Abstract: The present disclosure relates to 4,6,7-trisubstituted 1,2-dihydropyrrolo[3,4-c]pyridin/pyrimidin-3-one derivatives, and their preparations and medicinal use. Specifically, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof, wherein the definition of each group is as described in the specification and claims.

Abstract: This application discloses an emoji recommendation method and apparatus. The method includes: displaying a first user interface of a social network client application; detecting occurrence of a trigger event that corresponds to a preset condition for triggering delivery of an emoji recommendation from the social network server to a first user; retrieving one or more emoji recommendations from the social network server, wherein the one or more emoji recommendations are selected from an emoji library for the first user in accordance with social behavior information of the first user; and displaying the one or more emoji recommendations on the first user interface, including displaying one or more editing controls to adjust one or more parameters for calculating a correlation degree of the user and a respective emoji based on one or more attributes of the one or more emoji recommendations retrieved from the social network server.

Abstract: A video processing method, apparatus, and device and a storage medium are provided. The method includes: monitoring an operation indication inputted by a user through a personal homepage on a social platform, the personal homepage being used for displaying personal information of the user; obtaining, when the operation indication is a shooting indication for shooting a personal status video, the personal status video; uploading the personal status video to a back-end server of the social platform; and displaying indication information of the personal status video in a personal-information display region of the personal homepage.

Abstract: A patient interface includes a frame, an inflatable seal, and a deformable insert. The frame includes an outer portion, an inner portion, and an opening extending therebetween. The inflatable seal is secured to the inner portion of the frame. The inflatable seal defines an internal volume and has at least one aperture. The deformable insert includes an outer surface, an inner surface and a passageway extending therebetween. The deformable insert is positioned within the internal volume of the seal and aligned with at least a portion of the frame inner portion. The passageway is aligned with the frame opening to define a gas flow path from the frame outer portion to the at least one aperture of the seal.

Abstract: An animated emoticon generation method, a computer-readable storage medium, and a computer device are provided. The method includes: displaying an emoticon input panel on a chat page; detecting whether a video shooting event is triggered in the emoticon input panel; acquiring video data in response to detecting the video shooting event; obtaining an edit operation for the video data; processing video frames in the video data according to the edit operation to synthesize an animated emoticon; and adding an emoticon thumbnail corresponding to the animated emoticon to the emoticon input panel, the emoticon thumbnail displaying the animated emoticon to be used as a message on the chat page based on a user selecting the emoticon thumbnail in the emoticon input panel.

Abstract: Systems, methods, and non-transitory computer readable media can obtain a first image depicting a face of a user. A plurality of images depicting the face of the user can be identified. A second image of the plurality of images can be identified based on one or more factors. The face or a portion of the face of the user in the first image can be replaced with the face or a portion of the face of the user in the second image.

Abstract: A ballooning patient interface has a frame that supports a sealing member. The frame and/or the sealing member is secured to the head of a user with headgear, such as a strap. Various features of the sealing member improve comfort for the user in the nares of the users as well as on facial surfaces in contact with the sealing member.

Abstract: Therapeutic methods for cancer treatments using a combined prokaryotic-eukaryotic delivery and expression system for the delivery of multiple therapeutic factors via a modified tumor-targeted bacteria. A targeted bacteria-vector system elicits an inter-kingdom dual expression (IKDE) of antitumor agents, in the nucleus or cytoplasm of eukaryotic cells, with priming and maintenance of the vector in the bacterium. The therapeutic factors include small interfering RNAs, tumoricidal proteins, DNA molecules, or a combination thereof. The system provides direct killing of tumor cells and alters the tumor microenvironment by expressing anti-angiogenic factors and cytokines in intracellular and/or extracellular environments. Also provided are methods of using natural exosomes comprising cargoes obtained from the bacterially infected cells. The bacteria-vector system is useful for many types of tumor and cancer as well as recombinant vaccines.

Abstract: A patient interface includes a frame, an inflatable seal, and a deformable insert. The frame includes an outer portion, an inner portion, and an opening extending therebetween. The inflatable seal is secured to the inner portion of the frame. The inflatable seal defines an internal volume and has at least one aperture. The deformable insert includes an outer surface, an inner surface and a passageway extending therebetween. The deformable insert is positioned within the internal volume of the seal and aligned with at least a portion of the frame inner portion. The passageway is aligned with the frame opening to define a gas flow path from the frame outer portion to the at least one aperture of the seal.

Abstract: A Doppler fetal heartbeat monitor includes: a housing; a mainboard; a loudspeaker installed in the housing and electrically connected to the mainboard; and an ultrasonic transducer installed in the housing, electrically connected to the mainboard, and comprising at least one transduction wafer configured to generate an impulse wave, in which the ultrasonic transducer is internally provided at a head end of the housing, and the loudspeaker and the mainboard are internally provided at a tail end of the housing. By arranging the loudspeaker, the mainboard and the ultrasonic transducer in the housing, the Doppler fetal heartbeat monitor can have a compact structure and a small volume. Moreover, it is possible to reduce positive feedback of a sound system and a probability of a self-excited whistle.

Abstract: A ballooning patient interface has a frame that supports a sealing member. The frame and/or the sealing member is secured to the head of a user with headgear, such as a strap. Various features of the sealing member improve comfort for the user in the nares of the users as well as on facial surfaces in contact with the sealing member.

Abstract: A method, including: at a client terminal of a user of a social network platform: displaying a first network resource published by a first resource publisher; displaying a resource rewarding affordance in association with the first network resource or an identifier of the first resource publisher; detecting user selection of the resource rewarding affordance; and in accordance with a determination that the resource rewarding affordance has been selected while the resource rewarding affordance is displayed in association with the first network resource or the identifier of the first resource publisher, initiating a resource rewarding operation to reward the first resource publisher on the social network platform, wherein the resource rewarding operation transfers reward goods from a social network account of the user to a social network account of the first resource publisher on the social network platform.

Abstract: The present invention discloses an N-sulfonyl benzamide derivative with a heterocyclic substituent, and a preparation method therefor and a pharmaceutical application thereof. More specifically, the invention discloses a compound represented by formula (II) or a pharmaceutically acceptable salt, stereoisomer, solvent compound, or prodrug thereof, and a preparation method therefor and an application thereof. Refer to the specification for definitions of each group in the formula.

Abstract: A patient interface has a single loop headstrap and a mask for covering at least the nostrils of the user. The single loop headstrap extends from the mask at either end. A short length of supple conduit is coupled to the mask by a swivel or ball joint to allow rotation of the conduit relative to the mask through different angles and orientations.

Abstract: A respiratory mask system includes a mask interface and a headgear assembly. The headgear assembly is adjustable and comprised of an elastic portion, a non-elastic portion and a restriction mechanism configured to provide a force resisting movement of the non-elastic portion when the elastic portion is extended. There is a support beam coupled to the non-elastic portion and extending along a portion of the headgear that is curved along its longitudinal extent. In this way particular seal modules can be comfortably fitted to a user and any blow off force is mitigated. A particular example of the respiratory mask system includes provision for removable attachment between the seal and a mask frame, the mask frame and a yoke of the headgear; and between a conduit and the mask frame.

Abstract: The present disclosure relates to 4,6,7-trisubstituted 1,2-dihydropyrrolo[3,4-c]pyridin/pyrimidin-3-one derivatives, and their preparations and medicinal use. Specifically, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof, wherein the definition of each group is as described in the specification and claims.