Patents by Inventor Donna Dambach

Donna Dambach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of biomarkers for liver toxicity
    Patent number: 7452678
    Abstract: The present invention relates to biomarker polypeptides, polynucleotides, and antibodies that have utility in predicting in vitro and/or in vivo hepatotoxicity of various drugs, compounds, or other therapeutic agents (i.e., test substances). Also related are screens, kits, microarrays, and cell culture systems that employ the polypeptides, polynucleotides, and/or antibodies of the invention. The reagents and methods of the invention are useful for predicting hepatotoxic effects resulting from treatment with one or more test substances, and can be utilized before, after, or concurrently with pre-clinical, clinical, and/or post-clinical testing. In this way, the reagents and methods of the invention can be used to identify test substances or combinations of test substances that cause hepatic injury, including idiosyncratic hepatotoxicity, and thereby prevent medical complications (e.g., liver failure) resulting from such injury.
    Type: Grant
    Filed: June 22, 2004
    Date of Patent: November 18, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Stephen K. Durham, Donna Dambach, Stanley Hefta, Frederic Moulin, Ji Gao, Gregory Opiteck, Stephen M. Storm, Leah Ann Garulacan, Jun-Hsiang Lin
  • Identification of biomarkers for liver toxicity
    Publication number: 20040265889
    Abstract: The present invention relates to biomarker polypeptides, polynucleotides, and antibodies that have utility in predicting in vitro and/or in vivo hepatotoxicity of various drugs, compounds, or other therapeutic agents (i.e., test substances). Also related are screens, kits, microarrays, and cell culture systems that employ the polypeptides, polynucleotides, and/or antibodies of the invention. The reagents and methods of the invention are useful for predicting hepatotoxic effects resulting from treatment with one or more test substances, and can be utilized before, after, or concurrently with pre-clinical, clinical, and/or post-clinical testing. In this way, the reagents and methods of the invention can be used to identify test substances or combinations of test substances that cause hepatic injury, including idiosyncratic hepatotoxicity, and thereby prevent medical complications (e.g., liver failure) resulting from such injury.
    Type: Application
    Filed: June 22, 2004
    Publication date: December 30, 2004
    Inventors: Stephen K. Durham, Donna Dambach, Stanley Hefta, Frederic Moulin, Ji Gao, Gregory Opiteck, Stephen M. Storm, Leah Ann Garulacan, Jun-Hsiang Lin