Patents by Inventor Donald C. Manning

Donald C. Manning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PAIN AMELIORATION IN PATIENT POPULATION THAT SCORES HIGH ON THE PAIN CATASTROPHIZING SCALE
    Publication number: 20200405742
    Abstract: The present disclosure relates to method of treating or preventing pain in a patient having a high pain catastrophizing scale (PCS) score, comprising administering an oligonucleotide inhibitor of a transcription factor to said patient.
    Type: Application
    Filed: February 25, 2019
    Publication date: December 31, 2020
    Inventors: Donald C. MANNING, Scott HARRIS, Kimberly HEBERT, Dina GONZALEZ, Julien MAMET, William MARTIN, Rick ORR
  • Oligonucleotide decoys for the treatment of pain
    Patent number: 10683502
    Abstract: Provided are therapeutic agents such as double-stranded nucleic acids, termed oligonucleotide decoys, pharmaceutical compositions comprising the same, and related methods of modulating nociceptive signaling, for instance, to prevent and/or treat pain.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: June 16, 2020
    Assignee: ADYNXX SUB, INC.
    Inventors: Julien Mamet, Rick Orr, Donald C. Manning, Scott Harris, William Martin
  • COMPOSITIONS AND METHODS FOR PAIN AMELIORATION VIA MODIFICATION OF GENE EXPRESSION
    Publication number: 20200017853
    Abstract: The present disclosure relates to oligonucleotide decoys, pharmaceutical compositions thereof, and the use of such to modulate nociceptive signaling and to prevent and/or treat pain.
    Type: Application
    Filed: February 28, 2017
    Publication date: January 16, 2020
    Inventors: Donald C. Manning, Scott Harris, Kimberly Hebert, Dina Gonzalez, Julien Mamet, William Martin, Rick Orr
  • OLIGONUCLEOTIDE DECOYS FOR THE TREATMENT OF PAIN
    Publication number: 20190276825
    Abstract: Provided are therapeutic agents such as double-stranded nucleic acids, termed oligonucleotide decoys, pharmaceutical compositions comprising the same, and related methods of modulating nociceptive signaling, for instance, to prevent and/or treat pain.
    Type: Application
    Filed: March 19, 2019
    Publication date: September 12, 2019
    Inventors: Julien MAMET, Rick ORR, Donald C. MANNING, Scott HARRIS, William MARTIN
  • Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
    Patent number: 7612096
    Abstract: Methods of treating, preventing, modifying and managing various types of pain are disclosed. Specific methods comprise the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery, psychological or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
    Type: Grant
    Filed: April 23, 2004
    Date of Patent: November 3, 2009
    Assignee: Celgene Corporation
    Inventors: Jerome B. Zeldis, Herbert Faleck, Donald C. Manning
  • Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
    Publication number: 20040087642
    Abstract: The present invention relates to methods for treating, preventing, managing and/or modifying pain, comprising administering an effective amount of a JNK Inhibitor to a patient in need thereof. Specific embodiments encompass the administration of a JNK Inhibitor, alone or in combination with a second active agent and/or surgery or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
    Type: Application
    Filed: October 23, 2003
    Publication date: May 6, 2004
    Inventors: Jerome B. Zeldis, Herbert Faleck, Donald C. Manning
  • Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
    Publication number: 20040087558
    Abstract: Methods of treating, preventing, modifying and managing various types of pain are disclosed. Specific methods comprise the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery, psychological or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
    Type: Application
    Filed: October 23, 2003
    Publication date: May 6, 2004
    Inventors: Jerome B. Zeldis, Herbert Faleck, Donald C. Manning