Patents by Inventor Dodda Mohan Rao

Dodda Mohan Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9000221
    Abstract: The present invention relates to processes for the preparation of 4?-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3?-methoxyacetophenone and intermediates thereof. The present invention also provides a process for purifying 4?-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3?-methoxyacetophenone to obtain the purity greater than about 98.0 area % to about 99.0 area % as measured by HPLC, preferably greater than about 99.0 area % to about 99.5 area %, more preferably greater about 99.5 area % to about 99.9 area %. individual impurities lower than about 0.15 area %, preferably lower than about 0.1% and total impurities lower than about 0.5 area % by HPLC.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: April 7, 2015
    Assignee: Symed Labs Limited
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy, Buthukuri Venkat Reddy
  • Publication number: 20140350285
    Abstract: The present invention relates to novel polymorphs of N-[2-amino-4-(4-fluorobenzylamino)-phenyl]carbamic acid ethyl ester, processes for preparing them, and pharmaceutical composition comprising them. In one aspect, the present invention relates to a novel crystalline polymorph of retigabine designated as crystalline Form I, characterized by XRPD having characteristic peaks at about 4.87, 5.04, 7.03, 9.74, 10.02, 11.6, 18.03, 19.9 and 28.5±0.2 degrees two-theta, which is substantially same as depicted in FIG. 1.
    Type: Application
    Filed: January 30, 2012
    Publication date: November 27, 2014
    Applicant: SYMED LABS LIMITED
    Inventors: Dodda Mohan Rao, Kirla Haritha
  • Patent number: 8835635
    Abstract: Disclosed herein is a stable amorphous form of vilazodone hydrochloride substantially free of crystalline forms, a process for the preparation, pharmaceutical compositions, and methods of treating thereof. Disclosed also herein are stable amorphous co-precipitates of vilazodone hydrochloride and a pharmaceutically acceptable excipient, methods for the preparation, pharmaceutical compositions, and method of treating thereof.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: September 16, 2014
    Assignee: Symed Labs Limited
    Inventors: Dodda Mohan Rao, Aadepu Jithender
  • Publication number: 20130324554
    Abstract: Disclosed herein is a stable amorphous form of vilazodone hydrochloride substantially free of crystalline forms, a process for the preparation, pharmaceutical compositions, and methods of treating thereof. Disclosed also herein are stable amorphous co-precipitates of vilazodone hydrochloride and a pharmaceutically acceptable excipient, methods for the preparation, pharmaceutical compositions, and method of treating thereof.
    Type: Application
    Filed: October 22, 2012
    Publication date: December 5, 2013
    Applicant: SYMED LABS LIMITED
    Inventors: Dodda MOHAN RAO, Aadepu JITHENDER
  • Publication number: 20130296608
    Abstract: The present invention relates to a novel stereospecific synthesis of (?)(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl pentan-3-ol an intermediate in the synthesis of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol.
    Type: Application
    Filed: January 27, 2011
    Publication date: November 7, 2013
    Applicant: SYMED LABS LIMITED
    Inventors: Dodda Mohan Rao, Pingili Krishnareddy, Pingili Ramachandrareddy, Kirla Haritha, Kolluru Srinivas
  • Patent number: 8546615
    Abstract: The present invention relates to solid racemic dapoxetine, solid dapoxetine S(+)enantiomer, processes for their preparation and their use in the pharmaceutically active compound dapoxetine acid addition salt, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: October 1, 2013
    Assignee: Symed Labs Limited
    Inventors: Dodda Mohan Rao, Pingili Krishnareddy, Aadepu Jithender
  • Publication number: 20130190501
    Abstract: The present invention relates to processes for the preparation of 4?-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3?-methoxyacetophenone and intermediates thereof. The present invention also provides a process for purifying 4?-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3?-methoxyacetophenone to obtain the purity greater than about 98.0 area % to about 99.0 area % as measured by HPLC, preferably greater than about 99.0 area % to about 99.5 area %, more preferably greater about 99.5 area % to about 99.9 area %. individual impurities lower than about 0.15 area %, preferably lower than about 0.1% and total impurities lower than about 0.5 area % by HPLC.
    Type: Application
    Filed: July 18, 2011
    Publication date: July 25, 2013
    Applicant: SYMED LABS LIMITED
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy, Buthukuri Venkat Reddy
  • Publication number: 20130172554
    Abstract: The present invention provides processes for the preparation of 4-{4-[5(S)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one which are simple, eco-friendly, cost-effective, reproducible, robust and are well amenable on industrial scale.
    Type: Application
    Filed: August 1, 2011
    Publication date: July 4, 2013
    Applicant: SYMED LABS LIMITED
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy, Ambati Anna Reddy, Buthukuri Venkat Reddy
  • Publication number: 20130150453
    Abstract: The present invention relates to solid racemic dapoxetine, solid dapoxetine S(+)enantiomer, processes for their preparation and their use in the pharmaceutically active compound dapoxetine acid addition salt, and pharmaceutical compositions thereof.
    Type: Application
    Filed: November 13, 2009
    Publication date: June 13, 2013
    Applicant: SYMED LABS LIMITED
    Inventors: Dodda Mohan Rao, Pingili Krishnareddy, Aadepu Jithender
  • Publication number: 20120220776
    Abstract: The present invention provides a novel process for the preparation of iloperidone using a novel intermediate. Thus, for example, 4-(3-chloropropoxy)-3-methoxybenzaldehyde is reacted with methyl magnesium iodide in ether and the reaction mass is heated for 6 hours at reflux temperature, the resulting mass is cooled to ambient temperature and then poured into a mixture of ice, water and dilute hydrochloric acid to produce 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanol, which is then subsequently converted to iloperidone.
    Type: Application
    Filed: November 19, 2009
    Publication date: August 30, 2012
    Applicant: SYMED LABS LIMITED
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy, Kanakuntla Chandana Reddy, Mohammad Rizwana
  • Publication number: 20120214986
    Abstract: The present invention relates to novel processes for the preparation of iron (III) carboxymaltose complex. Thus, for example, a mixture of one or more maltodextrins, ferric hydroxide and water is heated, the resulting iron maltodextrin complex is oxidized using an aqueous sodium hypochlorite solution, followed by maintaining at 25° C. to 125° C. to produce iron (III) carboxymaltose complex.
    Type: Application
    Filed: November 4, 2009
    Publication date: August 23, 2012
    Applicant: SYMED LABS LIMITED
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy, Buthukuri Venkat Reddy
  • Patent number: 8084606
    Abstract: The present invention relates to a novel and commercially viable process for substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine intermediate, 1-[(4-chlorophenyl)phenylmethyl]piperazine, thereby producing substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine and their pharmaceutical acceptable acid addition salts thereof in high purity and in high yield using novel intermediates.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: December 27, 2011
    Assignee: Symed Labs Limited
    Inventors: Dodda Mohan Rao, Bitra Satyanarayana Rao
  • Patent number: 7741480
    Abstract: The present invention provides a novel process for preparation of 5-aminomethyl substituted oxazolidinones, key intermediates for oxazolidinone antibacterials including linezolid. Thus linezolid is prepared by a) reacting 3-fluoro-4-morpholinyl aniline with R-epichlorohydrin; b) subjecting N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline produced above to carbonylation; c) reacting (5R)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone produced above with potassium phthalimide; d) reacting (S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide produced above with hydrazine hydrate; and e) reacting S-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine produced above with acetic anhydride to produce linezolid.
    Type: Grant
    Filed: October 8, 2007
    Date of Patent: June 22, 2010
    Assignee: Symed Labs Limited
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy
  • Patent number: 7732597
    Abstract: The present invention relates to a novel crystalline form of linezolid, to processes for its preparation and to a pharmaceutical composition containing it.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: June 8, 2010
    Assignee: Symed Labs Limited
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy
  • Patent number: 7718799
    Abstract: The present invention relates to a novel crystalline form of linezolid, to processes for its preparation and to a pharmaceutical composition containing it.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: May 18, 2010
    Assignee: Symed Labs Limited
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy
  • Patent number: 7718800
    Abstract: The present invention relates to a novel crystalline form of linezolid, to processes for its preparation and to a pharmaceutical composition containing it.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: May 18, 2010
    Assignee: Symed Labs Limited
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy
  • Patent number: 7714128
    Abstract: The present invention relates to a novel crystalline form of linezolid, to processes for its preparation and to a pharmaceutical composition containing it.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: May 11, 2010
    Assignee: Symed Labs Limited
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy
  • Publication number: 20090281318
    Abstract: The present invention relates to a novel and commercially viable process for substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine intermediate, 1-[(4-chlorophenyl)phenylmethyl]piperazine, thereby producing substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine and their pharmaceutical acceptable acid addition salts thereof in high purity and in high yield using novel intermediates.
    Type: Application
    Filed: June 15, 2007
    Publication date: November 12, 2009
    Applicant: SYMED LABS LIMITED
    Inventors: Dodda Mohan Rao, Bitra Satyanarayana Rao
  • Patent number: 7524954
    Abstract: The present invention provides a novel process for preparation of 5-aminomethyl substituted oxazolidinones, key intermediates for oxazolidinone antibacterials including linezolid. Thus linezolid is prepared by a) reacting 3-fluoro-4-morpholinyl aniline with R-epichlorohydrin; b) subjecting N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline produced above to carbonylation; c) reacting (5R)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone produced above with potassium phthalimide; d) reacting (S)—N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide produced above with hydrazine hydrate; and e) reacting S—N—[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine produced above with acetic anhydride to produce linezolid.
    Type: Grant
    Filed: October 8, 2007
    Date of Patent: April 28, 2009
    Assignee: Symed Labs Limited
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy
  • Patent number: 7429661
    Abstract: The present invention provides a novel process for preparation of 5 aminomethyl substituted oxazolidinones, key intermediates for oxazolidinone antibacterials including linezolid. Thus, the key intermediate of linezolid is prepared by a) reacting N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline with potassium phthalimide; b) subjecting N-[3-pthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholinyl) aniline produced in the above step to carbonylation; and c) reacting (S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidiriyl]methyl]phthalimide produced in the above step with hydrazine hydrate to produce (S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine.
    Type: Grant
    Filed: July 20, 2004
    Date of Patent: September 30, 2008
    Assignee: Symed Labs Limited
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy