Patents by Inventor Dominic Aiello
Dominic Aiello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210060566Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: November 11, 2020Publication date: March 4, 2021Applicant: GenMark Diagnostics, Inc.Inventors: Scott Corey, Brian Murphy, Eric Schneider, David Walter Wright, Dominic Aiello, Andrew Fish, Jay Srinivasan, George Maltezos
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Patent number: 10864522Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: GrantFiled: August 15, 2019Date of Patent: December 15, 2020Assignee: GenMark Diagnostics, Inc.Inventors: Scott Corey, Brian Murphy, Eric Schneider, David Walter Wright, Dominic Aiello, Andrew Fish, Jay Srinivasan, George Maltezos
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Patent number: 10807090Abstract: An apparatus configured for displacing fluid from a fluid container comprises first and second actuators configured to be movable together until the first actuator compresses a first part of the fluid container and then moveable independently until the second actuator compresses a second part of the fluid container. Fluid containers comprise a first vessel, a second vessel, and a sealing partition preventing fluid flow from the second vessel and further include a piercing point for piercing the sealing partition to permit fluid flow from the second vessel. A fluid container comprises a vessel configured to be collapsed to displace fluid from the vessel, a housing surrounding at least a portion of the vessel, and a floating compression plate movably disposed within the housing and configured to permit an external actuator to press the compression plate into the vessel to collapse the vessel and displace the fluid contents therefrom.Type: GrantFiled: August 3, 2016Date of Patent: October 20, 2020Assignee: GenMark Diagnostics, Inc.Inventors: David Walter Wright, Dominic Aiello
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Publication number: 20200156065Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: August 15, 2019Publication date: May 21, 2020Applicant: GenMark Diagnostics, Inc.Inventors: Scott Corey, Brian Murphy, Eric Schneider, David Walter Wright, Dominic Aiello, Andrew Fish, Jay Srinivasan, George Maltezos
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Patent number: 10391489Abstract: An apparatus for processing a fluid module, including a collapsible vessel supported on a planar substrate, comprises a first actuator component configured to be movable in a first direction is generally parallel to the plane of the substrate, a second actuator component configured to be movable in a second direction having a component that is normal to the plane of the substrate, and a motion conversion mechanism coupling the first actuator component with the second actuator component and configured to convert movement of the first actuator component in the first direction into movement of the second actuator component in the second direction.Type: GrantFiled: June 16, 2016Date of Patent: August 27, 2019Assignee: GenMark Diagnostics, Inc.Inventors: David Walter Wright, Dominic Aiello, Robert Clark
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Patent number: 10005080Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: GrantFiled: November 11, 2014Date of Patent: June 26, 2018Assignees: GENMARK DIAGNOSTICS, INC., ADVANCED LIQUID LOGIC, INC.Inventors: Jon Faiz Kayyem, Sean Ford, Vamsee K. Pamula, Vijay Srinivasan, Scott Corey, Brian Murphy, David Walter Wright, Dominic Aiello
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Publication number: 20180161769Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: January 24, 2018Publication date: June 14, 2018Applicant: GENMARK DIAGNOSTICS, INC.Inventors: Jon Faiz KAYYEM, SEAN FORD, VAMSEE K. PAMULA, VIJAY SRINIVASAN, SCOTT COREY, BRIAN MURPHY, DAVID WALTER WRIGHT, DOMINIC AIELLO
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Patent number: 9598722Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: GrantFiled: November 11, 2014Date of Patent: March 21, 2017Assignee: GENMARK DIAGNOSTICS, INC.Inventors: David Walter Wright, Dominic Aiello, Peter Kroehl, Jon Faiz Kayyem, Darren Scott Gray
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Publication number: 20170036210Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: October 20, 2016Publication date: February 9, 2017Applicant: GENMARK DIAGNOSTICS, INC.Inventors: SCOTT COREY, BRIAN MURPHY, ERIC SCHNEIDER, DAVID WALTER WRIGHT, DOMINIC AIELLO, ANDREW FISH, JAY SRINIVASAN, GEORGE MALTEZOS
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Publication number: 20170036207Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: October 20, 2016Publication date: February 9, 2017Applicant: GENMARK DIAGNOSTICS, INC.Inventors: DAVID WALTER WRIGHT, DOMINIC AIELLO, PETER KROEHL, JON FAIZ KAYYEM, DARREN SCOTT GRAY
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Publication number: 20160339426Abstract: An apparatus configured for displacing fluid from a fluid container comprises first and second actuators configured to be movable together until the first actuator compresses a first part of the fluid container and then moveable independently until the second actuator compresses a second part of the fluid container. Fluid containers comprise a first vessel, a second vessel, and a sealing partition preventing fluid flow from the second vessel and further include piercing means for piercing the sealing partition to permit fluid flow from the second vessel. A fluid container comprises a vessel configured to be collapsed to displace fluid from the vessel, a housing surrounding at least a portion of the vessel, and a floating compression plate movably disposed within the housing and configured to permit an external actuator to press the compression plate into the vessel to collapse the vessel and displace the fluid contents therefrom.Type: ApplicationFiled: August 3, 2016Publication date: November 24, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventors: DAVID WALTER WRIGHT, DOMINIC AIELLO
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Patent number: 9498778Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: GrantFiled: November 11, 2014Date of Patent: November 22, 2016Assignee: GENMARK DIAGNOSTICS, INC.Inventors: Scott Corey, Brian Murphy, Eric Schneider, David Walter Wright, Dominic Aiello, Andrew Fish, Jay Srinivasan, George Maltezos
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Publication number: 20160297570Abstract: An apparatus for processing a fluid module, including a collapsible vessel supported on a planar substrate, comprises a first actuator component configured to be movable in a first direction is generally parallel to the plane of the substrate, a second actuator component configured to be movable in a second direction having a component that is normal to the plane of the substrate, and a motion conversion mechanism coupling the first actuator component with the second actuator component and configured to convert movement of the first actuator component in the first direction into movement of the second actuator component in the second direction.Type: ApplicationFiled: June 16, 2016Publication date: October 13, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventors: David Walter WRIGHT, Dominic AIELLO, Robert CLARK
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Patent number: 9453613Abstract: An apparatus configured for displacing fluid from a fluid container comprises first and second actuators configured to be movable together until the first actuator compresses a first part of the fluid container and then moveable independently until the second actuator compresses a second part of the fluid container. Fluid containers comprise a first vessel, a second vessel, and a sealing partition preventing fluid flow from the second vessel and further include piercing means for piercing the sealing partition to permit fluid flow from the second vessel. A fluid container comprises a vessel configured to be collapsed to displace fluid from the vessel, a housing surrounding at least a portion of the vessel, and a floating compression plate movably disposed within the housing and configured to permit an external actuator to press the compression plate into the vessel to collapse the vessel and displace the fluid contents therefrom.Type: GrantFiled: March 12, 2014Date of Patent: September 27, 2016Assignee: GENMARK DIAGNOSTICS, INC.Inventors: David Walter Wright, Dominic Aiello
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Patent number: 9410663Abstract: An apparatus for processing a fluid module, including a collapsible vessel supported on a planar substrate, comprises a first actuator component configured to be movable in a first direction is generally parallel to the plane of the substrate, a second actuator component configured to be movable in a second direction having a component that is normal to the plane of the substrate, and a motion conversion mechanism coupling the first actuator component with the second actuator component and configured to convert movement of the first actuator component in the first direction into movement of the second actuator component in the second direction.Type: GrantFiled: March 12, 2014Date of Patent: August 9, 2016Assignee: GENMARK DIAGNOSTICS, INC.Inventors: David Walter Wright, Dominic Aiello, Robert Clark
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Publication number: 20160158743Abstract: A fluid container comprises a first vessel, a second vessel connected or connectable to the first vessel, and a sealing partition preventing fluid flow from the second vessel.Type: ApplicationFiled: November 23, 2015Publication date: June 9, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventors: DAVID WALTER WRIGHT, DOMINIC AIELLO
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Publication number: 20160130640Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: November 11, 2014Publication date: May 12, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventors: DAVID WALTER WRIGHT, DOMINIC AIELLO, PETER KROEHL, JON FAIZ KAYYEM, DARREN SCOTT GRAY
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Publication number: 20160129445Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: November 11, 2014Publication date: May 12, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventors: SCOTT COREY, BRIAN MURPHY, ERIC SCHNEIDER, DAVID WALTER WRIGHT, DOMINIC AIELLO, ANDREW FISH, JAY SRINIVASAN, GEORGE MALTEZOS
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Publication number: 20160129437Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: November 11, 2014Publication date: May 12, 2016Applicants: ADVANCED LIQUID LOGIC, INC., GENMARK DIAGNOSTICS, INC.Inventors: JON FAIZ KAYYEM, SEAN FORD, VAMSEE K. PAMULA, VIJAY SRINIVASAN, SCOTT COREY, BRIAN MURPHY, DAVID WALTER WRIGHT, DOMINIC AIELLO
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Patent number: D881409Type: GrantFiled: October 27, 2017Date of Patent: April 14, 2020Assignee: GenMark Diagnostics, Inc.Inventors: Jon Faiz Kayyem, Tyler David Jensen, Bradford Frederick Tieman, Darren S Gray, Sean Ford, Dominic Aiello, Peter Kroehl