Patents by Inventor Donald P. Bottaro

Donald P. Bottaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vascular endothelial growth factor antagonists
    Patent number: 11434268
    Abstract: The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: September 6, 2022
    Assignee: The United States of America, as Represented by the Secretary, Dept. of Health and Human Services
    Inventors: Donald P. Bottaro, Fabiola Cecchi
  • VASCULAR ENDOTHELIAL GROWTH FACTOR ANTAGONISTS
    Publication number: 20190177382
    Abstract: The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.
    Type: Application
    Filed: July 31, 2018
    Publication date: June 13, 2019
    Inventors: Donald P. BOTTARO, Fabiola CECCHI
  • Vascular endothelial growth factor antagonists and methods of making
    Patent number: 10035833
    Abstract: The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: July 31, 2018
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Donald P. Bottaro, Fabiola Cecchi
  • VASCULAR ENDOTHELIAL GROWTH FACTOR ANTAGONISTS
    Publication number: 20170267735
    Abstract: The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.
    Type: Application
    Filed: January 20, 2017
    Publication date: September 21, 2017
    Inventors: Donald P. BOTTARO, Fabiola CECCHI
  • Methods for use of vascular endothelial growth factor antagonists
    Patent number: 9550818
    Abstract: The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: January 24, 2017
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Donald P. Bottaro, Fabiola Cecchi
  • VASCULAR ENDOTHELIAL GROWTH FACTOR ANTAGONISTS AND METHODS FOR THEIR USE
    Publication number: 20150126446
    Abstract: The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.
    Type: Application
    Filed: April 26, 2013
    Publication date: May 7, 2015
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health & Human Services
    Inventors: Donald P. Bottaro, Fabiola Cecchi
  • Compositions and methods for inhibition of hepatocyte growth factor receptor c-Met signaling
    Patent number: 8754081
    Abstract: Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: June 17, 2014
    Assignee: The United States of America as represented by the Secretary, Departmnet of Health and Human Services
    Inventors: Donald P. Bottaro, Megan Peach, Marc Nicklaus, Terrence Burke, Jr., Gagani Athauda, Sarah Choyke, Alessio Giubellino, Nelly Tan, Zhen-Dan Shi
  • Methods for diagnosing and monitoring the progression of cancer by measuring soluble c-Met ectodomain
    Patent number: 8617831
    Abstract: Methods for measuring c-Met levels in urine and blood samples are provided. Methods for diagnosis and prognosis evaluation for cancer are also provided.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: December 31, 2013
    Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, Amgen, Inc.
    Inventors: Donald P. Bottaro, Gagani P. Athauda, Teresa Lynn Burgess
  • Compositions and methods for inhibition of hepatocyte growth factor receptor c-Met signaling
    Patent number: 8569360
    Abstract: Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met obtained by virtual screening, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: October 29, 2013
    Inventors: Donald P. Bottaro, Megan Peach, Marc Nicklaus, Nelly Tan
  • METHODS FOR DIAGNOSING AND MONITORING THE PROGRESSION OF CANCER
    Publication number: 20130029352
    Abstract: Methods for measuring c-Met levels in urine and blood samples are provided. Methods for diagnosis and prognosis evaluation for cancer are also provided.
    Type: Application
    Filed: September 26, 2012
    Publication date: January 31, 2013
    Inventors: Donald P. Bottaro, Gagani P. Athauda, Teresa Lynn Burgess
  • Methods for diagnosing and monitoring the progression of cancer by measuring soluble c-Met ectodomain
    Patent number: 8304199
    Abstract: Methods for measuring c-Met levels in urine and blood samples are provided. Methods for diagnosis and prognosis evaluation for cancer are also provided.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: November 6, 2012
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Amgen, Inc.
    Inventors: Donald P. Bottaro, Gagani Athauda, Teresa Lynn Burgess
  • Methods For Diagnosing And Monitoring The Progression Of Cancer
    Publication number: 20110287450
    Abstract: Methods for measuring c-Met levels in urine and blood samples are provided. Methods for diagnosis and prognosis evaluation for cancer are also provided.
    Type: Application
    Filed: March 22, 2011
    Publication date: November 24, 2011
    Applicants: Amgen, Inc., The United States of America, as represented by the Secretary, Dept. of Health & Human Service
    Inventors: Donald P. Bottaro, Gagani Athauda, Teresa Lynn Burgess
  • COMPOSITIONS AND METHODS FOR INHIBITION OF HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET SIGNALING
    Publication number: 20110281907
    Abstract: Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met obtained by virtual screening, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.
    Type: Application
    Filed: March 31, 2009
    Publication date: November 17, 2011
    Applicant: The Government of the United States of America, as represented by the Secretary, Dept.of Health and.
    Inventors: Donald P. Bottaro, Megan Peach, Marc Nicklaus, Nelly Tan
  • COMPOSITIONS AND METHODS FOR INHIBITION OF HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET SIGNALING
    Publication number: 20110190295
    Abstract: Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.
    Type: Application
    Filed: March 31, 2009
    Publication date: August 4, 2011
    Applicant: The Govt of the U.S.A., as rep.by the Sec.Dept of Hlth. and Human Svcs., Natl Institutes of Health
    Inventors: Donald P. Bottaro, Megan Peach, Marc Nicklaus, Terrence Burke, JR., Gagani Athauda, Sarah Choyke, Alessio Giubellino, Nelly Tan, Zhen-Dan Shi
  • Methods for diagnosing and monitoring the progression of cancer
    Patent number: 7964365
    Abstract: Methods for measuring c-Met levels in urine and blood samples are provided. Methods for diagnosis and prognosis evaluation for cancer are also provided.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: June 21, 2011
    Assignees: The United States of Americam as represented by the Secretary, Department of Health and Human Services, Amgen, Inc.
    Inventors: Donald P. Bottaro, Gagani Athauda, Teresa Lynn Burgess
  • Inhibition of cell motility, angiogenesis, and metastasis
    Patent number: 7871981
    Abstract: Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. Also disclosed are methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer, for example, melanoma or prostate cancer, comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking blocks HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: January 18, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Donald P Bottaro, Alessio Giubellino, Safiye N Atabey, Jesus V Soriano, Diane E Breckenridge, Terrence R Burke, Jr.
  • Truncated hepatocyte growth factor variant protein HGF/NK2
    Patent number: 7605127
    Abstract: The present invention relates to a novel truncated form of heptocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: October 20, 2009
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Andrew M. L. Chan, Jeffrey S. Rubin, Donald P. Bottaro, Stuart A. Aaronson, Stephen J. Stahl, Paul T. Wingfield, Vittoria Cioce
  • Methods for Diagnosing and Monitoring the Progression of Cancer
    Publication number: 20080286825
    Abstract: Methods for measuring c-Met levels in urine and blood samples are provided. Methods for diagnosis and prognosis evaluation for cancer are also provided.
    Type: Application
    Filed: November 8, 2006
    Publication date: November 20, 2008
    Inventors: Donald P. Bottaro, Gagani P. Athauda, Teresa Lynn Burgess
  • Inhibition of cell motility and angiogenesis by inhibitors of Grb2-SH2-domain
    Patent number: 7132392
    Abstract: Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. The present invention further provides methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer comprising administering to a mammal of interest one or more peptides of the present invention.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: November 7, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Donald P. Bottaro, Safiye N. Atabey, Jesus V. Soriano, Diane E. Breckenridge, Zhu-Jun Yao, Yang Gao, Terrence R. Burke, Jr.
  • Truncated hepatocyte growth factor variants
    Publication number: 20030124671
    Abstract: The present invention relates to a novel truncated forms of hepatocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions.
    Type: Application
    Filed: October 30, 2002
    Publication date: July 3, 2003
    Inventors: Andrew M.L. Chan, Jeffrey S. Rubin, Donald P. Bottaro, Stuart A. Aaronson, Stephen J. Stahl, Paul T. Wingfield, Vittoria Cioce