Abstract: Provided is a fusion protein dimer using an antibody Fc region as the backbone, comprising a first and a second polypeptide chain. The first polypeptide chain comprises a first antibody Fc region and one or more single-domain antibodies fused to the first antibody Fc region. The second polypeptide chain comprises a second antibody Fc region and one or more single domain antibodies fused to the second antibody Fc region. The first polypeptide chain and/or the second polypeptide chain further comprise a cytokine fused to the Fc region of the respective antibody. Further provided is use of the fusion protein dimer in preparing an immunotherapeutic drug for treating tumors. The Fc fusion protein heterodimer not only increases the activity of a single domain antibody, but also significantly improves the biological activity of a cytokine.

Abstract: Systems and methods for automated first arrival picking are disclosed. The method includes obtaining a seismic dataset composed of a plurality of seismic gathers and determining a pilot for each gather, where the pilot includes a position on an ordinate axis for each seismic trace representing a first arrival. The method continues iteratively until a stopping criterion is met by creating a preconditioned gather using the pilot, determining a differential pilot using global path tracing subject to a constraint and incrementing the pilot using the differential pilot to create a total picked first arrival. Once the stopping criterion has been met, the method further includes determining a final picked first arrival based on the total picked first arrival, determining a seismic velocity model from the final picked first arrival using a tomographic inversion and creating a seismic image using the seismic velocity model and the seismic dataset.

Abstract: A capillary clip, a capillary electrophoresis apparatus, and a method for using a capillary clip. The capillary clip comprises a clip body, and a refrigerant channel, and at least two capillary channels defined by the clip body. The clip body comprises an inlet segment clip portion (100), a detection portion (200), and an outlet combination portion (300), wherein the inlet segment clip portion (100), the detection portion (200) and the outlet combination portion (300) are detachably connected in sequence in a sealed manner. The refrigerant channel and each capillary channel are combined at the inlet segment clip portion (100) and the outlet combination portion (300), and the refrigerant channel and each capillary channel are separated at a detection window (201) of the detection portion (200). A capillary (700) can be mounted in the capillary channel.

Abstract: Disclosed is an adjustment mechanism for an electric power-driven shoe, the mechanism comprising a shoe sole (1), wherein a plurality of rolling wheels (2) are arranged below the shoe sole (1); a foot-positioning mechanism is arranged above the shoe sole (1) and is provided with an angle-adjusting mechanism for adjusting an angle between the foot-positioning mechanism and a lengthwise direction of the shoe sole (1).

Abstract: An optical element detachable capillary clip and a capillary electrophoresis apparatus. The capillary clip comprises at least one capillary channel and a clip body defining the at least one capillary channel, and a capillary (700) can be mounted in the capillary channel. The clip body is provided with a detection window (201) and at least one optical detection element, the at least one optical detection element being directly or indirectly connected in the detection window (201). The at least one optical detection element can be removed from the clip body, such that the detection window (201) exposes at least part of an unobstructed region.

Abstract: A method for determining an internal multiple attenuated seismic image is disclosed. The method includes obtaining a seismic dataset composed of a plurality of seismic traces and for each seismic trace determining an internal multiple trace based, at least in part, on a nested truncated correlation and a bounded convolution of the seismic trace with itself. The method further includes determining an internal multiple attenuated seismic trace based, at least in part, on subtracting the internal multiple trace from the seismic trace and combining the internal multiple attenuated seismic trace to form the internal multiple attenuated seismic image. A system including a seismic source, a plurality of seismic receivers, and a seismic processor for executing the method is disclosed.

Abstract: Disclosed are a trifluoromethyl alkenylphosphonate derivative and preparation method therefor. The preparation method comprises the following steps: dissolving an acetylene derivative, an iodine compound, and a phosphorus reagent in a solvent for reaction at the temperature from the room temperature to 100° C. to obtain the trifluoromethyl alkenylphosphonate derivative. In the present invention, the acetylene derivative is used as a starting material, and the raw materials are easily available and diversified; products obtained by using the method of the present invention have various types and can be directly used and also used for other further reactions; moreover, the method disclosed in the present invention has the advantages of short steps, mild reaction conditions, simple reaction operation and post-treatment processes, and high yield, and is suitable for large-scale production.

Abstract: Various embodiments for a transport dispatch system for route selection are described herein. An embodiment operates by determining the total quantity of goods to be shipped to the plurality of railway stations. A plurality of variations of the shipping route are identified. A user-provided metric is computing for each of the plurality of variations of the shipping route. A first variation is identified from the plurality of variations of the shipping route for which the computed user-provided metric is lower than a remainder of the plurality of variations of the shipping route, The first variation of the shipping route is provided indicating an order in which each of the plurality of stations receives its portion of the total quantity of goods based on its request.

Abstract: Various embodiments for a transport dispatch system for route selection are described herein. An embodiment operates by determining the total quantity of goods to be shipped to the plurality of railway stations, wherein the total quantity of goods exceeds a capacity of a single train that is to deliver the total quantity of goods to the plurality of railway stations across a plurality of requests. The distances between each of the plurality of railway stations and a dispatch station are determined. It is determined that some stations are in one direction from a dispatch station, and another set of stations are in a different direction. A metric for selecting one of a plurality of variations of the shipping route is identified. The metric is computed for each of the plurality of variations of the shipping route, and a first variation with a lowest metric is selected.

Abstract: Various embodiments for a transport dispatch system for trailer assignment are described herein. An embodiment operates by determining the total quantity of goods to be shipped to the plurality of railway stations, the total quantity of goods comprising a plurality of different materials. A plurality of different types of shipping containers for transporting the different materials are determined. A command to identify the trailer assignment for shipping the total quantity of goods to the plurality of railway stations is received. The trailer assignment for shipping the total quantity of goods to the plurality of railway stations using a fewest number of the shipping containers is computed. The trailer assignment indicating the fewest number of shipping containers that can be used to ship the plurality of different materials to the plurality of railway stations is provided.

Abstract: A periodic optimization method for a diffractive optical element includes converting coordinates of individual target spots of a target spot array into angular spectrum coordinates, selecting an initial period, calculating diffraction orders of individual target spots, rounding the diffraction order, calculating the coordinates of actual projection spots by using the rounded diffraction orders, calculating evaluation indicator of period optimization, adjusting the period, and repeating the steps, and comparing the evaluation indicators to determine an optimal period for the diffractive optical element. With the periodic optimization method, an actual spot array is made to match a target spot array to the greatest possible extent with a small amount of calculations, thereby improving the design quality and accuracy of a diffractive optical element.

Abstract: A periodic optimization method for a diffractive optical element includes converting coordinates of individual target spots of a target spot array into angular spectrum coordinates, selecting an initial period, calculating diffraction orders of individual target spots, rounding the diffraction order, calculating the coordinates of actual projection spots by using the rounded diffraction orders, calculating evaluation indicator of period optimization, adjusting the period, and repeating the steps, and comparing the evaluation indicators to determine an optimal period for the diffractive optical element. With the periodic optimization method, an actual spot array is made to match a target spot array to the greatest possible extent with a small amount of calculations, thereby improving the design quality and accuracy of a diffractive optical element.

Abstract: A method may include obtaining seismic data for a geological region of interest. The method may further include determining various velocity semblance values for the geological region of interest using a time window and the seismic data. The method may further include determining, automatically by a computer processor, one or more stacking velocities for the geological region of interest using a traced path based on the velocity semblance values and a path tracing algorithm. The path tracing algorithm may recursively determine an accumulated amplitude array based on the velocity semblance values. The path tracing algorithm may further determine the traced path among the velocity semblance values and the accumulated amplitude array, the traced path corresponding to the one or more stacking velocities. The method may further include generating a velocity model of the geological region of interest using the one or more stacking velocities.

Abstract: A method for determining an internal multiple attenuated seismic image is disclosed. The method includes obtaining a seismic dataset composed of a plurality of seismic traces and for each seismic trace determining an internal multiple trace based, at least in part, on a nested truncated correlation and a bounded convolution of the seismic trace with itself. The method further includes determining an internal multiple attenuated seismic trace based, at least in part, on subtracting the internal multiple trace from the seismic trace and combining the internal multiple attenuated seismic trace to form the internal multiple attenuated seismic image. A system including a seismic source, a plurality of seismic receivers, and a seismic processor for executing the method is disclosed.

Abstract: The present invention discloses a prestressed-bolted dry-assembled segmental precast hybrid tower with grouting-free, comprising a top steel tower tube, a reverse self-balancing steal-concrete transition section, and a prestressed-bolted dry-assembled segmental precast concrete tower with grouting-free dry fast splicing and a gear reinforced wind turbine foundation; the steel tower tube, the steel-concrete transition section, the concrete tower tube and the hollow wind turbine foundation are integrally connected from top to bottom through a prestressed steel strand system to improve the overall bending resistance of the tower; the upper end of the prestressed steel strands is anchored to the steel-concrete transition section, and the lower end is anchored to the bottom face of the wind turbine foundation corbel; the concrete tower tube is composed of a number of segmental tapered precast concrete tower segments, which are grouting free spliced vertically, and the vertical splicing utilizes positioning pins to

Abstract: Methods and systems for determining an interbed multiple attenuated pre-stack seismic dataset are disclosed. The methods include forming a post-stack seismic image composed of post-stack traces from the pre-stack seismic dataset and identifying a first, second, and third post-stack horizon on each of the post-stack traces. The methods further include for each pre-stack trace, generating a first, second, and third multiple-generator trace based on the first, second and third post-stack horizon and determining a correlation trace based, at least in part, on a correlation between the first multiple-generator trace and the second multiple-generator trace.

Abstract: A system for seismic imaging of a subterranean geological formation, the system includes a receiver configured to obtain seismic data comprising a data volume representing a post-stacked image. The system includes a filtering module configured to: apply frequency-wavenumber (F-K) filter to the data volume extract a negative-dip structure image and apply the frequency-wavenumber (F-K) filter to the data volume extract a positive-dip structure image. The system includes a diffraction rendering module configured to: multiply the positive-dip structure image with the negative-dip structure image and generate a diffraction-enhanced seismic image representing a geological formation of the data volume.

Abstract: A method for preparing a ?-amino phosphonic acid derivative includes: dissolving N-(arylvinyl)benzamide, dialkyl phosphite, manganese acetate, and potassium carbonate in a solvent and reacting at room temperature to obtain (2-benzamido-1-arylvinyl)dialkyl-phosphonate derivative; and hydrolyzing (2-benzamido-1-arylethyl)dialkylphosphonate derivative to obtain ?-amino phosphonic acid derivative. The N-(arylvinyl)benzamide derivative is used as starting material. The raw materials are easy to obtain and are of many different types. A method of preparing ?-aminophosphonic acid derivative includes: dissolving N-(arylvinyl)benzamide, dialkyl phosphite, manganese acetate and potassium carbonate in a solvent, reacting at room temperature to obtain (2-benzamide-1-arylvinyl) dialkyl phosphonate derivative, and then reducing and hydrolyzing the compound to obtain ?-aminophosphonic acid derivative.

Abstract: A system for seismic imaging of a subterranean geological formation uses a two-way imaging condition. A seismic signal is emitted into a subterranean formation and recorded at receiver(s). Source and receiver wavefields are decomposed into respective right-down/left-up and left-down/right-up propagating waves. The right-down/left-up and left-down/right-up direction can be defined along the direction emitted from the source or receiver to corresponding direction in two dimensional (2D) case. An imaging condition for generating both a positive-dip structure image and a negative-dip structure image is the inner product of the wavefields. Applying the sample-by-sample multiplication imaging condition to the opposite dip images, the diffraction energy is retained while the reflection energy is significantly attenuated. The diffraction image can be used to detect faults and fractures in subsurface regions.

Abstract: A method of generating diffraction images based on wave equations includes generating a source wavefield and a receiver wavefield. Based on the source wavefield, a first source wavefield propagating in a first direction and a second source wavefield propagating in a second direction are generated. Based on the receiver wavefield, a first receiver wavefield propagating in the first direction and a second receiver wavefield propagating in the second direction are generated. A first seismic image is generated based on the first source wavefield and the first receiver wavefield. A second seismic image is generated based on the second source wavefield and the second receiver wavefield. A final seismic image is generated based on the first seismic image and the second seismic image.