process for preparing PCL-comprising microparticles, to microparticles obtainable by said process, to gel hence obtained and to several uses of the gel such as for the preparation of a medicament for treating a skin abnormality or disfigurement, and/or for controlling bladder function and/or controlling gastric reflux and/or for treating erectile dysfunction and/or for treating vocal cords. The gel may also be used for cosmetic applications.Type: ApplicationFiled: July 23, 2008Publication date: August 26, 2010Inventors: Henderikus Supèr, Paul Willem Mijnen, Pieter Gerard Zijlstra, Dirk Wybe Grijpma
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Patent number: 7572838Abstract: The present invention relates to methods for providing shaped biodegradable and elastomeric structures of (co)polymers of 1,3trimethylene carbonate (TMC) with improved (mechanical) properties which can be used for tissue or tissue component support, generation or regeneration. Such shaped biodegradable elastomeric structures are obtainable by forming homopolymers and/or copolymers of 1,3-trimethylene carbonate (TMC) into a desired shape and irradiating said desired shape with actinic radiation in an inert atmosphere.Type: GrantFiled: November 5, 2003Date of Patent: August 11, 2009Assignee: Universiteit TwenteInventors: Dirk Wybe Grijpma, Ana Paula Gomes Moreira Pêgo, Jan Feijen
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Publication number: 20080267901Abstract: Functionalized prepolymers and biocompatible polymer networks are disclosed, especially biodegradable polymer networks obtainable by polymerization of the functionalized prepolymers by for example ultraviolet (UV), redox, and/or heat radical polymerization. Functionalized prepolymers (macromers) are obtainable by reaction of a prepolymer comprising at least one alcohol, amine, and/or sulfhydril group, with an unsaturated mono-esterified dicarbonic acid, especially fumaric acid mono-ethyl ester.Type: ApplicationFiled: October 15, 2003Publication date: October 30, 2008Inventors: Dirk Wybe Grijpma, Qingpu Hou, Jan Feijen
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Publication number: 20040086544Abstract: The invention relates to a process for loading a polymer with one or more bioactive agents, using a wet spinning technique. The invention further relates to a polymer loaded with one or more bioactive agents, obtainable by said process and to the use thereof as a carrier for controlled drug release or as scaffold for tissue engineering.Type: ApplicationFiled: October 28, 2003Publication date: May 6, 2004Applicant: Chienna B.V.Inventors: Jeroen Mattijs Bezemer, Clemens Antoni van Blitterswijk, Jan Feijen, Dirk Wybe Grijpma
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Patent number: 6685957Abstract: A fibrous polymer implant loaded with one or more bioactive agents is prepared using a wet spinning technique. Preferably, an aqueous solution of bioactive agent is added to a solution of amphiphilic block copolymer containing hydrophilic blocks such as polyalkylene glycol and hydrophobic blocks such as an aromatic ester dissolved in a first solvent immiscible with water to form an emulsion. The emulsion is injected through a nozzle into a second solvent miscible with the first solvent in which the copolymer is essentially insoluble to form a solid copolymer fiber loaded with the bioactive agent. The fiber is shaped into an implant. Water content of the aqueous solution of bioactive agent affects rate of release of the bioactive agent in vivo. Bioactive agents include peptides, oligopeptides, polypeptides and proteins. The implant may be used as a carrier for controlled drug release or as a scaffold for tissue engineering.Type: GrantFiled: September 29, 2000Date of Patent: February 3, 2004Assignee: Chienna B.V.Inventors: Jeroen Mattijs Bezemer, Clemens Antoni van Blitterswijk, Jan Feijen, Dirk Wybe Grijpma
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Patent number: 5672367Abstract: The invention relates to a biodegradable chewing gum comprising one or more conventional chewing gum components and as gum base at least one biodegradable polymer selected from the group of polyesters and polycarbonates.Type: GrantFiled: October 13, 1995Date of Patent: September 30, 1997Assignee: Rijksuniversiteit te GroningenInventors: Dirk Wybe Grijpma, Johannes Fredericus Laimbock, Albert Johan Pennings