Abstract: The present invention relates to a modular prosthetic conduit implantable within a mammal and a method of surgically implanting and replacing such a conduit. Specifically, the present invention is directed toward a conduit comprising a first conduit member composed of a biocompatible alloplast and coated on its exterior surface with a porous biocompatible tissue-bonding material. The present invention is further directed toward a second conduit member composed of a biocompatible alloplast. The second conduit member contains a region or component that can be expanded radially by mechanical, hydraulic, chemical, electrical, temperature sensitive or other physical means. The second component can be easily slid into or out of the first conduit member and at temperatures approaching a mammal's body temperature, it expands to form a watertight "docking" fit within the first conduit member. The second conduit member may contain remotely actuable valve and pump.

Abstract: An intravesical method of treating dysfunctional bladder syndromes by Electromotive Drug Administration (EMDA) of local anaesthetic drugs, anti muscarinic drugs and sympathomimetic agents. The administration of said drugs combined with hydraulic bladder dilatation causes relaxation of the detrusor muscle, reversing the hypertonicity associated with dysfunctional bladder syndromes.

Abstract: The present invention relates to a tissue bondable cystostomy tube for use in a human patient. The present invention also relates to a method for surgically implanting the tissue bondable cystostomy tube in a human patient.

Abstract: The present invention relates to a tissue bondable cystostomy tube for use in a human patient. The present invention also relates to a method for surgically implanting the tissue bondable cystostomy tube in a human patient.

Abstract: The present invention relates to a tissue bondable cystostomy tube for use in a human patient. The present invention also relates to a method for surgically implanting the tissue bondable cystostomy tube in a human patient.

Abstract: The present invention relates to a fixed volume prosthetic urinary bladder for use in a human being. The invention, more particularly, concerns a prosthetic urinary bladder comprising a vent channel having a removable cap and a urethral discharge valve. The present invention is intended for implantation in a human being such that the vent channel protrudes through the abdominal wall and the vent cap lies flush with the outer surface of the abdomen.

Abstract: The biochemical quality and characteristics of urine can be preserved by utilizing a combination of acetohydroxamic acid and benzyl (dodecyl carbamylmethyl) dimethyl ammonium chloride.

Abstract: A method for the treatment of urinary tract infections and a composition for use in such method, such method comprising administering to a patient suffering from a urinary tract infection an effective anti-bacterial dosage of a composition comprising in combination:A. a source of methenamine, e.g. methenamine; andB. a source of hydroxamate groups, e.g., acetohydroxamic acid.The source of hydroxamate groups is administered in the amount effective to potentiate the anti-bacterial effect of the source of methenamine. The method is specifically applied to the treatment of urinary infections caused by urease producing bacteria, especially bacteria of the species Proteus.In addition, where colonization of the bacteria can be tolerated and where it is only necessary to eliminate the pathogenicity of the urease producing bacteria induced infection, effective treatment can be achieved by administration of only the source of hydroxamate groups, preferably acetohydroxamic acid.

Abstract: A urine collection device is disclosed for use in metabolic studies in which an integrated specimen is desired. The collection device has a receptacle divided into bin sections. A removable manifold cover adapted to fit onto the receptable portion has openings which are arranged to be in registration with a separate one of the bin sections. Urine poured into the manifold will be metered through the openings into the bin sections, with a substantially equal amount entering each. Each bin contains a different chemical substance for preserving some characteristic of the urine. For example, in one bin the urine may be acidified by the substance; in another it may be alkalized; and in another it may have the pH stabilized. The device permits urine samples of a patient to be collected over a period of time, and away from a clinic or hospital without the urine characteristics to be tested changing.

Abstract: A method for the treatment of urinary tract infections and a composition for use in such method, such method comprising administering to a patient suffering from a urinary tract infection an effective anti-bacterial dosage of a composition comprising in combination:A. a source of methenamine, e.g. methenamine; andB. a source of hydroxamate groups, e.g., acetohydroxamic acid.The source of hydroxamate groups is administered in the amount effective to potentiate the anti-bacterial effect of the source of methenamine. The method is specifically applied to the treatment of urinary infections caused by urease producing bacteria, especially bacteria of the species proteus.In addition, where colonization of the bacteria can be tolerated and where it is only necessary to eliminate the pathogenicity of the urease producing bacteria induced infection, effective treatment can be achieved by administration of only the source of hydroxamate groups, preferably acetohydroxamic acid.