Patents by Inventor Donmienne Doen Mun Leung

Donmienne Doen Mun Leung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-hepcidin antibodies and uses thereof
    Patent number: 8329174
    Abstract: Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: December 11, 2012
    Assignee: Eli Lilly and Company
    Inventors: Donmienne Doen Mun Leung, Barbara Anne Swanson, Ying Tang, Peng Luan, Derrick Ryan Witcher
  • Anti-ferroportin 1 monoclonal antibodies and uses thereof
    Patent number: 8183346
    Abstract: Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: May 22, 2012
    Assignee: Eli Lilly and Company
    Inventors: Donmienne Doen Mun Leung, Peng Luan, Joseph Vincent Manetta, Ying Tang, Derrick Ryan Witcher
  • ANTI-FERROPORTIN 1 MONOCLONAL ANTIBODIES AND USES THEREOF
    Publication number: 20120100148
    Abstract: Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
    Type: Application
    Filed: December 1, 2009
    Publication date: April 26, 2012
    Inventors: Donmienne Doen Mun Leung, Peng Luan, Joseph Vincent Manetta, Ying Tang, Derrick Ryan Witcher
  • ANTI-HEPCIDIN-25 SELECTIVE ANTIBODIES AND USES THEREOF
    Publication number: 20110189190
    Abstract: Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA.
    Type: Application
    Filed: July 29, 2009
    Publication date: August 4, 2011
    Applicant: ELI LILLY AND COMPANY
    Inventors: Donmienne Doen Mun Leung, Peng Luan, Ying Tang, Derrick Ryan Witcher, Pia Pauliina Yachi
  • ANTI-FERROPORTIN 1 MONOCLONAL ANTIBODIES AND USES THEREOF
    Publication number: 20110129480
    Abstract: Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
    Type: Application
    Filed: December 1, 2009
    Publication date: June 2, 2011
    Inventors: Donmienne Doen Mun Leung, Peng Luan, Joseph Vincent Manetta, Ying Tang, Derrick Ryan Witcher
  • ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF
    Publication number: 20110027261
    Abstract: Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
    Type: Application
    Filed: August 31, 2010
    Publication date: February 3, 2011
    Applicant: ELI LILLY AND COMPANY
    Inventors: Donmienne Doen Mun Leung, Barbara Anne Swanson, Ying Tang, Peng Luan, Derrick Ryan Witcher
  • Anti-hepcidin antibodies and uses thereof
    Patent number: 7820163
    Abstract: Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: October 26, 2010
    Assignee: Eli Lilly and Company
    Inventors: Donmienne Doen Mun Leung, Barbara Anne Swanson, Ying Tang, Peng Luan, Derrick Ryan Witcher
  • ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF
    Publication number: 20090136495
    Abstract: Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
    Type: Application
    Filed: October 29, 2008
    Publication date: May 28, 2009
    Inventors: Dennis Patrick Gately, Donmienne Doen Mun Leung, Barbara Anne Swanson, Ying Tang, YuPing Anthony Cai, LuHong He, Peng Luan, Derrick Ryan Witcher