Patents by Inventor Donald Wellings
Donald Wellings has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11273207Abstract: The invention provides a blood substitute product comprising haemoglobin and a self-assembled microparticle having an acid having two or more acid groups and an organic base in a solvent. The particle is of micron scale. The microparticle may be obtained by contacting a bis-acid and organic base in a hydrophilic solvent, wherein the acid is insoluble or sparingly soluble in the hydrophilic solvent and the organic base is soluble in a hydrophilic solvent.Type: GrantFiled: October 2, 2019Date of Patent: March 15, 2022Assignee: Spheritech Ltd.Inventor: Donald A. Wellings
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Publication number: 20210284609Abstract: Described herein are heterocyclic azide-containing monomer units, copolymers comprising such heterocyclic azide-containing monomer units, substrate-bound copolymers, and oligonucleotide-bound copolymers, methods for making such copolymers and reacting them with a substrate and/or oligonucleotide, and methods of using such copolymers for immobilization of oligonucleotides to a substrate, for example for use in DNA sequencing or other diagnostic applications.Type: ApplicationFiled: December 9, 2019Publication date: September 16, 2021Inventors: Wayne N. George, Xiaolin Wu, Andrew A. Brown, Donald Wellings
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Publication number: 20200230032Abstract: The invention provides a personal care product or a home care product having self-assembled microparticles having an acid having two or more acid groups and an organic base in a solvent. The microparticles may form into a macrostructure and provide a support for carrying components of a personal care or home care composition. The particle is of micron scale. The microparticle may be obtained by contacting a bis-acid and organic base in a hydrophilic solvent, wherein the acid is insoluble or sparingly soluble in the hydrophilic solvent and the organic base is soluble in a hydrophilic solvent.Type: ApplicationFiled: December 5, 2019Publication date: July 23, 2020Inventor: Donald A. Wellings
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Publication number: 20200038490Abstract: The invention provides a blood substitute product comprising haemoglobin and a self-assembled microparticle having an acid having two or more acid groups and an organic base in a solvent. The particle is of micron scale. The microparticle may be obtained by contacting a bis-acid and organic base in a hydrophilic solvent, wherein the acid is insoluble or sparingly soluble in the hydrophilic solvent and the organic base is soluble in a hydrophilic solvent.Type: ApplicationFiled: October 2, 2019Publication date: February 6, 2020Inventor: Donald A. Wellings
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Patent number: 10500140Abstract: The invention provides a personal care product or a home care product having self-assembled microparticles having an acid having two or more acid groups and an organic base in a solvent. The microparticles may form into a macrostructure and provide a support for carrying components of a personal care or home care composition. The particle is of micron scale. The microparticle may be obtained by contacting a bis-acid and organic base in a hydrophilic solvent, wherein the acid is insoluble or sparingly soluble in the hydrophilic solvent and the organic base is soluble in a hydrophilic solvent.Type: GrantFiled: September 5, 2017Date of Patent: December 10, 2019Assignee: Spheritech Ltd.Inventor: Donald A. Wellings
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Patent number: 10471130Abstract: The invention provides a blood substitute product comprising haemoglobin and a self-assembled microparticle having an acid having two or more acid groups and an organic base in a solvent. The particle is of micron scale. The microparticle may be obtained by contacting a bis-acid and organic base in a hydrophilic solvent, wherein the acid is insoluble or sparingly soluble in the hydrophilic solvent and the organic base is soluble in a hydrophilic solvent.Type: GrantFiled: September 5, 2017Date of Patent: November 12, 2019Assignee: Spheritech Ltd.Inventor: Donald A. Wellings
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Publication number: 20190216691Abstract: The invention provides a personal care product or a home care product having self-assembled microparticles having an acid having two or more acid groups and an organic base in a solvent. The microparticles may form into a macrostructure and provide a support for carrying components of a personal care or home care composition. The particle is of micron scale. The microparticle may be obtained by contacting a bis-acid and organic base in a hydrophilic solvent, wherein the acid is insoluble or sparingly soluble in the hydrophilic solvent and the organic base is soluble in a hydrophilic solvent.Type: ApplicationFiled: September 5, 2017Publication date: July 18, 2019Inventor: Donald A. WELLINGS
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Publication number: 20190201497Abstract: The invention provides a blood substitute product comprising haemoglobin and a self-assembled microparticle having an acid having two or more acid groups and an organic base in a solvent. The particle is of micron scale. The microparticle may be obtained by contacting a bis-acid and organic base in a hydrophilic solvent, wherein the acid is insoluble or sparingly soluble in the hydrophilic solvent and the organic base is soluble in a hydrophilic solvent.Type: ApplicationFiled: September 5, 2017Publication date: July 4, 2019Inventor: Donald A. WELLINGS
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Patent number: 10266652Abstract: The invention provides a non-particulate cross-linked poly-?-lysine polymer. The poly-?-lysine and cross linker are linked by amide bonds and may the cross linker has at least two functional groups capable of reacting with an alpha carbon amine of poly-?-lysine. The polymer is suitably insoluble in water and other solvents and is provided in macro form for example a sheet, article or fiber. The macro form polymer is useful in a wide range of applications including wound treatment, as a medical diagnostic comprising a particulate support and a functional material bound or retained by the support and solid phase synthesis of peptides, oligonucleotides, oligosaccharides, immobilisation of species, cell culturing and in chromatographic separation.Type: GrantFiled: March 15, 2018Date of Patent: April 23, 2019Assignee: SPHERITECH LTD.Inventor: Donald A. Wellings
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Publication number: 20190023844Abstract: The invention provides a non-particulate cross-linked poly-?-lysine polymer. The poly-?-lysine and cross linker are linked by amide bonds and may the cross linker has at least two functional groups capable of reacting with an alpha carbon amine of poly-?-lysine. The polymer is suitably insoluble in water and other solvents and is provided in macro form for example a sheet, article or fibre. The macro form polymer is useful in a wide range of applications including wound treatment, as a medical diagnostic comprising a particulate support and a functional material bound or retained by the support and solid phase synthesis of peptides, oligonucleotides, oligosaccharides, immobilisation of species, cell culturing and in chromatographic separation.Type: ApplicationFiled: March 15, 2018Publication date: January 24, 2019Inventor: Donald A. Wellings
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Patent number: 9938378Abstract: The invention provides a non-particulate cross-linked poly-?-lysine polymer. The poly-?-lysine and cross linker are linked by amide bonds and may the cross linker has at least two functional groups capable of reacting with an alpha carbon amine of poly-?-lysine. The polymer is suitably insoluble in water and other solvents and is provided in macro form for example a sheet, article or fiber. The macro form polymer is useful in a wide range of applications including wound treatment, as a medical diagnostic comprising a particulate support and a functional material bound or retained by the support and solid phase synthesis of peptides, oligonucleotides, oligosaccharides, immobilization of species, cell culturing and in chromatographic separation.Type: GrantFiled: April 20, 2012Date of Patent: April 10, 2018Assignee: SPHERITECH LTDInventor: Donald Wellings
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Publication number: 20180036702Abstract: The invention provides a self-assembled microparticle having an acid having two or more acid groups and an organic base in a solvent. The microparticles may form into a macrostructure and provide a scaffold for cell culture. The particle is of micron scale. The microparticle may be obtained by contacting a bis-acid and organic base in a hydrophilic solvent, wherein the acid is insoluble or sparingly soluble in the hydrophilic solvent and the organic base is soluble in a hydrophilic solvent. The microparticles have antimicrobial activity and may be used in a wide range of consumer product applications, cell culture and medical products, such as wound dressings.Type: ApplicationFiled: March 3, 2016Publication date: February 8, 2018Inventor: Donald A. Wellings
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Patent number: 8906404Abstract: Provided herein is a three dimensional porous structure formed around an array of particles, where the particles define pores in the structure. The structure retreats away from the surface of the particles during formation, such that the particles optionally remain within the pores in the structure.Type: GrantFiled: September 16, 2010Date of Patent: December 9, 2014Assignee: Spheritech Ltd.Inventor: Donald A. Wellings
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Publication number: 20140154737Abstract: The invention provides a cross-linked poly-?-lysine polymer. The poly-?-lysine and cross linker are linked by amide bonds and may the cross linker has at least two functional groups capable of reacting with an alpha carbon amine of poly-?-lysine. The polymer is suitably insoluble in water and other solvents and is provided in particulate form. The invention provides a particulate support comprising the cross-linked poly-?-lysine polymer and the polymer may provide the particle itself or be coated on a particle for example silica. The polymer is useful in a wide range of applications including wound treatment, as a medical diagnostic comprising a particulate support and a functional material bound or retained by the support and solid phase synthesis of peptides, oligonucleotides, oligosaccharides, immobilisation of species, cell culturing and in chromatographic separation.Type: ApplicationFiled: April 20, 2012Publication date: June 5, 2014Applicant: SPHERITECH LTDInventor: Donald Wellings
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Publication number: 20140142198Abstract: The invention provides a non-particulate cross-linked poly-?-lysine polymer. The poly-?-lysine and cross linker are linked by amide bonds and may the cross linker has at least two functional groups capable of reacting with an alpha carbon amine of poly-?-lysine. The polymer is suitably insoluble in water and other solvents and is provided in macro form for example a sheet, article or fibre. The macro form polymer is useful in a wide range of applications including wound treatment, as a medical diagnostic comprising a particulate support and a functional material bound or retained by the support and solid phase synthesis of peptides, oligonucleotides, oligosaccharides, immobilisation of species, cell culturing and in chromatographic separation.Type: ApplicationFiled: April 20, 2012Publication date: May 22, 2014Applicant: SPHERITECH LTDInventor: Donald Wellings
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Publication number: 20130267681Abstract: The invention discloses processes for preparing compounds comprising an ?-amino acid motif. The compounds are useful in e.g. the chemical ligation of peptides.Type: ApplicationFiled: August 12, 2011Publication date: October 10, 2013Applicant: THE UNIVERSITY OF READINGInventors: Laurence Marius Harwood, Donald A. Wellings, David John Moody
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Publication number: 20120309053Abstract: A 3-dimensional porous polymeric structure comprising a porous polymer structure optionally with particles within the pores of the polymer and wherein the pores have a narrow pore-size distribution. The structure may be made by closely packing particles in a zone to provide a 3-dimensional array, contacting a polymerisable monomer with the array such that the composition fills interstitial spaces between the particles and effecting polymerisation of the monomer whereby a polymer structure is formed around the particles and optionally removing the particles from the structure. The 3-dimensional porous structure may be used in solid phase synthesis, immobilisation, cell culturing and preparation of a stationary phase for chromatographic separation, as an absorbent, an insulating material or in tissue regeneration.Type: ApplicationFiled: September 16, 2010Publication date: December 6, 2012Applicant: SPHERITECH LTDInventor: Donald A. Wellings
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Publication number: 20120237606Abstract: A particulate body having a hollow particle and a surface polymer disposed on the outside of the hollow particle and suitable for use in solid phase synthesis, especially production of peptides and oligonucleotides. The particulate body may be used as a chromatography stationary phase column and the buoyancy of the body allows the column to be packed efficiently from the bottom reducing the risk of damage to the stationary phase. The buoyancy of the particulate body may also allow species for example a catalyst to be suspended in a liquid phase to allow reactions, for example hydrolysis of vegetable oil and esterification to produce biodiesel to be carried out with a reduced risk of catalyst loss from a reaction zone.Type: ApplicationFiled: September 16, 2010Publication date: September 20, 2012Applicant: SPHERITECH LTDInventor: Donald A. Wellings
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Publication number: 20060036028Abstract: A process for the preparation of an oligonucleotide is provided. The process comprises the assembly of an oligonucleotide attached to a solid support, wherein the solid support is prepared by a process comprising polymerisation of a monomer which comprises a protected hydroxypolyC2-4 alkyleneoxy chain attached to a polymerisable unit wherein the protected hydroxypolyC2-4 alkyleneoxy chain contains from 2 to 10 C2-4 alkyleneoxy groups and wherein the hydroxypolyC2-4 alkyleneoxy chain is protected with an acid-labile protecting group, preferably an optionally substituted trityl group.Type: ApplicationFiled: April 25, 2003Publication date: February 16, 2006Inventors: David Moody, Donald Wellings, Paul McCormac
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Publication number: 20050266520Abstract: A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching a ?-nitrogen protect C?-carboxamide amino acid to a solid support by its side chain, removing the ?-nitrogen protecting group, assembling a peptide chain on said ?-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.Type: ApplicationFiled: May 2, 2003Publication date: December 1, 2005Inventors: David Evans, Dean Simpkin, Donald Wellings, Eric Atherton