Patents by Inventor Donna G. Albertson
Donna G. Albertson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9809841Abstract: The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits the identification of small sequence differences (e.g., sequence divergence of 1% or less) in nucleic acid samples of high complexity (e.g., an entire genome).Type: GrantFiled: April 20, 2016Date of Patent: November 7, 2017Assignee: The Regents of the University of CaliforniaInventors: Donna G. Albertson, Daniel Pinkel, Yevgeniya Fridlyand, Bing Huey, Antoine Snijders
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Patent number: 9753035Abstract: The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases.Type: GrantFiled: September 11, 2007Date of Patent: September 5, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Pinkel, Donna G. Albertson, Joe W. Gray
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Publication number: 20160340718Abstract: The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits the identification of small sequence differences (e.g., sequence divergence of 1% or less) in nucleic acid samples of high complexity (e.g., an entire genome).Type: ApplicationFiled: April 20, 2016Publication date: November 24, 2016Inventors: Donna G. Albertson, Daniel Pinkel, Jane Fridyland, Bing Huey, Antoine Snijders
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Publication number: 20140187441Abstract: This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.Type: ApplicationFiled: February 6, 2014Publication date: July 3, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donna G. Albertson, Daniel Pinkel, Colin Collins, Joe W. Gray, Bauke Ylstra
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Patent number: 8685929Abstract: This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.Type: GrantFiled: April 10, 2012Date of Patent: April 1, 2014Assignee: The Regents of the University of CaliforniaInventors: Donna G. Albertson, Daniel Pinkel, Colin Collins, Joe W. Gray, Bauke Ylstra
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Publication number: 20130225420Abstract: The present invention provides methods of analyzing a sample from a subject having oral epithelial dysplasia or oral SCC or suspected of having oral epithelial dysplasia or oral SCC.Type: ApplicationFiled: August 2, 2011Publication date: August 29, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donna G. Albertson, Brian L. Schmidt, Aditi Bhattacharya, Adam B. Olshen
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Publication number: 20120322674Abstract: This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.Type: ApplicationFiled: April 10, 2012Publication date: December 20, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donna G. Albertson, Daniel Pinkel, Colin Collins, Joe W. Gray, Bauke Ylstra
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Patent number: 8283181Abstract: This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.Type: GrantFiled: July 9, 2008Date of Patent: October 9, 2012Assignee: The Regents of the University of CaliforniaInventors: Daniel Pinkel, Donna G. Albertson, Greg Hamilton, Nils W. Brown, Robert Nordmeyer
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Patent number: 8173602Abstract: This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.Type: GrantFiled: December 8, 2009Date of Patent: May 8, 2012Assignee: The Regents of the University of CaliforniaInventors: Donna G. Albertson, Daniel Pinkel, Colin Collins, Joe W. Gray, Bauke Ylstra
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Publication number: 20100285023Abstract: This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.Type: ApplicationFiled: December 8, 2009Publication date: November 11, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donna G. Albertson, Daniel Pinkel, Colin Collins, Joe W. Gray, Bauke Ylstra
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Publication number: 20100279876Abstract: The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits the identification of small sequence differences (e.g., sequence divergence of 1% or less) in nucleic acid samples of high complexity (e.g., an entire genome).Type: ApplicationFiled: March 17, 2009Publication date: November 4, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donna G. Albertson, Daniel Pinkel, Jane Fridyland, Bing Huey, Antoine Snijders, Joe W. Gray, Anne Kallioniemi, Olli-Pekka Kallioniemi, Frederic Waldman
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Patent number: 7648826Abstract: This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.Type: GrantFiled: April 2, 1999Date of Patent: January 19, 2010Assignee: The Regents of the University of CaliforniaInventors: Donna G. Albertson, Daniel Pinkel, Colin Collins, Joe W. Gray, Bauke Ystra
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Patent number: 7534567Abstract: The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits the identification of small sequence differences (e.g., sequence divergence of 1% or less) in nucleic acid samples of high complexity (e.g., an entire genome).Type: GrantFiled: February 16, 2005Date of Patent: May 19, 2009Assignee: The Regents of the University of CaliforniaInventors: Donna G. Albertson, Daniel Pinkel, Jane Fridyland, Bing Huey, Antoine Snijders, Joe W. Gray, Anne Kallioniemi, Olli-Pekka Kallioniemi, Frederic Waldman
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Patent number: 7499166Abstract: This invention provides an imaging system for high-accuracy quantitative analysis of a microarray. In certain embodiments, the system comprises a broad band excitation light source that provides Kohler illumination of said microarray at an incident angle that ranges from about 30 degrees to about 75 degrees from the normal to the microarray, and that has less than about ±25 percent variation in intensity over the array at all wavelengths ranging from 400 to 800 nm; a support for holding a microarray; a detection lens system that is chromatically corrected so the apparent position of the microarray or a feature comprising the microarray varies by less than 10 ?m as the detection wavelength varies from about 400 to about 800 nm; and a detection device for detecting and optionally recording an image produced by said detection lens system.Type: GrantFiled: May 20, 2004Date of Patent: March 3, 2009Assignee: The Regents of the University of CaliforniaInventors: Donna G. Albertson, Daniel Pinkel
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Publication number: 20090029876Abstract: This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.Type: ApplicationFiled: July 9, 2008Publication date: January 29, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Pinkel, Donna G. Albertson, Greg Hamilton, Nils W. Brown, Robert Nordmeyer
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Patent number: 7402286Abstract: This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.Type: GrantFiled: December 15, 2004Date of Patent: July 22, 2008Assignee: The Regents of the University of CaliforniaInventors: Daniel Pinkel, Donna G. Albertson, Greg Hamilton, Nils W. Brown, Robert Nordmeyer
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Publication number: 20080132421Abstract: The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases.Type: ApplicationFiled: September 11, 2007Publication date: June 5, 2008Inventors: Daniel Pinkel, Donna G. Albertson, Joe W. Gray
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Patent number: 7312068Abstract: This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.Type: GrantFiled: June 6, 2003Date of Patent: December 25, 2007Assignee: The Regents of the University of CaliforniaInventors: Daniel Pinkel, Donna G. Albertson, Joe W. Gray, Greg Hamilton, Nils W. Brown, Steven M. Clark, John Hanson
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Patent number: 7267947Abstract: The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases.Type: GrantFiled: July 19, 2002Date of Patent: September 11, 2007Assignee: The Regents of the University of CaliforniaInventors: Daniel Pinkel, Donna G. Albertson, Joe W. Gray
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Patent number: 6855538Abstract: This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.Type: GrantFiled: June 27, 2001Date of Patent: February 15, 2005Assignee: The Regents of the University of CaliforniaInventors: Daniel Pinkel, Donna G. Albertson, Joe W. Gray, Greg Hamilton, Nils W. Brown, Steven M. Clark