Patents by Inventor Donald R. Gauthier
Donald R. Gauthier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11634511Abstract: The present invention provides processes for the preparation of sugammadex: (I) In one aspect, there is provided a process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and 3-mercaptopropionic acid. In another aspect, there is provided an alternative process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and disodium 3 -mercaptopropionate. In another aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclod extrin, which may be used in the production of sugammadex. In one such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-y-cyclodextrin from ?-cyclodextrin and a brominating agent. In another such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin comprising, inter alia, reacting ?-cyclodextrin with an electrophilic brominating agent, a deoxygenating agent, and an acid in the presence of an organic solvent.Type: GrantFiled: June 3, 2019Date of Patent: April 25, 2023Assignee: Merck Sharp & Dohme LLCInventors: Jamie M. McCabe Dunn, Nadine Kuhl, Wenyong Chen, Yang Cao, Donald R. Gauthier, Jr., Alan Michael Hyde, Susan L. Zultanski
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Patent number: 11542279Abstract: The instant invention is related to a novel solid form of ceftolozane sulfate (the DMAc solvate of ceftolozane sulfate (Form 3)), compositions comprising ceftolozane sulfate DMAc solvate (Form 3), synthesis of Form 3 and an improved crystallization process using Form 3 to prepare ceftolozane sulfate Form 2. Novel compositions also include ceftolozane sulfate solid Form 3 and/or other crystalline and amorphous solid forms of ceftolozane.Type: GrantFiled: June 1, 2017Date of Patent: January 3, 2023Assignee: Merck Sharp & Dohme LLCInventors: Kevin Matthew Maloney, Eric M. Sirota, Richard J. Varsolona, Donald R. Gauthier, Jr., Hong Ren
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Publication number: 20220056045Abstract: The instant invention is related to a novel solid form of ceftolozane sulfate (the DMAc solvate of ceftolozane sulfate (Form 3)), compositions comprising ceftolozane sulfate DMAc solvate (Form 3), synthesis of Form 3 and an improved crystallization process using Form 3 to prepare ceftolozane sulfate Form 2. Novel compositions also include ceftolozane sulfate solid Form 3 and/or other crystalline and amorphous solid forms of ceftolozane.Type: ApplicationFiled: June 1, 2017Publication date: February 24, 2022Applicant: Merck Sharp & Dohme Corp.Inventors: Kevin Matthew Maloney, Eric M. Sirota, Richard J. Varsolona, Donald R. Gauthier, Jr., Hong Ren
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Publication number: 20210206884Abstract: The present invention provides processes for the preparation of sugammadex: (I) In one aspect, there is provided a process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and 3-mercaptopropionic acid. In another aspect, there is provided an alternative process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and disodium 3-mercaptopropionate. In another aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin, which may be used in the production of sugammadex. In one such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin from ?-cyclodextrin and a brominating agent. In another such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin comprising, inter alia, reacting ?-cyclodextrin with an electrophilic brominating agent, a deoxygenating agent, and an acid in the presence of an organic solvent.Type: ApplicationFiled: June 3, 2019Publication date: July 8, 2021Applicant: Merck Sharp & Dohme Corp.Inventors: Jamie M. McCabe Dunn, Nadine Kuhl, Wenyong Chen, Yang Cao, Donald R. Gauthier, Jr., Alan Michael Hyde, Susan L. Zultanski
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Patent number: 9663490Abstract: The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans.Type: GrantFiled: December 4, 2013Date of Patent: May 30, 2017Assignee: Merck Sharp & Dohme Corp.Inventors: Tetsuji Itoh, Ingyu Jeon, Ian Mangion, Gang Qian, Benjamin D. Sherry, Donald R. Gauthier, Yang Cao
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Patent number: 9598397Abstract: The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase and HIV replication, and the treatment of human immunodeficiency virus infection in humans.Type: GrantFiled: December 2, 2014Date of Patent: March 21, 2017Assignee: Merck Sharp & Dohme Corp.Inventors: Yang Cao, Donald R. Gauthier, Jr., Guy R. Humphrey, Tetsuji Itoh, Michel Journet, Gang Qian, Benjamin D. Sherry, David M. Tschaen
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Publication number: 20160297794Abstract: The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase and HIV replication, and the treatment of human immunodeficiency virus infection in humans.Type: ApplicationFiled: December 2, 2014Publication date: October 13, 2016Applicant: MERCK SHARP & DOHME CORP.Inventors: Yang Cao, Donald R. Gauthier, Jr., Guy R. Humphrey, Tetsuji Itoh, Michel Journet, Gang Qian, Benjamin D. Sherry, David M. Tschaen
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Publication number: 20150329521Abstract: The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans.Type: ApplicationFiled: December 4, 2013Publication date: November 19, 2015Applicant: Merck Sharp & Dohme Corp.Inventors: Tetsuji Itoh, Ingyu Jeon, Ian Mangion, Gang QIAN, Benjamin D. Sherry, Donald R. Gauthier, Yang CAO
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Patent number: 8791162Abstract: This invention relates to deuterated compounds which are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.Type: GrantFiled: February 9, 2012Date of Patent: July 29, 2014Assignee: Merck Sharp & Dohme Corp.Inventors: Kelem Kassahun, Christine Fandozzi, Donald R. Gauthier, Jr., Lisa A. Shipley
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Publication number: 20130324610Abstract: This invention relates to deuterated compounds which are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.Type: ApplicationFiled: February 9, 2012Publication date: December 5, 2013Applicant: MERCK SHARP & DOHME CORP.Inventors: Kelem Kassahun, Christne Fandozzi, Donald R. Gauthier, Lisa A. Shipley
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Patent number: 7923459Abstract: The present invention is directed to processes for the preparation of 4-(3-methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and an oxidant; to give a compound of the formula (III): followed by catalytic reduction of the compound of formula (III).Type: GrantFiled: April 10, 2007Date of Patent: April 12, 2011Assignee: NSAB, Filial AF Neurosearch Sweden AB, SverigeInventors: Donald R. Gauthier, Richard Desmond, Paul N. Devine
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Patent number: 4472308Abstract: Azo dyestuffs of the formulae: ##STR1## which are useful for reactively dyeing such cellulosic materials as cotton or cotton/polyester blends.Type: GrantFiled: June 17, 1980Date of Patent: September 18, 1984Assignee: ICI United States, Inc.Inventor: Donald R. Gauthier
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Patent number: 4472168Abstract: Lithium salts of fiber reactive dyestuffs are stabilized in aqueous solution with N,N dialkylamine benzene sulfonic acid salt/acid buffers.Type: GrantFiled: July 5, 1983Date of Patent: September 18, 1984Assignee: ICI Americas Inc.Inventor: Donald R. Gauthier
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Patent number: 4230618Abstract: Azo dyestuffs of the formula: ##STR1## wherein A is a phenylene or naphthalene nucleus containing at least one phosphoric or phosphonic acid group; R.sub.1 and R.sub.2 are hydrogen or --SO.sub.3 H; and R.sub.3 -R.sub.6 are hydrogen, --SO.sub.3 H, or NR.sub.7 Q wherein R.sub.7 is hydrogen or lower alkyl and Q is hydrogen or an acyl group of 2 to 8 carbon atoms, at least two of R.sub.1 -R.sub.6 being --SO.sub.3 H and at least one being --NHQ, provided that when the dyestuff is monoazo, then Q is an acyl group of 3 to 8 carbons and when the dyestuff is disazo, Q is hydrogen or an acyl group of 2 to 8 carbon atoms. The dyestuff may be used to reactively dye cellulosic materials, e.g., cotton or cotton/polyester blends. The dyestuffs are particularly useful in dyeing mixed fabrics of cellulose and synthetics together with disperse dyes from a single bath.Type: GrantFiled: September 27, 1977Date of Patent: October 28, 1980Assignee: ICI United States, Inc.Inventor: Donald R. Gauthier
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Patent number: 4225491Abstract: Azo pyridone dyestuffs containing at least one reactive phosphoric or phosphonic acid group. The dyestuffs are characterized by the formula:A -- N .dbd. N -- Rwherein A is an aromatic radical containing at least one phosphoric or phosphonic acid group and R is a monovalent radical derived from a pyridone coupling component by removing a hydrogen atom attached to a ring carbon atom of the pyridone ring. The aromatic radical A is preferably a phenyl or naphthyl group. In addition to its phosphonic or phosphoric acid group or groups, radical A may be substituted with one or more halogen, alkyl, alkoxy, nitro, sulfonic acid or carboxylic acid groups. Cellulosic textiles, e.g., cotton or cotton/polyester blends, may be reactively dyed with these dyestuffs in an acid, neutral or alkaline bath using dicyandiamide or the equivalent. The phosphoric or phosphonic acid groups and the cellulosic material react to fix the dye through an ester linkage.Type: GrantFiled: September 12, 1977Date of Patent: September 30, 1980Assignee: ICI United States, Inc.Inventor: Donald R. Gauthier