Abstract: The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

Abstract: A computer-implemented method, computer system, and computer program product for deleting a file from a storage medium. A file that is marked for automatic deletion is identified. A deletion time at which the file is to be deleted from the storage medium is identified. A visual indicator associated with the file is displayed. The visual indicator changes over time to provide an indication as to a nearness of the deletion time.

Abstract: A computer-implemented method, computer system, and computer program product for deleting a file from a storage medium. A file that is marked for automatic deletion is identified. A deletion time at which the file is to be deleted from the storage medium is identified. A visual indicator associated with the file is displayed. The visual indicator changes over time to provide an indication as to a nearness of the deletion time.

Abstract: A computer-implemented method, computer system, and computer program product for deleting a file from a storage medium. A file that is marked for automatic deletion is identified. A deletion time at which the file is to be deleted from the storage medium is identified. A visual indicator associated with the file is displayed. The visual indicator changes over time to provide an indication as to a nearness of the deletion time.

Abstract: Injection molds suitable for use in injection molding, structural foam molding, low-pressure injection molding, and gas-assisted injection molding of plastic articles are described. The injection molds contain a thin metal layer contoured on its outer surface to the shape of the article to be molded, a rigid thermoset plastic material cast upon the inner surface of the metal layer and supporting the metal layer, and heat transfer elements cast within the plastic material and located adjacent to the metal layer to transfer heat for the metal layer and the plastic material. Preferably the thin metal layer is nickel, the plastic material is epoxy, and the heat transfer elements are metal chips and heat transfer tubing. The injection molds of the present invention can be prepared at considerable cost and time savings relative to conventional injection molds.

Abstract: Injection molds suitable for use in injection molding, structural foam molding, low-pressure injection molding, and gas-assisted injection molding of plastic articles are described. The injection molds contain a thin metal layer contoured on its outer surface to the shape of the article to be molded, a rigid thermoset plastic material cast upon the inner surface of the metal layer and supporting the metal layer, and heat transfer elements cast within the plastic material and located adjacent to the metal layer to transfer heat for the metal layer and the plastic material. Preferably the thin metal layer is nickel, the plastic material is epoxy, and the heat transfer elements are metal chips and heat transfer tubing. The injection molds of the present invention can be prepared at considerable cost and time savings relative to conventional injection molds.