Abstract: Provided is a fusion protein dimer using an antibody Fc region as the backbone, comprising a first and a second polypeptide chain. The first polypeptide chain comprises a first antibody Fc region and one or more single-domain antibodies fused to the first antibody Fc region. The second polypeptide chain comprises a second antibody Fc region and one or more single domain antibodies fused to the second antibody Fc region. The first polypeptide chain and/or the second polypeptide chain further comprise a cytokine fused to the Fc region of the respective antibody. Further provided is use of the fusion protein dimer in preparing an immunotherapeutic drug for treating tumors. The Fc fusion protein heterodimer not only increases the activity of a single domain antibody, but also significantly improves the biological activity of a cytokine.

Abstract: Disclosed is an adjustment mechanism for an electric power-driven shoe, the mechanism comprising a shoe sole (1), wherein a plurality of rolling wheels (2) are arranged below the shoe sole (1); a foot-positioning mechanism is arranged above the shoe sole (1) and is provided with an angle-adjusting mechanism for adjusting an angle between the foot-positioning mechanism and a lengthwise direction of the shoe sole (1).

Abstract: An adjustment mechanism for an electric power-driven shoe, the mechanism comprising a shoe sole (1) is presented, wherein a plurality of rolling wheels (2) are arranged below the shoe sole (1); a foot-positioning mechanism is arranged above the shoe sole (1) and is provided with an angle-adjusting mechanism for adjusting an angle between the foot-positioning mechanism and a lengthwise direction of the shoe sole (1).

Abstract: A device for mixing a medical agent and associated systems and methods are disclosed herein. In some embodiments, the device comprises (i) a housing defining a chamber configured to contain a fluid and having a longitudinal axis, (ii) a plunger assembly at least partially disposed within the chamber, the plunger assembly comprising a plunger and a stirring member extending along the longitudinal axis, and (iii) an actuating assembly operably coupled to the stirring member. The actuating assembly can have an active state in which the actuating assembly causes a distal end portion of the stirring member to rotate at a predetermined speed.

Abstract: Disclosed is an adjustment mechanism for an electric power-driven shoe, the mechanism comprising a shoe sole (1), wherein a plurality of rolling wheels (2) are arranged below the shoe sole (1); a foot-positioning mechanism is arranged above the shoe sole (1) and is provided with an angle-adjusting mechanism for adjusting an angle between the foot-positioning mechanism and a lengthwise direction of the shoe sole (1).

Abstract: Disclosed is an anti-reverse rotation device of a power-driven shoe device, the power-driven shoe device comprising a shoe sole (1), wherein a group of front wheels (2) and a group of rear wheels (3) are arranged on a lower side surface of the shoe sole (1); and the front wheels (2) are connected to an anti-reverse rotation mechanism for preventing the front wheels (2) from rotating in reverse. The anti-reverse rotation mechanism can prevent the front wheels (2) from rotating in reverse, and as such, when the front wheels (2) are independently in contact with the ground and a certain included angle is formed between a shoe body and the ground, the situation of the front wheels (2) applying a certain pressure to the ground and the front wheels (2) rotating in reverse, such that a lifted foot moves backwards, thereby causing a person to fall down, is avoided, and walking safety is improved.

Abstract: Disclosed is a bionic electric power-driven shoe, comprising a shoe sole (1), wherein a plurality of rotating wheels (2) are arranged below the shoe sole (1); an electric motor (3) is further provided at a lower part of the shoe sole (1); an output end of the electric motor (3) is connected to a transmission device in driving connection with the rotating wheels (2); and the shoe sole (1) comprises a heel part (11) and a sole part (12), the heel part (11) and the sole part (12) being in rotational connection.

Abstract: Disclosed is a power-driven shoe device, comprising a shoe sole (1), wherein a plurality of rotating wheels (2) are arranged below the shoe sole (1); an electric motor (3) is further provided at a lower part of the shoe sole (1); an output end of the electric motor (3) is connected to a transmission device; the transmission device is in driving connection with the rotating wheels (2); rotating wheel brackets (6) for having the rotating wheels (2) mounted thereon are arranged on two sides of a lower side surface of the shoe sole (1); and the transmission device comprises a driving wheel (4), a multistage deceleration structure and a planetary speed reducer, the multistage deceleration structure being disposed, in a lengthwise direction of the shoe sole (1), on the rotating wheel brackets (6).

Abstract: Disclosed is a bionic electric power-driven shoe, comprising a shoe sole (1), wherein a plurality of rotating wheels (2) are arranged below the shoe sole (1); an electric motor (3) is further provided at a lower part of the shoe sole (1); an output end of the electric motor (3) is connected to a transmission device in driving connection with the rotating wheels (2); and the shoe sole (1) comprises a heel part (11) and a sole part (12), the heel part (11) and the sole part (12) being in rotational connection.

Abstract: Disclosed is an anti-reverse rotation device of a power-driven shoe device, the power-driven shoe device comprising a shoe sole (1), wherein a group of front wheels (2) and a group of rear wheels (3) are arranged on a lower side surface of the shoe sole (1); and the front wheels (2) are connected to an anti-reverse rotation mechanism for preventing the front wheels (2) from rotating in reverse. The anti-reverse rotation mechanism can prevent the front wheels (2) from rotating in reverse, and as such, when the front wheels (2) are independently in contact with the ground and a certain included angle is formed between a shoe body and the ground, the situation of the front wheels (2) applying a certain pressure to the ground and the front wheels (2) rotating in reverse, such that a lifted foot moves backwards, thereby causing a person to fall down, is avoided, and walking safety is improved.

Abstract: Disclosed is a power-driven shoe device, comprising a shoe sole (1), wherein a plurality of rotating wheels (2) are arranged below the shoe sole (1); an electric motor (3) is further provided at a lower part of the shoe sole (1); an output end of the electric motor (3) is connected to a transmission device; the transmission device is in driving connection with the rotating wheels (2); rotating wheel brackets (6) for having the rotating wheels (2) mounted thereon are arranged on two sides of a lower side surface of the shoe sole (1); and the transmission device comprises a driving wheel (4), a multistage deceleration structure and a planetary speed reducer, the multistage deceleration structure being disposed, in a lengthwise direction of the shoe sole (1), on the rotating wheel brackets (6).

Abstract: An implant for treatment of a vascular space can form open loops and closed loops in separate cycles to provide balanced stiffness and flexibility. Such an implant provides both stability for retention within the vascular space and conformability for mitigating forces on the vasculature. Such a configuration can also provide proper coverage over an opening to a vascular space into which the implant is delivered, for reducing or eliminating flow into or out of the body cavity and promoting occlusion of the vascular space.