Abstract: The present invention relates to a samples delivering device, a method of manufacturing a samples applicator, a method of delivering samples, and a base activation device which can handle a plurality of various samples, efficiently and promptly. The invention is constructed so as to have: one or more sets of vessels capable of accommodating fluids containing predetermined samples to be delivered to a base or one or more sets of vessels, a samples supply section having a samples applicator, wherein two or more retention tips capable of retaining a small quantity of fluids by being dipped in each of the fluids accommodated in the vessels are arranged according to the vessels, and a transfer means for relatively moving between the base and the one or more sets of vessels, and the applicator.

Abstract: The present invention relates to a samples delivering device, a method of manufacturing a samples applicator, a method of delivering samples, and a base activation device which can handle a plurality of various samples, efficiently and promptly. The invention is constructed so as to have: one or more sets of vessels capable of accommodating fluids containing predetermined samples to be delivered to a base or one or more sets of vessels, a samples supply section having a samples applicator, wherein two or more retention tips capable of retaining a small quantity of fluids by being dipped in each of the fluids accommodated in the vessels are arranged according to the vessels, and a transfer means for relatively moving between the base and the one or more sets of vessels, and the applicator.

Abstract: A carrier for fixing a material containing an amino group, which has a shape to be wound on a spindle member, and on the surface of which the material can be immobilized via covalent bonding. The carrier has a shape to be wound on a spindle member, and has a carboxyl group or an amino group, or derivative groups thereof, formed by cleaving an amide bond in the main chain of a polyamide on its surface.

Abstract: A sensor for determining a property of each of a plurality of liquids includes a plurality of electromagnetic radiation sources, each source generating a beam of electromagnetic radiation. The sensor also includes an array of electromagnetic radiation detectors. Each detector in the array is responsive to detect part of the beam of electromagnetic radiation generated by each source for making a determination of a property of the part of the beam detected. The sensor further includes a surface plasmon resonance layer and a reflecting surface. The surface plasmon resonance layer has a first surface and a second surface. The first surface can have a plurality of liquids deposited thereon, and the second surface reflects at least part of the beam of electromagnetic radiation generated by each source. The reflecting surface reflects the electromagnetic radiation reflected from the surface plasmon resonance layer towards the array of detectors.

Abstract: An apparatus and method for high throughput surface plasmon resonance (SPR) sensor subarray comprising two or more SPR sensor subarrays (10) having a target layer on an SPR layer (22), wherein the SPR sensor subarrays (10) are exposed to a solution until a baseline measurement is attained, is disclosed. Once the SPR sensor subarrays (10) have attained baseline, the SPR sensor subarrays (10) are used to determine the interaction properties between said SPR sensor subarray and a test entity.

Abstract: A waveguide binding assay method involves detecting the scattering of light directed into the waveguide, the scattering being the result of scattering labels specifically bound to the waveguide within the penetration depth of an evanescent wave. The waveguide may be transparent plastic or glass and the binding is typically by oligonucleotide hybridization or immunological capture. Light scattering labels include colloidal metals or non-metals, including gold, selenium and latex. A light absorbing member consisting of dye or concentrated particles may also be employed to enhance signal. Real-time binding and dissociation can be monitored visually or by video imaging, such as with a CCD camera and frame grabber software. Hybridization mismatches of as few as one base can be distinguished by real-time melting curves.

Abstract: A method and apparatus for collecting a cell sample from a liquid specimen utilizes a collection receptacle in which the specimen is deposited, with a filter media being place in communication with a discharge port in the collection receptacle and a transfer device for drawing specimen from the collection receptacle and through the filter for capturing the cellular component of the specimen on the filter media for defining a cell sample for analysis. The collection receptacle, filter media and carrier therefor and the transfer device may be supplied in kit form for use in a clinical environment. A hypobaric vessel may be used and the transfer device and this vessel may also serve as a disposal receptacle for the liquid specimen passed through the filter media.

Abstract: A circuit measures the intensity of a monitored light beam by generating a signal which is of a specific time duration corresponding to light intensity. The circuit utilizes a photosensitive element for receiving the light and producing a variable control signal in direct correspondence to the light intensity. A capacitor network is placed in series with the photosensitive element, wherein the time duration for discharging the capacitor network is directly correlated to the intensity of the collected light.

Abstract: A process for surface modifying a variety of polymeric support surfaces is disclosed in which a predetermined modifying polymer is irreversibly absorbed onto essentially all the surfaces of the support polymer accessible to the modifying polymer. The modifying polymer is selected to impart the desired surface characteristics to the modified polymeric surface.

Abstract: A method and apparatus for the continuous separation of a target protein from a protein mixture containing two or more proteins and at a pH equal to the pI of the target protein is disclosed. The method and apparatus employ a non-ionic, non-electrically conductive porous conduit through which the protein mixture is passed. The conduit is subjected to the influence of an electrical field substantially perpendicular to the flow of fluid therethrough resulting in movement of all charged protein from the conduit lumen. The target protein, which is unaffected by the electric field since it is not charged at a pH equal to its pI, is collected from the conduit outlet in substantially purified form.

Abstract: A process for surface modifying a variety of polymeric support surfaces is disclosed in which a predetermined modifying polymer is irreversibly absorbed onto essentially all the surfaces of the support polymer accessible to the modifying polymer. The modifying polymer is selected to impart the desired surface characteristics to the modified polymeric surface.