Patents by Inventor Donna McIntosh

Donna McIntosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREDICTING TUMOR RESPONSE TO ANTI-ERBB3 ANTIBODIES
    Publication number: 20180195120
    Abstract: A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.
    Type: Application
    Filed: November 27, 2017
    Publication date: July 12, 2018
    Inventors: Sylvie Vincent, Kristan Meetze, Bin Feng, Steven Tyler, Steve Bottega, Richard Nicoletti, Donna McIntosh, Jeno Gyuris
  • Predicting tumor response to anti-ERBB3 antibodies
    Patent number: 9828635
    Abstract: A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: November 28, 2017
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: Sylvie Vincent, Kristan Meetze, Bin Feng, Steven Tyler, Steve Bottega, Richard Nicoletti, Donna McIntosh, Jeno Gyuris
  • PREDICTING TUMOR RESPONSE TO ANTI-ERBB3 ANTIBODIES
    Publication number: 20140242597
    Abstract: A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.
    Type: Application
    Filed: October 5, 2012
    Publication date: August 28, 2014
    Applicant: AVEO PHARMACEUTICALS, INC.
    Inventors: Sylvie Vincent, Kristan Meetze, Bin Feng, Steven Tyler, Steve Bottega, Richard Nicoletti, Donna McIntosh, Jeno Gyuris
  • Synthesis of oligo/poly(catechins) and methods of use
    Patent number: 8143308
    Abstract: A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: March 27, 2012
    Assignees: University of Massachusetts Lowell, The United States of America, as represented by the Secretary of the Army
    Inventors: Ferdinando F. Bruno, Jayant Kumar, Subhalakshmi Nagarajan, Susan J. Braunhut, Ramaswamy Nagarajan, Lynne A. Samuelson, Donna McIntosh, Klaudia Foley
  • Synthesis of oligo/poly(catechins) and methods of use
    Publication number: 20090170928
    Abstract: A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.
    Type: Application
    Filed: October 29, 2007
    Publication date: July 2, 2009
    Inventors: Ferdinando F. Bruno, Jayant Kumar, Subhalakshmi Nagarajan, Susan J. Braunhut, Ramaswamy Nagarajan, Lynne A. Samuelson, Donna McIntosh, Klaudia Foley