Abstract: A low noise operation method for a camera system having an image sensing active pixel array, the method comprising the steps of: (a) providing an optical shutter in front of an image sensing pixel array of a camera system, said image sensing pixel array having an image sensing face defined by a series of active pixels arranged in rows and columns; (b) while said shutter is closed, resetting each said pixel and then reading a first output from each said pixel; (c) opening said optical shutter for a predetermined exposure period so as to allow light to be incident upon said image sensing face of said pixel array; (d) closing said optical shutter and then reading a second output from each said pixel, without resetting said pixels; and (e) subtracting one of said first and second outputs from the other of said first and second outputs for each said pixel, so as to obtain a first difference signal for each said pixel, which first difference signal is substantially free of reset and fixed offset noise components.