Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least section wise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: An additive manufacturing machine (34) comprising a build material spreading system (2). The spreading system (2) has a moveable spreader (4) with an exterior surface (8) to spread build material. The spreading system (2) also has a heater (10) located separate from the spreader (4). The heater (10) has a heat dissipater (20) extending around the spreader (4) to retain, between the dissipater (20) and the spreader (4), air (36) heated by the dissipater (20).

Abstract: The present invention relates to processes for processes for enzymatic refining of a pretreated cellulosic material for saccharification.

Abstract: The present invention relates to processes for processes for enzymatic refining of a pretreated cellulosic material for saccharification.

Abstract: Surprisingly, the present inventors have discovered that thermal denaturation of prion protein facilitates its detection by immunological methods. Accordingly, the present invention provides methods for the preparation and thermal denaturation of samples for prion detection, comprising: homogenizing a candidate sample and heating said sample in a buffer, preferably one with properties that aid stabilization of the denatured form of the protein. The methods described in this disclosure can be used in the detection of PrPSc. Such detection is useful for the diagnosis of transmissible spongiform encephalopathies. This method can be used with immunoassays of various formats, including, but not limited to, dot blot and western blot assays, which utilize polyclonal antibodies, monoclonal antibodies, antibody fragments, receptors, natural and synthetic ligands and other entities.