Patents by Inventor Dongxing Zha
Dongxing Zha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11976128Abstract: The present disclosure is directed to antibodies binding to PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L2.Type: GrantFiled: March 15, 2019Date of Patent: May 7, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Michael A. Curran, Ashvin R. Jaiswal, Dongxing Zha, Kui Voo, Carlo Toniatti, Bianka Prinz, Nadthakarn Boland
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Publication number: 20240043538Abstract: The present disclosure is directed to antibodies binding to PD-L1 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1.Type: ApplicationFiled: November 17, 2022Publication date: February 8, 2024Applicant: Board of Regents, The University of Texas SystemInventors: Michael A. CURRAN, Carlo TONIATTI, Ashvin R. JAISWAL, Dongxing ZHA, Kui VOO, Bianka PRINZ, Nadthakarn BOLAND
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Publication number: 20230174661Abstract: The present disclosure is directed to antibodies binding to PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L2.Type: ApplicationFiled: March 15, 2019Publication date: June 8, 2023Applicant: Board of Regents, The University of Texas SystemInventors: Michael A. CURRAN, Ashvin R. JAISWAL, Dongxing ZHA, Kui VOO, Carlo TONIATTI, Bianka PRINZ, Nadthakarn BOLAND
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Patent number: 11525002Abstract: The present disclosure is directed to antibodies binding to PD-L1 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1.Type: GrantFiled: October 10, 2018Date of Patent: December 13, 2022Assignee: Board of Regents, The University of Texas SystemInventors: Michael A. Curran, Carlo Toniatti, Ashvin R. Jaiswal, Dongxing Zha, Kui Voo, Bianka Prinz, Nadthakarn Boland
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Publication number: 20210317441Abstract: Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest.Type: ApplicationFiled: June 10, 2021Publication date: October 14, 2021Applicant: Merck Sharp & Dohme Corp.Inventors: Bianka Prinz, Natarajan Sethuraman, Dongxing Zha, Stefan Wildt, Piotr Bobrowicz
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Patent number: 11104721Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.Type: GrantFiled: September 17, 2018Date of Patent: August 31, 2021Assignee: Merck Sharp & Dohme Corp.Inventors: Dongxing Zha, Hussam Hisham Shaheen
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Publication number: 20210214445Abstract: The present disclosure is directed to dual specificity antibodies which may bind to PD-L1 or PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1 or PD-L2.Type: ApplicationFiled: March 15, 2019Publication date: July 15, 2021Applicant: Board of Regents, The University of Texas SystemInventors: Michael A. CURRAN, Ashvin R. JAISWAL, Dongxing ZHA, Kui VOO, Carlo TONIATTI, Bianka PRINZ, Nga Rewa HOUSTON, Eric KRAULAND
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Publication number: 20210198360Abstract: The present disclosure is directed to antibodies binding to PD-L1 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1.Type: ApplicationFiled: October 10, 2018Publication date: July 1, 2021Applicant: Board of Regents, The University of Texas SystemInventors: Michael A. CURRAN, Carlo TONIATTI, Ashvin R. JAISWAL, Dongxing ZHA, Kui VOO, Bianka PRINZ, Nadthakam BOLAND
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Patent number: 11046951Abstract: Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest.Type: GrantFiled: October 3, 2018Date of Patent: June 29, 2021Assignee: Merck Sharp & Dohme Corp.Inventors: Bianka Prinz, Natarajan Sethuraman, Dongxing Zha, Stefan Wildt, Piotr Bobrowicz
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Publication number: 20210139591Abstract: The present disclosure is directed to bispecific antibodies which bind to both PD-L1 and PD-L2, and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1, PD-L2, or both.Type: ApplicationFiled: March 14, 2019Publication date: May 13, 2021Applicant: Board of Regents, The University of Texas SystemInventors: Michael A. CURRAN, Ashvin R. JAISWAL, Dongxing ZHA, Carlo TONIATTI, Bianka PRINZ, Nadthakarn BOLAND, Eric KRAULAND
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Patent number: 10858686Abstract: The present invention is directed to methods and compositions for the production of Fc-containing polypeptides having improved properties and comprising mutations at positions 243 and 264 of the Fc region.Type: GrantFiled: June 13, 2018Date of Patent: December 8, 2020Assignee: Merck Sharp & Dohme Corp.Inventors: Terrance A. Stadheim, Dongxing Zha
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Patent number: 10577600Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest.Type: GrantFiled: January 10, 2018Date of Patent: March 3, 2020Assignee: Merck Sharp & Dohme Corp.Inventors: Hussam Hisham Shaheen, Dongxing Zha
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Publication number: 20190055546Abstract: Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest.Type: ApplicationFiled: October 3, 2018Publication date: February 21, 2019Applicant: Merck Sharp & Dohme Corp.Inventors: Bianka Prinz, Natarajan Sethuraman, Dongxing Zha, Stefan Wildt, Piotr Bobrowicz
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Publication number: 20190040118Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.Type: ApplicationFiled: September 17, 2018Publication date: February 7, 2019Applicant: Merck Sharp & Dohme Corp.Inventors: Dongxing Zha, Hussam Hisham Shaheen
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Publication number: 20180346951Abstract: The present invention is directed to methods and compositions for the production of Fc-containing polypeptides having improved properties and comprising mutations at positions 243 and 264 of the Fc region.Type: ApplicationFiled: June 13, 2018Publication date: December 6, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Terrance A. Stadheim, Dongxing Zha
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Patent number: 10106598Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.Type: GrantFiled: May 25, 2016Date of Patent: October 23, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Dongxing Zha, Hussam Hisham Shaheen
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Publication number: 20180142233Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest.Type: ApplicationFiled: January 10, 2018Publication date: May 24, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Hussam Hisham Shaheen, Dongxing Zha
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Patent number: 9890378Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest.Type: GrantFiled: May 6, 2013Date of Patent: February 13, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Hussam Hisham Shaheen, Dongxing Zha
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Publication number: 20180002402Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.Type: ApplicationFiled: May 25, 2016Publication date: January 4, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Dongxing Zha, Hussam Hisham Shaheen
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Patent number: 9845464Abstract: Methods for display of recombinant proteins or protein libraries on the surface of lower eukaryotes such as yeast and filamentous fungi are described. The methods are useful for screening libraries of recombinant proteins in lower eukaryotes to identify particular proteins with desired properties from the array of proteins in the libraries. The methods are particularly useful for constructing and screening antibody libraries in lower eukaryotes.Type: GrantFiled: October 17, 2014Date of Patent: December 19, 2017Assignee: GlycoFi, Inc.Inventors: Dongxing Zha, Stefan Wildt