Patents by Inventor Dong-Xiao Zhang
Dong-Xiao Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7846453Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.Type: GrantFiled: June 15, 2006Date of Patent: December 7, 2010Assignee: Genentech, Inc.Inventors: Paul J. Godowski, Melanie Rose Mark, Dong Xiao Zhang
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Patent number: 7662585Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.Type: GrantFiled: September 17, 2004Date of Patent: February 16, 2010Assignee: Genentech, Inc.Inventors: Paul J. Godowski, Melanie Rose Mark, Dong-Xiao Zhang
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Publication number: 20080096215Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.Type: ApplicationFiled: October 29, 2007Publication date: April 24, 2008Applicant: Genentech, Inc.Inventors: Avi Ashkenazi, Audrey Goddard, Austin Gurney, Paul Polakis, Victoria Smith, William Wood, Thomas Wu, Dong-Xiao Zhang
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Publication number: 20060051351Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain; a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.Type: ApplicationFiled: October 21, 2005Publication date: March 9, 2006Inventors: Paul Godowski, Melanie Mark, Dong-Xiao Zhang
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Patent number: 6994856Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.Type: GrantFiled: June 30, 1998Date of Patent: February 7, 2006Assignee: Genentech, Inc.Inventors: Paul J. Godowski, Melanie Rose Mark, Dong-Xiao Zhang
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Publication number: 20050164250Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.Type: ApplicationFiled: November 19, 2004Publication date: July 28, 2005Applicant: Genentech, Inc.Inventors: Avi Ashkenazi, Audrey Goddard, Austin Gurney, Paul Polakis, Victoria Smith, William Wood, Thomas Wu, Dong-Xiao Zhang
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Publication number: 20050048622Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.Type: ApplicationFiled: September 17, 2004Publication date: March 3, 2005Inventors: Paul Godowski, Melanie Mark, Dong-Xiao Zhang
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Publication number: 20030185800Abstract: The invention concerns a novel human interferon-&egr;, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-&agr; family and from IFNs-&bgr; and -&ggr;. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production and use are also included.Type: ApplicationFiled: April 17, 2003Publication date: October 2, 2003Applicant: Genentech, Inc.Inventors: Jian Chen, Paul Godowski, William I. Wood, Dong-Xiao Zhang
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Patent number: 6569420Abstract: The invention concerns a novel human interferon-&egr;, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-&agr; family and from IFNs-&bgr; and -&ggr;. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production are also included.Type: GrantFiled: July 30, 2001Date of Patent: May 27, 2003Assignee: Genentech, Inc.Inventors: Jian Chen, Paul Godowski, William I. Wood, Dong-Xiao Zhang
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Publication number: 20030036166Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.Type: ApplicationFiled: August 9, 2002Publication date: February 20, 2003Applicant: Genentech, Inc.Inventors: Paul J. Godowski, Melanie Rose Mark, Dong Xiao Zhang
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Publication number: 20020172660Abstract: The invention concerns a novel human interferon-&egr;, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-&agr; family and from IFNs-&bgr; and -&ggr;. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production are also included.Type: ApplicationFiled: July 30, 2001Publication date: November 21, 2002Applicant: Genentech, Inc.Inventors: Jian Chen, Paul Godowski, William I. Wood, Dong-Xiao Zhang
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Publication number: 20020164680Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.Type: ApplicationFiled: June 8, 2001Publication date: November 7, 2002Applicant: Genentech, Inc.Inventors: Paul J. Godowski, Melanie Rose Mark, Dong-Xiao Zhang
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Publication number: 20020161200Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.Type: ApplicationFiled: April 29, 2002Publication date: October 31, 2002Applicant: Genentech, Inc.Inventors: Paul J. Godowski, Melanie Rose Mark, Dong Xiao Zhang
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Publication number: 20020082229Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain; a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.Type: ApplicationFiled: March 26, 2001Publication date: June 27, 2002Applicant: Genentech, Inc.Inventors: Paul J. Godowski, Melanie Rose Mark, Dong-Xiao Zhang
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Patent number: 6299869Abstract: The invention concerns a human interferon-&egr;, originally designated PRO655, and its variants and derivatives. The interferon is related to but distinct from members of the IFN-&agr; family and from IFNs-&bgr; and -&ggr;. Nucleic acid encoding the polpypeptide, and methods and means for their recombinant production are also included.Type: GrantFiled: March 4, 1999Date of Patent: October 9, 2001Assignee: Genentech, Inc.Inventors: Jian Chen, Paul Godowski, William I. Wood, Dong-Xiao Zhang
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Patent number: 6299877Abstract: The invention concerns a novel human interferon-&egr;, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-&agr; family and from IFNs-&bgr; and -&ggr;. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production are also included.Type: GrantFiled: December 7, 1998Date of Patent: October 9, 2001Assignee: Genentech, Inc.Inventors: Jian Chen, Paul Godowski, William I. Wood, Dong-Xiao Zhang
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Patent number: 6252051Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.Type: GrantFiled: July 30, 1998Date of Patent: June 26, 2001Assignee: Genentech, Inc.Inventors: Paul J. Godowski, Melanie Rose Mark, Dong Xiao Zhang
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Patent number: 6200780Abstract: The invention concerns a novel human interferon-&egr;, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-&agr; family and from IFNs-&bgr; and -&ggr;. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production are also included.Type: GrantFiled: December 7, 1998Date of Patent: March 13, 2001Assignee: Genentech, Inc.Inventors: Jian Chen, Paul J. Godowski, William I. Wood, Dong-Xiao Zhang
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Patent number: 6121415Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.Type: GrantFiled: July 24, 1997Date of Patent: September 19, 2000Assignee: Genentech, Inc.Inventors: Paul J. Godowski, Melanie Rose Mark, Dong Xiao Zhang