Patents by Inventor Donald A. Tomalia
Donald A. Tomalia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6312679Abstract: Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.Type: GrantFiled: March 24, 1993Date of Patent: November 6, 2001Assignee: The Dow Chemical CompanyInventors: Donald A. Tomalia, Donald A. Kaplan, William J. Kruper, Jr., Roberta C. Cheng, Ian A. Tomlinson, Michael J. Fazio, David M. Hedstrand, Larry R. Wilson
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Publication number: 20010011109Abstract: In the present invention, an inorganic reactant is, or reactants are, localized with respect to a dendritic polymer by physical constraint within or by a non-covalent conjugation to the dendritic polymer. The localized inorganic reactant or reactants is/are subsequently transformed to form a reaction product which is immobilized with respect to the dendritic polymer. This immobilization occurs on a nanoscopic scale as a consequence of the combined effects of structural, chemical and physical changes without having covalent bonds between the product(s) and the dendritic container and results in new compositions of matter called dendritic nanocomposites. The resulting nanocomposite material can be used to produce revolutionary products such as water soluble elemental metals, with specific applications including magnetic resonance imaging, catalytic, magnetic, optical, photolytic and electroactive applications.Type: ApplicationFiled: September 5, 1997Publication date: August 2, 2001Inventors: DONALD A. TOMALIA, LAJOS BALOGH
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Patent number: 6224898Abstract: An antimicrobial agent which is a composite composition of matter comprising a metal or metal-containing compound distributed on or in a dendritic polymer, and a method of treating wounds comprising applying to the wounds said antimicrobial agent. In a most preferred embodiment, said antimicrobial agent comprises discrete nanosized silver or silver containing compounds distributed on or in dendritic polymers.Type: GrantFiled: March 23, 2000Date of Patent: May 1, 2001Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Lajos Balogh, Gary L. Hagnauer, Donald A. Tomalia, Albert T. McManus
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Patent number: 6177414Abstract: Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.Type: GrantFiled: March 8, 2000Date of Patent: January 23, 2001Assignee: The Dow Chemical CompanyInventors: Donald A. Tomalia, William J. Kruper, Roberta C. Cheng, Ian A. Tomlinson, Michael J. Fazio, David M. Hedstrand, Larry R. Wilson, Donald A. Kaplan
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Patent number: 6126035Abstract: A molded plastic beverage cup comprising a generally cylindrical body portion, a rim and a handle, and a method of forming the cup. The body portion has an open upper end, and the rim extends radially outwardly from the perimeter of the open end of the body portion. The handle is formed as an integral part of the cup. The handle extends outwardly from substantially diametrically opposed portions of the rim and then along the rim on one side of the cup between the diametrically opposed portions. The end portions of the handle extend from the rim, and are sufficiently flexible to allow the handle to be bent upwardly from the rim so that the handle arches diametrically across the upper end of the cup. The entire cup is thermoformed from a single sheet of plastic.Type: GrantFiled: October 21, 1999Date of Patent: October 3, 2000Assignee: Packaging Resources IncorporatedInventors: Eric B. Schaper, Jeffrey E. Parker, Donald A. Tomalia, Jr., Joseph S. Trombley
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Patent number: 6043336Abstract: An electrically conductive polymer is comprised of the reaction product of a dendrimer and an electrophoric compound which exhibits .pi.-stacking upon reduction. The reaction product which is a peripherally modified dendrimer is formed and reduced, either chemically or electrochemically, in a polar solvent. The reduced electrophoric moieties aggregate (form .pi.-stacks) to form electrically conductive pathways. The reduced peripherally modified dendrimers of the invention can be cast into films and other solid forms to provide flexible electrical conductors and semiconductors. The conductive polymers of the invention exhibit electrical conductivities comparable to that of doped polyacetalene, but are oxygen and moisture stable.Type: GrantFiled: January 26, 1998Date of Patent: March 28, 2000Assignee: Dendritech, Inc.Inventors: Larry L. Miller, Donald A. Tomalia, Robert G. Duan
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Patent number: 6020457Abstract: Dendritic polymers containing disulfide functional groups which are essentially inert under non-reducing conditions, but which form sulfhydryl groups upon being subjected to a reducing agent are prepared by synthesizing dendritic polymers having a core with a disulfide linkage or by reacting a dendritic polymer with a molecule containing a disulfide linkage and reactive terminal groups. In one aspect of the invention, dendritic polymers having a single disulfide functional group at the core are provided. The single disulfide group at the core can be reduced to form two sulfhydryl groups to which other molecules, such as proteins, oligonucleotides, peptides, hormones, other dendritic polymers, non-dendritic polymers, etc., can be bound.Type: GrantFiled: September 30, 1997Date of Patent: February 1, 2000Assignee: Dendritech Inc.Inventors: June W. Klimash, Herbert M. Brothers, II, Douglas R. Swanson, Rui Yin, Ralph Spindler, Donald A. Tomalia, Yong Hsu, Roberta C. Cheng
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Patent number: 5919442Abstract: A novel class of hyper comb-branched polymers conjugated with carried materials are disclosed.Type: GrantFiled: August 9, 1996Date of Patent: July 6, 1999Assignees: Dendritech, Inc., University of MichiganInventors: Rui Yin, Donald A. Tomalia, David M. Hedstrand, Douglas R. Swanson, James R. Baker, Jr., Jolanta F. Kukowska-Latallo
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Patent number: 5773527Abstract: This invention discloses non-crosslinked, poly-branched polymers having a comb-burst configuration and a process for preparing such polymers.Type: GrantFiled: January 20, 1995Date of Patent: June 30, 1998Assignee: Dendritech, Inc.Inventors: Donald A. Tomalia, David M. Hedstrand, Rui Yin
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Patent number: 5731095Abstract: A water-soluble or water-dispersible fluorine-containing dendritic polymer surfactant having at least one terminal fluorocarbon moiety and at least one terminal anionic moiety, and which is suitable for use in preparing protective coating compositions is disclosed. The water-soluble or water-dispersible fluorine-containing dendritic polymer surfactants are represented by the general formula: ##STR1## where D represents a dendritic polymer, R.sub.F represents a fluorocarbon containing moiety, A.sup.- represents an anionic containing moiety, C.sup.+ represents a cation, T represents a terminal group of the dendritic polymer which has not been functionalized with a fluorocarbon or anionic moiety, n and m are at least each at least one, and the sum of n+m+q is the total number of terminal groups on the dendritic polymer. Also disclosed is a coating composition capable of forming a highly crosslinked, non-stick, protective coating.Type: GrantFiled: October 23, 1996Date of Patent: March 24, 1998Assignee: Oxazogen, Inc.Inventors: Larry A. Milco, Donald A. Tomalia
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Patent number: 5714166Abstract: Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present then the carried material may be a bioactive agent. Preferred dendritic polymers are dense star polymers, which have been complexed with biological response modifiers. These conjugates and complexes have particularly advantageous properties due to their unique characteristics.Type: GrantFiled: March 7, 1995Date of Patent: February 3, 1998Assignees: The Dow Chemical Company, Dendritech Incorporated, The Regents of the University of MichiganInventors: Donald A. Tomalia, James R. Baker, Roberta C. Cheng, Anna U. Bielinska, Michael J. Fazio, David M. Hedstrand, Jennifer A. Johnson, Donald A. Kaplan, deceased, Scott L. Klakamp, William J. Kruper, Jr., Jolanta Kukowska-Latallo, Bartley D. Maxon, Lars T. Piehler, Ian A. Tomlinson, Larry R. Wilson, Rui Yin, Herbert M. Brothers, II
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Patent number: 5705573Abstract: A novel process for preparing poly(2-isopropenyl-2-oxazoline or oxazine) and its methyl methacrylate copolymer, which are useful as water borne curing agents, particularly in the non-stick coating industry. The process converts commercially available poly(methyl methacrylate) into poly(2-isopropenyl-2-oxazoline or oxazine) polymers or copolymers with methyl methacrylate, while circumventing the use of the highly toxic monomer, 2-isopropenyl-2-oxazoline or oxazine. The process involves converting a poly(methacrylic ester) to the corresponding poly(.beta.-hydroxy-N-ethyl or propyl methacrylamide) and activating the ring-forming .beta.-hydroxy-N-ethyl or propyl methacrylamide moiety to form an oxazoline or oxazine ring.Type: GrantFiled: September 5, 1996Date of Patent: January 6, 1998Assignee: Michigan Molecular InstituteInventors: Douglas R. Swanson, Donald A. Tomalia
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Patent number: 5631329Abstract: The specification discloses a process for producing poly-branched polymer having relatively high molecular weight by forming a first set of branches by polymerizing monomers which are either protected against or are non-reactive to branching and grafting during polymerization, grafting that first set of branches to a core having a plurality of reactive sites capable of reacting with the reactive end units of said branches, either deprotecting or activating a plurality of monomeric units on each of said branches to create branch reactive sites, forming a second set of branches in the same manner as the first set of branches were formed, grafting the second set of branches to the first set of branches by reacting the reactive end units of the second set of branches with each said branch reactive site on said first set of branches and repeating the foregoing steps reiteratively to form and attach subsequent sets of branches to prior branch sets until a desired number of iterations has been effected.Type: GrantFiled: March 21, 1995Date of Patent: May 20, 1997Assignee: Dendritech, Inc.Inventors: Rui Yin, Donald A. Tomalia, David M. Hedstrand, Douglas R. Swanson
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Patent number: 5560929Abstract: Dense star polymers or dendrimers having a highly branched interior structure capable of associating or chelating with metal ions are modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell. The modified dendrimers are useful for dispersing metal ions in a non-aqueous polymer matrix. Also dense star polymers or dendrimers having a highly branched hydrophilic interior structure are modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell, which modified polymers are useful as gels and surfactants.Type: GrantFiled: November 12, 1993Date of Patent: October 1, 1996Assignee: The Dow Chemical CompanyInventors: David M. Hedstrand, Bradley J. Helmer, Donald A. Tomalia
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Patent number: 5527524Abstract: Dense star polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.Type: GrantFiled: April 5, 1993Date of Patent: June 18, 1996Assignee: The Dow Chemical CompanyInventors: Donald A. Tomalia, Larry R. Wilson, David M. Hedstrand, Ian A. Tomlinson, Michael J. Fazio, William J. Kruper, Jr., Donald A. Kaplan, Roberta C. Cheng, David S. Edwards, Chu W. Jung
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Patent number: 5393795Abstract: Dense star polymers or dendrimers, modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell, act as molecular nucleating agents in forming a polymer blend.Type: GrantFiled: June 13, 1994Date of Patent: February 28, 1995Assignee: The Dow Chemical CompanyInventors: David M. Hedstrand, Donald A. Tomalia
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Patent number: 5393797Abstract: A small cell foam having a modified dense star polymer or dendrimer is described. This modified dense star polymer or dendrimer has a highly branched interior of one monomeric composition and an exterior structure of a different monomeric composition capable of providing a hydrophobic outer shell and a particle diameter of from about 5 to about 1,000 nm with a matrix polymer.Type: GrantFiled: June 13, 1994Date of Patent: February 28, 1995Assignee: The Dow Chemical CompanyInventors: David M. Hedstrand, Donald A. Tomalia
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Patent number: 5387617Abstract: Dense star polymers or dendrimers, modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell, act as molecular nucleating agents. These modified dense star polymers or dendrimers are particularly effective for the production of small cell foams.Type: GrantFiled: November 8, 1993Date of Patent: February 7, 1995Assignee: The Dow Chemical CompanyInventors: David M. Hedstrand, Donald A. Tomalia
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Patent number: 5338532Abstract: Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.Type: GrantFiled: February 13, 1991Date of Patent: August 16, 1994Assignee: The Dow Chemical CompanyInventors: Donald A. Tomalia, Donald A. Kaplan, William J. Kruper, Jr., Roberta C. Cheng, Ian A. Tomlinson, Michael J. Fazio, David M. Hedstrand, Larry R. Wilson
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Patent number: D431413Type: GrantFiled: December 27, 1999Date of Patent: October 3, 2000Assignee: Packaging Resources IncorporatedInventors: Eric B. Schaper, Jeffrey E. Parker, Donald A. Tomalia, Jr., Joseph S. Trombley