Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate apertures of ultrasound arrays. Some embodiments provide systems and methods for designing, building and using ultrasound probes having continuous arrays of ultrasound transducers which may have a substantially continuous concave curved shape in two or three dimensions (i.e., concave relative to an object to be imaged). Other embodiments herein provide systems and methods for designing, building and using ultrasound imaging probes having other unique configurations, such as adjustable probes and probes with variable configurations.

Abstract: This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.

Abstract: A tube cleaning system and method including a nozzle holder operable to secure nozzles in a nozzle arrangement, the nozzle arrangement corresponding to an arrangement of tubes of a tube bundle, and a nozzle positioning system operable to move the nozzle holder and nozzles secured therein, to cause the nozzles to engage a set of tubes of the tubes of the tube bundle, the nozzles configured to direct cleaning fluid into the set of tubes.

Abstract: A method of full-field or “ping-based” Doppler ultrasound imaging allows for detection of Doppler signals indicating moving reflectors at any point in an imaging field without the need to predefine range gates. In various embodiments, such whole-field Doppler imaging methods may include transmitting a Doppler ping from a transmit aperture, receiving echoes of the Doppler ping with one or more separate receive apertures, detecting Doppler signals and determining the speed of moving reflectors. In some embodiments, the system also provides the ability to determine the direction of motion by solving a set of simultaneous equations based on echo data received by multiple receive apertures.

Abstract: A culture plate apparatus having circular culture wells arranged in a cluster includes a moat surrounding the cluster with a cover for enclosing the wells and the moat with a head space therebetween. When the moat is filled with water or buffer solution, the moat maintains temperature uniformity among the wells and maintains uniform humidity in the head space thereby preventing nonuniform evaporation from the wells while reducing evaporation overall.

Abstract: A downrigger line release device includes a clamp mounted to a fishing line, a coupler mounted to a downrigger line, and a swivel connector pivotally interconnecting the clamp and coupler to one another. The coupler includes a flexible retainer element convertable from a rolled-up condition in which it slidably receives the downrigger line to an unrolled condition in which it releases therefrom in response to a predetermined force being applied to the retainer element so as to permit uncoupling of the fishing line from the downrigger line.

Abstract: A downrigger weight assembly includes a casing having forward and rearward compartments and a middle compartment threadably and sealably attached at opposite ends to the forward and rearward compartments so as to tandemly arrange the respective compartments. The forward and rearward compartments have reversely tapered configurations and define respective front and rear hollow cavities. The middle compartment has a cylindrical configuration and defines a hollow central cavity. A cartridge for holding fish bait or attractant material is disposed in the front hollow cavity of the forward compartment. A weighted body is disposed in rear hollow cavity of the rearward compartment for providing ballast. A downrigger line release device includes a clamp mounted to a fishing line, a coupler mounted to a downrigger line, and a swivel connector pivotally interconnecting the clamp and coupler to one another.

Abstract: A receptacle for facilitating separating of recyclable trash includes a container body, flat panels for forming a plurality of adjustable-size separate compartments in the container body, and an upper lid hingedly mounted on the container body. A bag retaining arrangement is mounted on a top rim or an interior ledge spaced below the top rim of the container body. A can crusher module is removably mounted to opposing portions of the interior surface of an upper portion of the container body so as to overlie one of the separate compartments in the container body.

Abstract: A prefabricated wall insert unit is disclosed for rapid installation in a wall having an outer surface, an internal space, a ceiling plate, and a floor support. When installed, an exterior assembly, with upper and side perimeter attachment areas, projects away from the outer wall surface. A header is fastened to the exterior assembly proximate the upper perimeter attachment area and is within the wall internal space immediately below the ceiling plate. At least two side support members are fastened to the upper support member and to the exterior assembly proximate the side perimeter attachment areas. When installed in the wall, the header and each said side support member are within the wall internal space and each side support member extends from the header to proximate the wall floor support.

Abstract: A receptacle for facilitating separating of recyclable trash includes a container body, flat panels for forming a plurality of adjustable-size separate compartments in the container body, and a single-stage single-level lid hingedly mounted on the container body. Alternatively, the receptacle can have a two-stage bi-level lid and bag retainer assembly which includes a lower annular bag retainer member and an upper cover member. The lower bag retainer member is hinged and releasably matable to the container body for holding and securing an open top edge of trash bags on the container body. The upper cover member is hinged to the lower annular bag retainer member for opening and closing and can have slidable doors to permit access to the separate compartments in the container body and the trash bags held therein.

Abstract: A method of immunizing cats against shedding of Toxoplasma oocysts is described wherein cats are given a primary Toxoplasma infection, preferably by feeding of tissue cysts, and are chemoprophylactically treated to suppress oocyst shedding as a result of the primary infection. thus, the treated cats are given immunity to oocyst shedding without the necessity of initial shedding. The treating agent is preferably monensin given with the cats' daily ration at a level of at least about 200 mg. monensin per kg. of cat food. Other useful treating agents include salinomycin or a combination of orally administered sulfadiazine and pyrimethamine.

Abstract: A method of preventing, or at least substantially minimizing, shedding of Toxoplasma oocysts by cats is described which can be begun after infection of the cat and may serve to reduce the contamination with infectious oocysts of soils around areas of human habitation. The method involves administration, in effective amounts of a drug agent selected from the group consisting of monensin or salinomycin. The administration is preferably oral, and can be accomplished by mixing the drug with the cat's food or via a slow release dosage form. The drug treatment is normally commenced within about two days after infection, and is continued for a period of at least about two weeks.

Abstract: A fertilizer knife assembly is capable of being connected to an agricultural implement and is operative for flow of fertilizer into a furrow opened by the knife assembly. A wear point of cast chrome alloy iron has a leading portion and a shoe portion in engagement with and secured by welding to a leading edge and a free end respectively of an elongated shank capable of being connected to an agricultural implement. An elongated fertilizer tube is positioned adjacent a trailing edge of the shank and has one end portion thereof secured to a trailing end of the shoe portion of the wear point. An elongated shield is spaced from and surrounds an exterior surface of the fertilizer tube and has opposite side edges thereof secured to the shank trailing edge by hard facing welding in a manner to protect the fertilizer tube and define an air space surrounding the same.

Abstract: The control for electric sump pumps is operated by a pair of weights operatively attached to the control which has a sealed non-magnetic material housing having a downwardly open recess extending thereinto from its lower surface. A normally open microswitch having a spring control arm extending therefrom and movable downwardly to close the switch, while a permanent magnet is positioned on the arm directly above the recess, and a magnetic metal means is slidably positioned in the recess and operatively connects to the weights. The magnetic metal means attracts the permanent magnet when the metal means is at the upper portion of the recess and this closes the switch arm with the position of the metal means in the housing in relation to the magnet being controlled dependent upon the water level in the sump.