Patents by Inventor Donald A. Tomalia

Donald A. Tomalia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6312679
    Abstract: Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
    Type: Grant
    Filed: March 24, 1993
    Date of Patent: November 6, 2001
    Assignee: The Dow Chemical Company
    Inventors: Donald A. Tomalia, Donald A. Kaplan, William J. Kruper, Jr., Roberta C. Cheng, Ian A. Tomlinson, Michael J. Fazio, David M. Hedstrand, Larry R. Wilson
  • Publication number: 20010011109
    Abstract: In the present invention, an inorganic reactant is, or reactants are, localized with respect to a dendritic polymer by physical constraint within or by a non-covalent conjugation to the dendritic polymer. The localized inorganic reactant or reactants is/are subsequently transformed to form a reaction product which is immobilized with respect to the dendritic polymer. This immobilization occurs on a nanoscopic scale as a consequence of the combined effects of structural, chemical and physical changes without having covalent bonds between the product(s) and the dendritic container and results in new compositions of matter called dendritic nanocomposites. The resulting nanocomposite material can be used to produce revolutionary products such as water soluble elemental metals, with specific applications including magnetic resonance imaging, catalytic, magnetic, optical, photolytic and electroactive applications.
    Type: Application
    Filed: September 5, 1997
    Publication date: August 2, 2001
    Inventors: DONALD A. TOMALIA, LAJOS BALOGH
  • Patent number: 6224898
    Abstract: An antimicrobial agent which is a composite composition of matter comprising a metal or metal-containing compound distributed on or in a dendritic polymer, and a method of treating wounds comprising applying to the wounds said antimicrobial agent. In a most preferred embodiment, said antimicrobial agent comprises discrete nanosized silver or silver containing compounds distributed on or in dendritic polymers.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: May 1, 2001
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Lajos Balogh, Gary L. Hagnauer, Donald A. Tomalia, Albert T. McManus
  • Patent number: 6177414
    Abstract: Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: January 23, 2001
    Assignee: The Dow Chemical Company
    Inventors: Donald A. Tomalia, William J. Kruper, Roberta C. Cheng, Ian A. Tomlinson, Michael J. Fazio, David M. Hedstrand, Larry R. Wilson, Donald A. Kaplan
  • Patent number: 6126035
    Abstract: A molded plastic beverage cup comprising a generally cylindrical body portion, a rim and a handle, and a method of forming the cup. The body portion has an open upper end, and the rim extends radially outwardly from the perimeter of the open end of the body portion. The handle is formed as an integral part of the cup. The handle extends outwardly from substantially diametrically opposed portions of the rim and then along the rim on one side of the cup between the diametrically opposed portions. The end portions of the handle extend from the rim, and are sufficiently flexible to allow the handle to be bent upwardly from the rim so that the handle arches diametrically across the upper end of the cup. The entire cup is thermoformed from a single sheet of plastic.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: October 3, 2000
    Assignee: Packaging Resources Incorporated
    Inventors: Eric B. Schaper, Jeffrey E. Parker, Donald A. Tomalia, Jr., Joseph S. Trombley
  • Patent number: 6043336
    Abstract: An electrically conductive polymer is comprised of the reaction product of a dendrimer and an electrophoric compound which exhibits .pi.-stacking upon reduction. The reaction product which is a peripherally modified dendrimer is formed and reduced, either chemically or electrochemically, in a polar solvent. The reduced electrophoric moieties aggregate (form .pi.-stacks) to form electrically conductive pathways. The reduced peripherally modified dendrimers of the invention can be cast into films and other solid forms to provide flexible electrical conductors and semiconductors. The conductive polymers of the invention exhibit electrical conductivities comparable to that of doped polyacetalene, but are oxygen and moisture stable.
    Type: Grant
    Filed: January 26, 1998
    Date of Patent: March 28, 2000
    Assignee: Dendritech, Inc.
    Inventors: Larry L. Miller, Donald A. Tomalia, Robert G. Duan
  • Patent number: 6020457
    Abstract: Dendritic polymers containing disulfide functional groups which are essentially inert under non-reducing conditions, but which form sulfhydryl groups upon being subjected to a reducing agent are prepared by synthesizing dendritic polymers having a core with a disulfide linkage or by reacting a dendritic polymer with a molecule containing a disulfide linkage and reactive terminal groups. In one aspect of the invention, dendritic polymers having a single disulfide functional group at the core are provided. The single disulfide group at the core can be reduced to form two sulfhydryl groups to which other molecules, such as proteins, oligonucleotides, peptides, hormones, other dendritic polymers, non-dendritic polymers, etc., can be bound.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: February 1, 2000
    Assignee: Dendritech Inc.
    Inventors: June W. Klimash, Herbert M. Brothers, II, Douglas R. Swanson, Rui Yin, Ralph Spindler, Donald A. Tomalia, Yong Hsu, Roberta C. Cheng
  • Patent number: 5919442
    Abstract: A novel class of hyper comb-branched polymers conjugated with carried materials are disclosed.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: July 6, 1999
    Assignees: Dendritech, Inc., University of Michigan
    Inventors: Rui Yin, Donald A. Tomalia, David M. Hedstrand, Douglas R. Swanson, James R. Baker, Jr., Jolanta F. Kukowska-Latallo
  • Patent number: 5773527
    Abstract: This invention discloses non-crosslinked, poly-branched polymers having a comb-burst configuration and a process for preparing such polymers.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: June 30, 1998
    Assignee: Dendritech, Inc.
    Inventors: Donald A. Tomalia, David M. Hedstrand, Rui Yin
  • Patent number: 5731095
    Abstract: A water-soluble or water-dispersible fluorine-containing dendritic polymer surfactant having at least one terminal fluorocarbon moiety and at least one terminal anionic moiety, and which is suitable for use in preparing protective coating compositions is disclosed. The water-soluble or water-dispersible fluorine-containing dendritic polymer surfactants are represented by the general formula: ##STR1## where D represents a dendritic polymer, R.sub.F represents a fluorocarbon containing moiety, A.sup.- represents an anionic containing moiety, C.sup.+ represents a cation, T represents a terminal group of the dendritic polymer which has not been functionalized with a fluorocarbon or anionic moiety, n and m are at least each at least one, and the sum of n+m+q is the total number of terminal groups on the dendritic polymer. Also disclosed is a coating composition capable of forming a highly crosslinked, non-stick, protective coating.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: March 24, 1998
    Assignee: Oxazogen, Inc.
    Inventors: Larry A. Milco, Donald A. Tomalia
  • Patent number: 5714166
    Abstract: Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present then the carried material may be a bioactive agent. Preferred dendritic polymers are dense star polymers, which have been complexed with biological response modifiers. These conjugates and complexes have particularly advantageous properties due to their unique characteristics.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: February 3, 1998
    Assignees: The Dow Chemical Company, Dendritech Incorporated, The Regents of the University of Michigan
    Inventors: Donald A. Tomalia, James R. Baker, Roberta C. Cheng, Anna U. Bielinska, Michael J. Fazio, David M. Hedstrand, Jennifer A. Johnson, Donald A. Kaplan, deceased, Scott L. Klakamp, William J. Kruper, Jr., Jolanta Kukowska-Latallo, Bartley D. Maxon, Lars T. Piehler, Ian A. Tomlinson, Larry R. Wilson, Rui Yin, Herbert M. Brothers, II
  • Patent number: 5705573
    Abstract: A novel process for preparing poly(2-isopropenyl-2-oxazoline or oxazine) and its methyl methacrylate copolymer, which are useful as water borne curing agents, particularly in the non-stick coating industry. The process converts commercially available poly(methyl methacrylate) into poly(2-isopropenyl-2-oxazoline or oxazine) polymers or copolymers with methyl methacrylate, while circumventing the use of the highly toxic monomer, 2-isopropenyl-2-oxazoline or oxazine. The process involves converting a poly(methacrylic ester) to the corresponding poly(.beta.-hydroxy-N-ethyl or propyl methacrylamide) and activating the ring-forming .beta.-hydroxy-N-ethyl or propyl methacrylamide moiety to form an oxazoline or oxazine ring.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: January 6, 1998
    Assignee: Michigan Molecular Institute
    Inventors: Douglas R. Swanson, Donald A. Tomalia
  • Patent number: 5631329
    Abstract: The specification discloses a process for producing poly-branched polymer having relatively high molecular weight by forming a first set of branches by polymerizing monomers which are either protected against or are non-reactive to branching and grafting during polymerization, grafting that first set of branches to a core having a plurality of reactive sites capable of reacting with the reactive end units of said branches, either deprotecting or activating a plurality of monomeric units on each of said branches to create branch reactive sites, forming a second set of branches in the same manner as the first set of branches were formed, grafting the second set of branches to the first set of branches by reacting the reactive end units of the second set of branches with each said branch reactive site on said first set of branches and repeating the foregoing steps reiteratively to form and attach subsequent sets of branches to prior branch sets until a desired number of iterations has been effected.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: May 20, 1997
    Assignee: Dendritech, Inc.
    Inventors: Rui Yin, Donald A. Tomalia, David M. Hedstrand, Douglas R. Swanson
  • Patent number: 5560929
    Abstract: Dense star polymers or dendrimers having a highly branched interior structure capable of associating or chelating with metal ions are modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell. The modified dendrimers are useful for dispersing metal ions in a non-aqueous polymer matrix. Also dense star polymers or dendrimers having a highly branched hydrophilic interior structure are modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell, which modified polymers are useful as gels and surfactants.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: October 1, 1996
    Assignee: The Dow Chemical Company
    Inventors: David M. Hedstrand, Bradley J. Helmer, Donald A. Tomalia
  • Patent number: 5527524
    Abstract: Dense star polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
    Type: Grant
    Filed: April 5, 1993
    Date of Patent: June 18, 1996
    Assignee: The Dow Chemical Company
    Inventors: Donald A. Tomalia, Larry R. Wilson, David M. Hedstrand, Ian A. Tomlinson, Michael J. Fazio, William J. Kruper, Jr., Donald A. Kaplan, Roberta C. Cheng, David S. Edwards, Chu W. Jung
  • Patent number: 5393795
    Abstract: Dense star polymers or dendrimers, modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell, act as molecular nucleating agents in forming a polymer blend.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: February 28, 1995
    Assignee: The Dow Chemical Company
    Inventors: David M. Hedstrand, Donald A. Tomalia
  • Patent number: 5393797
    Abstract: A small cell foam having a modified dense star polymer or dendrimer is described. This modified dense star polymer or dendrimer has a highly branched interior of one monomeric composition and an exterior structure of a different monomeric composition capable of providing a hydrophobic outer shell and a particle diameter of from about 5 to about 1,000 nm with a matrix polymer.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: February 28, 1995
    Assignee: The Dow Chemical Company
    Inventors: David M. Hedstrand, Donald A. Tomalia
  • Patent number: 5387617
    Abstract: Dense star polymers or dendrimers, modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell, act as molecular nucleating agents. These modified dense star polymers or dendrimers are particularly effective for the production of small cell foams.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: February 7, 1995
    Assignee: The Dow Chemical Company
    Inventors: David M. Hedstrand, Donald A. Tomalia
  • Patent number: 5338532
    Abstract: Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
    Type: Grant
    Filed: February 13, 1991
    Date of Patent: August 16, 1994
    Assignee: The Dow Chemical Company
    Inventors: Donald A. Tomalia, Donald A. Kaplan, William J. Kruper, Jr., Roberta C. Cheng, Ian A. Tomlinson, Michael J. Fazio, David M. Hedstrand, Larry R. Wilson
  • Patent number: D431413
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: October 3, 2000
    Assignee: Packaging Resources Incorporated
    Inventors: Eric B. Schaper, Jeffrey E. Parker, Donald A. Tomalia, Jr., Joseph S. Trombley