Patents by Inventor Dmitry Malkov

Dmitry Malkov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOWN-REGULATION OF THE CYTOSOLIC DNA SENSOR PATHWAY
    Publication number: 20210246472
    Abstract: Methods for increasing targeted genome editing by down-regulating proteins involved in cytosolic DNA sensing pathways.
    Type: Application
    Filed: August 20, 2019
    Publication date: August 12, 2021
    Inventors: Nathan Zenser, Dmitry Malkov, Mark A. Gerber, Jill Ward
  • METHODS FOR GENERATING ENDOGENOUSLY TAGGED PROTEINS
    Publication number: 20180134759
    Abstract: The present disclosure provides a method for endogenously tagging an endogenous protein in a cell, and a cell comprising an endogenously tagged protein. Also described are cells produced using such a method and a kit comprising a cell having tagged endogenous protein.
    Type: Application
    Filed: July 19, 2017
    Publication date: May 17, 2018
    Inventors: Dmitry Malkov, Nathan Zenser, Deborah Vassar, Fan Zhang, Hongyi Zhang
  • USE OF ENDOGENOUS PROMOTERS TO EXPRESS HETEROLOGOUS PROTEINS
    Publication number: 20180105564
    Abstract: The present invention provides methods for using endogenous transcriptional control systems to regulate the expression of heterologous protein(s). In particular, targeted genome editing is used to integrate a sequence encoding the heterologous protein(s) in-frame with an endogenous coding sequence such that the expression of the heterologous and endogenous sequences is regulated by the endogenous control system.
    Type: Application
    Filed: May 31, 2017
    Publication date: April 19, 2018
    Inventors: Greg Davis, Dmitry Malkov, Nathan Zenser
  • USE OF ENDOGENOUS PROMOTERS TO EXPRESS HETEROLOGOUS PROTEINS
    Publication number: 20130065310
    Abstract: The present invention provides methods for using endogenous transcriptional control systems to regulate the expression of heterologous protein(s). In particular, targeted genome editing is used to integrate a sequence encoding the heterologous protein(s) in-frame with an endogenous coding sequence such that the expression of the heterologous and endogenous sequences is regulated by the endogenous control system.
    Type: Application
    Filed: April 13, 2011
    Publication date: March 14, 2013
    Applicant: SIGMA-ALDRICH CO., LLC
    Inventors: Greg Davis, Dmitry Malkov, Nathan Zenser
  • METHODS FOR GENERATING ENDOGENOUSLY TAGGED PROTEINS
    Publication number: 20130059388
    Abstract: The present disclosure provides a method for endogenously tagging an endogenous protein in a cell, and a cell comprising an endogenously tagged protein. Also described are cells produced using such a method and a kit comprising a cell having tagged endogenous protein.
    Type: Application
    Filed: April 13, 2011
    Publication date: March 7, 2013
    Applicant: SIGMA-ALDRICH CO., LLC
    Inventors: Dmitry Malkov, Nathan Zenser, Deborah Vassar, Fan Zhang, Hongyi Zhang
  • BIOSENSORS COMPRISING PROTEIN-BINDING DOMAINS AND FLUORESCENT PROTEINS
    Publication number: 20130059362
    Abstract: The present invention provides compositions and methods for monitoring cellular signal transduction events. In particular, signal transduction events may be monitored by the use of biosensors comprising protein-binding domains, which bind signal-transduction proteins, and fluorescent proteins. Provided herein, therefore, methods for detecting activation of signal transduction proteins or screening for agents that modulate the activity of signal transduction proteins. Also provided are cells comprising the biosensors; lentiviral particles comprising biosensor coding sequence; and kits comprising the lentiviral particles.
    Type: Application
    Filed: April 13, 2011
    Publication date: March 7, 2013
    Applicant: SIGMA-ALDRICH CO., LLC
    Inventors: John Fetter, Dmitry Malkov, Nathan Zenser, Keming Song