Patents by Inventor Domingos J. Silva

Domingos J. Silva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy
    Patent number: 8058282
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: November 15, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos J. Silva, John J. Taggart
  • Peptide deformylase inhibitors
    Patent number: 7919528
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: April 5, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Kelly M. Aubart, Andrew B. Benowitz, Siegfried B. Christensen, IV, Joseph M. Karpinski, Jinhwa Lee, Domingos J. Silva
  • 2,4,8-TRISUBSTITUTED-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE COMPOUNDS AND COMPOSITIONS FOR USE IN THERAPY
    Publication number: 20110046109
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Application
    Filed: August 19, 2010
    Publication date: February 24, 2011
    Applicant: GLAXOSMITHKLINE LLC
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos J. Silva, John J. Taggart
  • Anthranilamide inhibitors of aurora kinase
    Patent number: 7884098
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: February 8, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H Faitg, Timothy Francis Gallagher, Neil W Johnson, Jiri Kasparec, Jeffrey M Ralph, Domingos J. Silva
  • NOVEL COMPOUNDS
    Publication number: 20110009625
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Application
    Filed: September 16, 2010
    Publication date: January 13, 2011
    Applicant: GLAXOSMITHKLINE LLC
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos J. Silva, John J. Taggart
  • QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS
    Publication number: 20100234386
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
    Type: Application
    Filed: May 8, 2008
    Publication date: September 16, 2010
    Inventors: Amita Chaudhari, Dashyant Dhanak, Carla Ann Donatelli, Thomas H. Faitg, Yanhong Feng, Steven David Knight, Cynthia A. Parrish, Jeffrey M. Ralph, Martha A. Sarpong, Domingos J. Silva
  • 2,4,5-Trisubstituted pyrimidine compounds
    Patent number: 7759486
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Grant
    Filed: August 16, 2007
    Date of Patent: July 20, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos J. Silva, John J. Taggart
  • ANTHRANILAMIDE INHIBITORS OF AURORA KINASE
    Publication number: 20100016318
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Application
    Filed: January 25, 2008
    Publication date: January 21, 2010
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H. Faitg, Timothy Francis Gallagher, Neil W. Johnson, Jiri Kasparec, Jeffrey M. Ralph, Domingos J. Silva
  • Quinoxaline derivatives as PI3 kinase inhibitors
    Patent number: 7592342
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: September 22, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Yanhong Feng, Cynthia A. Parrish, Martha A Sarpong, Domingos J Silva
  • NOVEL COMPOUNDS
    Publication number: 20090105478
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Application
    Filed: August 16, 2007
    Publication date: April 23, 2009
    Inventors: JERRY L. ADAMS, JEFFREY C. BOEHM, RALPH HALL, QI JIN, JIRI KASPAREC, DOMINGOS J. SILVA, JOHN J. TAGGART
  • Peptide deformylase inhibitors
    Patent number: 7507726
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: March 24, 2009
    Assignee: SmithKlineBeecham Corporation
    Inventors: Kelly M. Aubart, Andrew B. Benowitz, Siegfried B. Christensen, IV, Jinhwa Lee, Domingos J. Silva
  • Azaindole inhibitors of aurora kinases
    Patent number: 7495102
    Abstract: The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: February 24, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Martha A. Sarpong, Nicholas D. Adams, Jeffrey Michael Axten, Amita M. Chaudhari, Dashyant Dhanak, Toshihiro Hamajima, Kenneth Allen Newlander, Cynthia A. Parrish, Jerry Leroy Adams, Domingos J. Silva, Jun Tang
  • SUBSTITUTED PYRAZOLOPYRIMIDINES
    Publication number: 20090029989
    Abstract: Pyrazolo-pyrimidine derivatives are described herein. The described invention also includes methods of making such derivatives as well as methods of using the same in the treatment of diseases.
    Type: Application
    Filed: July 8, 2008
    Publication date: January 29, 2009
    Inventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva, Catherine C. K. Yuan
  • CHEMICAL COMPOUNDS
    Publication number: 20090012309
    Abstract: Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 8, 2009
    Inventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva
  • 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20080287466
    Abstract: Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Application
    Filed: July 9, 2008
    Publication date: November 20, 2008
    Inventors: Jerry Leroy Adams, Deborah Lynne Bryan, Yanhong Feng, Shinichiro Matsunaga, Yutaka Maeda, Yasushi Miyazaki, Masato Nakano, Jean-Philippe Rocher, Hideyuki Sato, Marcus Semones, Domingos J. Silva, Jun Tang
  • Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases
    Publication number: 20080242667
    Abstract: The present invention provides a compound represented by Formula (I): or a salt thereof, or a solvate thereof, or a combination thereof, wherein the substituents are as defined herein. The present invention also relates to a composition comprising the compound of formula (I) and diluents, carriers, or excipients. Furthermore, the present invention relates to a method of treating a disease of cell proliferation comprising administering to a patient in need thereof a pharmaceutically effective amount of the compound of formula (I) or a salt thereof, or a solvate thereof, or a combination thereof.
    Type: Application
    Filed: August 23, 2006
    Publication date: October 2, 2008
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Jeffrey M. Ralph, Domingos J. Silva
  • 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof
    Patent number: 7427623
    Abstract: Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: September 23, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Deborah Lynne Bryan, Yanhong Feng, Shinichiro Matsunaga, Yutaka Maeda, Yasushi Miyazaki, Masato Nakano, Jean-Philippe Rocher, Hideyuki Sato, Marcus Semones, Domingos J. Silva, Jun Tang
  • Peptide Deformylase Inhibitors
    Publication number: 20080167302
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: August 12, 2004
    Publication date: July 10, 2008
    Inventors: Kelly M. Aubart, Andrew B. Benowitz, Siegfried B. Christensen IV, Jinhwa Lee, Domingos J. Silva
  • 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds
    Patent number: 7323472
    Abstract: The present invention is directed to the novel use of a CSBP/p38 inhibitor for the treatment, including prophylaxis of inflammation enhanced cough in a mammal in need thereof.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: January 29, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos J. Silva, John J. Taggart
  • 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds
    Patent number: 7314881
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: January 1, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos J. Silva, John J. Taggart