Patents by Inventor Donald T. Moir
Donald T. Moir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11459308Abstract: The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GPCL) with its host receptor Niemann-Pick C1 (NPC1) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.Type: GrantFiled: December 5, 2017Date of Patent: October 4, 2022Assignees: Microbiotix, Inc., Albert Einstein College of Medicine, The Government of the United States as Represented by the Secretary of the ArmyInventors: Terry L. Bowlin, Donald T. Moir, Kartik Chandran, John M. Dye, Jr., John D. Williams, Zachary D. Aron, Jay P. Barbor, Kelly N. Lively, Peter J. Nash, Debra M. Mills, Arnab Basu
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Publication number: 20190292165Abstract: The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GPCL) with its host receptor Niemann-Pick C1 (NPC1) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.Type: ApplicationFiled: December 5, 2017Publication date: September 26, 2019Applicants: Microbiotix, Inc., Albert Einstein College Of Medicine, Inc., The Govermnment Of The United States As Represented By The Secretary Of The ArmyInventors: Terry L. Bowlin, Donald T. Moir, Kartik Chandran, John M. Dye, John D. Williams, Zachary D. Aron, Jay P. Barbor, Kelly N. Lively, Peter J. Nash, Debra M. Mills, Arnab Basu
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Patent number: 9340551Abstract: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Psendomonas spp., Yersinia spp., en tero pathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.Type: GrantFiled: July 13, 2012Date of Patent: May 17, 2016Assignee: MICROBIOTIX, INC.Inventors: Donald T. Moir, Daniel Aiello, Norton P. Peet, John D. Williams, Matthew Torhan
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Patent number: 8906945Abstract: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.Type: GrantFiled: April 6, 2010Date of Patent: December 9, 2014Assignee: Microbiotix, Inc.Inventors: Donald T. Moir, Daniel Aiello, Norton P. Peet, John D. Williams
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Publication number: 20140219995Abstract: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.Type: ApplicationFiled: July 13, 2012Publication date: August 7, 2014Applicant: MICROBIOTIX, INC.Inventors: Donald T. Moir, Daniel Aiello, Norton P. Peet, John D. Williams, Matthew Torhan
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Publication number: 20140142134Abstract: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Psendomonas spp., Yersinia spp., en tero pathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.Type: ApplicationFiled: July 13, 2012Publication date: May 22, 2014Applicant: MICROBIOTIX, INC.Inventors: Donald T. Moir, Daniel Aiello, Norton P. Peet, John D. Williams, Matthew Torhan
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Publication number: 20120114633Abstract: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.Type: ApplicationFiled: April 6, 2010Publication date: May 10, 2012Inventors: Donald T. Moir, Daniel Aiello, Norton P. Peet, John D. Williams
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Publication number: 20120064062Abstract: Organic compounds showing the ability to inhibit bacterial omptin proteases, specifically Yersinia pestis plasminogen activator (Pla) are disclosed. The disclosed Y. pestis plasminogen activator inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by Y. pestis.Type: ApplicationFiled: September 13, 2011Publication date: March 15, 2012Inventors: Jon D. Goguen, Daniel Aiello, Donald T. Moir, Bing Li
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Patent number: 7595872Abstract: A Raman scattering spectrographic analyzer wherein a microscope objective is adapted to view single bio-specimens on a substrate having monodispersed-sized metal particles. A defined wavelength of radiation is applied through the microscope and returning radiation resulting from Raman scattering by bio-specimens is applied to a spectrometer operative to provide a signal corresponding to the wavelength components in said Raman scattered or shifted radiation. The spread spectrum of the Raman shift is analyzed for identification of a bio-specimen.Type: GrantFiled: December 5, 2005Date of Patent: September 29, 2009Assignees: Trustees of Boston University, Microbiotix, Inc.Inventors: W. Ranjith Premasiri, Larry Ziegler, Donald T. Moir
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Publication number: 20080123093Abstract: A Raman scattering spectrographic analyzer wherein a microscope objective is adapted to view single bio-specimens on a substrate having monodispersed-sized metal particles. A defined wavelength of radiation is applied through the microscope and returning radiation resulting from Raman scattering by bio-specimens is applied to a spectrometer operative to provide a signal corresponding to the wavelength components in said Raman scattered or shifted radiation. The spread spectrum of the Raman shift is analyzed for identification of a bio-specimen.Type: ApplicationFiled: December 5, 2005Publication date: May 29, 2008Inventors: W. Ranjith Premasiri, Larry Ziegler, Donald T. Moir
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Publication number: 20040052799Abstract: Recombinant or substantially pure preparations of H. pylori polypeptides are described. The nucleic acids encoding the polypeptides also are described. The H. pylori polypeptides are useful for diagnostics and vaccine compositions.Type: ApplicationFiled: December 30, 2002Publication date: March 18, 2004Applicant: Astra AktiebolagInventors: Douglas Smith, Richard A. Alm, O. Thomas Berglindh, Bjorn L. Mellgard, Steven R. Thomas, Eric Brown, Donald T. Moir, Lo See Ling, Gilles Carmel, Braydon C. Guild, Peter C. Doig, Zita Kabok, Lillian Marie Castriotta
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Publication number: 20030108872Abstract: The invention relates to methods and systems of determining targets of compounds and compositions, as well as a high through-put method of screening antimicrobial agents. The methods involve (i) the prediction of a target using two and preferably at least three different submethods, (ii) identifying the gene encoding the target by each of these submethods, (iii) analysing the potential targets of each submethod to predict the putative target, and (iv) validating the target and the drug which perturbs it.Type: ApplicationFiled: August 23, 2001Publication date: June 12, 2003Inventors: Mark Sulavik, Losee Lucy Ling, Tim Opperman, Donald T. Moir, Christopher Bunker
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Patent number: 5525484Abstract: Living cells containing genetic material derived from recombinant DNA material and capable of expressing rennin, pre-prorennin and prorennin. The rennin, pre-prorennin and prorennin are derived from cells which are themselves or have had parents thereof treated by recombinant DNA methods to allow production of the desired enzymatic proteins during growth in culture.Type: GrantFiled: June 5, 1987Date of Patent: June 11, 1996Assignee: Genome Therapeutics Corp.Inventors: Bernadette L. Alford, Jen-I Mao, Donald T. Moir, Alison Taunton-Rigby, Gerald F. Vovis
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Patent number: 5496711Abstract: Living cells containing genetic material derived from recombinant DNA material and capable of expressing rennin, pre-prorennin and prorennin. The rennin, pre-prorennin and prorennin are derived from cells which are themselves or have had parents thereof treated by recombinant DNA methods to allow production of the desired enzymatic proteins during growth in culture.Type: GrantFiled: July 12, 1989Date of Patent: March 5, 1996Assignee: Genome Therapeutics Corp.Inventors: Bernadette L. Alford, Jen-I Mao, Donald T. Moir, Alison Taunton-Rigby, Gerald F. Vovis
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Patent number: 5139936Abstract: A DNA segment contains a GAL1 promoter of Saccharomyces cerevisae linked to a gene other than the galoctokinase gene, for directing the expression of the gene within a yeast cell.A GAL1 promoter portion of Saccharomyces cerevisae is linked to a foreign DNA segment for use in expressing a desired protein. Yeast cells containing the GAL1 promoter linked to a foreign DNA segment are grown in a medium containing glucose, wherein the yeast cells metabolize the glucose and are permitted to express a polypeptide when galactose is present in the medium.Type: GrantFiled: December 13, 1988Date of Patent: August 18, 1992Assignee: Collaborative Research, Inc.Inventors: David Botstein, Ronald W. Davis, Gerald R. Fink, Alison Taunton-Rigby, Robert G. Knowlton, Jen-i Mao, Donald T. Moir, Christopher G. Goff
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Patent number: 4666847Abstract: Living cells containing genetic material derived from recombinant DNA material and capable of expressing rennin, pre-prorennin and prorennin. The rennin, pre-prorennin and prorennin are derived from cells which are themselves or have had parents thereof treated by recombinant DNA methods to allow production of the desired enzymatic proteins during growth in culture.Type: GrantFiled: December 1, 1981Date of Patent: May 19, 1987Assignee: Collaborative Research, Inc.Inventors: Bernadette L. Alford, Jen-I Mao, Donald T. Moir, Alison Taunton-Rigby, Gerald F. Vovis
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Patent number: 4661454Abstract: A DNA segment containing a GAL1 promoter linked to a gene other than the galactokinase gene for directing the expression of the gene within a yeast cell.Type: GrantFiled: February 28, 1983Date of Patent: April 28, 1987Assignee: Collaborative Research, Inc.Inventors: David Botstein, Ronald W. Davis, Gerald R. Fink, Alison Taunton-Rigby, Robert G. Knowlton, Jen-i Mao, Donald T. Moir, Christopher G. Goff