Patents by Inventor Donna L. Faletto

Donna L. Faletto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of producing hepatocycte growth factor/scatter factor and related cell lines
    Patent number: 5871959
    Abstract: A method of preventing tumor cell metastasis by inhibiting the binding of hepatocyte growth factor/scatter factor ("HGF/SF") with met proto-oncogene protein is described. A method of producing HGF/SF and a cell line for the production of HGF/SF are also described. The met proto-oncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signalling system in which cells of mesenchymal origin produce the ligand, which binds to the receptor that is predominantly expressed in cells of epithelial origin. The method of the present invention disrupts the Met-HGF/SF autocrine signaling that contributes to the tumorigenic process in tumors of mesenchymal origin, such as sarcomas.
    Type: Grant
    Filed: November 18, 1994
    Date of Patent: February 16, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Sing Rong, George Vande Woude, Donna L. Faletto, Ilan Tsarfaty, Marianne Oskarsson