Patents by Inventor Dorit Daniel
Dorit Daniel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230241220Abstract: A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of an ethylene oxide/propylene oxide block copolymer, HPMC, and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.Type: ApplicationFiled: March 31, 2023Publication date: August 3, 2023Inventors: Asher Holzer, Dorit Daniel, Michael Mullerad, Jaime De La Zerda, Uri Shpolansky, Nadav Malchi, Yosh Dollberg, Dor Tal, Yossi Yavin, Marina Konorty
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Publication number: 20230241221Abstract: A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of an ethylene oxide/propylene oxide block copolymer, HPMC, and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.Type: ApplicationFiled: March 31, 2023Publication date: August 3, 2023Inventors: Asher Holzer, Dorit Daniel, Michael Mullerad, Jaime De La Zerda, Uri Shpolansky, Nadav Malchi, Yosh Dollberg, Dor Tal, Yossi Yavin, Marina Konorty
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Publication number: 20230233685Abstract: A method of providing sustained-release topical treatment of a condition affecting an internal body cavity is provided. The method comprises administering a pharmaceutical composition comprising a thermoreversible hydrogel and an active pharmaceutical ingredient to an internal body cavity of the urinary tract. After administration, the concentration of the active pharmaceutical ingredient in urothelium of the internal body cavity is increased when compared to the concentration of the active pharmaceutical ingredient in urothelium of the internal body cavity following administration of a control composition comprising the same dose and concentration of active pharmaceutical ingredient in water.Type: ApplicationFiled: March 31, 2023Publication date: July 27, 2023Inventors: Asher Holzer, Dorit Daniel, Michael Mullerad, Jaime De La Zerda, Uri Shpolansky, Nadav Malchi, Yosh Dollberg, Dor Tal, Yossi Yavin, Marina Konorty
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Patent number: 10039832Abstract: A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.Type: GrantFiled: May 22, 2015Date of Patent: August 7, 2018Assignee: UROGEN PHARMA LTD.Inventors: Asher Holzer, Dorit Daniel, Michael Mullerad, Jaime De La Zerda, Uri Shpolansky, Nadav Malchi, Yosh Dollberg, Dor Tal, Yossi Yavin, Marina Konorty
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Patent number: 9950069Abstract: A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.Type: GrantFiled: December 1, 2016Date of Patent: April 24, 2018Assignee: UROGEN PHARMA LTD.Inventors: Asher Holzer, Dorit Daniel, Michael Mullerad, Jaime De La Zerda, Uri Shpolansky, Nadav Malchi, Yosh Dollberg, Dor Tal, Yossi Yavin, Marina Konorty
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Patent number: 9884028Abstract: Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution is coated onto at least a portion of the internal cavity, and acts as a slow-release drug delivery system.Type: GrantFiled: April 10, 2015Date of Patent: February 6, 2018Assignee: UroGen Pharma Ltd.Inventors: Asher Holzer, Dorit Daniel, Eran Hirszowicz
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Publication number: 20170112935Abstract: A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.Type: ApplicationFiled: December 1, 2016Publication date: April 27, 2017Applicant: UroGen Pharma Ltd.Inventors: Asher Holzer, Dorit Daniel, Michael Mullerad, Jaime De La Zerda, Uri Shpolansky, Nadav Malchi, Yosh Dollberg, Dor Tal, Yossi Yavin, Marina Konorty
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Publication number: 20150366974Abstract: A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.Type: ApplicationFiled: May 22, 2015Publication date: December 24, 2015Inventors: Asher Holzer, Dorit Daniel, Michael Mullerad, Jaime De La Zerda, Uri Shpolansky, Nadav Malchi, Yosh Dollberg, Dor Tal, Yossi Yavin, Marina Konorty
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Publication number: 20150209300Abstract: Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution is coated onto at least a portion of the internal cavity, and acts as a slow-release drug delivery system.Type: ApplicationFiled: April 10, 2015Publication date: July 30, 2015Inventors: Asher Holzer, Dorit Daniel, Eran Hirszowicz
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Patent number: 9040074Abstract: A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.Type: GrantFiled: July 19, 2012Date of Patent: May 26, 2015Assignee: Theracoat Ltd.Inventors: Asher Holzer, Dorit Daniel, Michael Mullerad, Jaime De La Zerda, Uri Shpolansky, Nadav Malchi, Yosh Dollberg, Dor Tal, Yossi Yavin, Marina Konorty
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Patent number: 9011411Abstract: Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution is coated onto at least a portion of the internal cavity, and acts as a slow-release drug delivery system.Type: GrantFiled: December 23, 2012Date of Patent: April 21, 2015Assignee: Theracoat Ltd.Inventors: Asher Holzer, Dorit Daniel, Eran Hirszowicz
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Patent number: 8936566Abstract: Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution is coated onto at least a portion of the internal cavity, and acts as a slow-release drug delivery system.Type: GrantFiled: December 23, 2012Date of Patent: January 20, 2015Assignee: Theracoat Ltd.Inventors: Asher Holzer, Dorit Daniel, Eran Hirszowicz
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Publication number: 20130110030Abstract: Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution is coated onto at least a portion of the internal cavity, and acts as a slow-release drug delivery system.Type: ApplicationFiled: December 23, 2012Publication date: May 2, 2013Applicant: Theracoat Ltd.Inventors: Asher HOLZER, Dorit DANIEL, Eran HIRSZOWICZ
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Publication number: 20130110031Abstract: Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution is coated onto at least a portion of the internal cavity, and acts as a slow-release drug delivery system.Type: ApplicationFiled: December 23, 2012Publication date: May 2, 2013Applicant: Theracoat Ltd.Inventors: Asher HOLZER, Dorit DANIEL, Eran HIRSZOWICZ
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Publication number: 20130046275Abstract: A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.Type: ApplicationFiled: July 19, 2012Publication date: February 21, 2013Applicant: THERACOAT LTD.Inventors: Asher HOLZER, Dorit DANIEL, Michael MULLERAD, Jaime DE LA ZERDA, Uri SHPOLANSKY, Nadav MALCHI, Yosh DOLLBERG, Dor TAL, Yossi YAVIN, Marina KONORTY
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Patent number: 8361490Abstract: Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution is coated onto at least a portion of the internal cavity, and acts as a slow-release drug delivery system.Type: GrantFiled: September 16, 2004Date of Patent: January 29, 2013Assignee: Theracoat Ltd.Inventors: Asher Holzer, Dorit Daniel, Eran Hirszowicz
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Patent number: 7415306Abstract: The present invention provides a transdermal delivery system for hydrophilic anti-emetic agents and methods of using thereof. The system includes an anti-emetic hydrophilic adhesive composition of a hydrophilic polymer and hydrophilic anti-emetic agent, a patch containing at least one hydrophilic layer of the composition, and an apparatus that generates hydrophilic micro-channels in skin of a subject using the patch or composition. The system preferably avoids the use of penetration enhancers and is particularly useful for transdermal delivery of hydrophilic anti-emetic agents.Type: GrantFiled: April 27, 2005Date of Patent: August 19, 2008Assignee: TransPharma Medical Ltd.Inventors: Galit Levin, Dorit Daniel
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Patent number: 7395111Abstract: The present invention provides a system for transdermal delivery of water insoluble drugs and methods using the same. The system includes a pharmaceutical composition of a water insoluble drug and a carrier molecule that enhances the solubility of the drug in aqueous solution, a medical patch containing the same and an apparatus that generates hydrophilic micro-channels in an area of skin of a subject using the composition or patch. The system preferably avoids the use of penetration enhancers and is particularly useful for transdermal delivery of steroids.Type: GrantFiled: April 27, 2005Date of Patent: July 1, 2008Assignee: TransPharma Medical Ltd.Inventors: Galit Levin, Meir Stern, Dorit Daniel
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Publication number: 20060057208Abstract: Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution is coated onto at least a portion of the internal cavity, and acts as a slow-release drug delivery system.Type: ApplicationFiled: September 16, 2004Publication date: March 16, 2006Inventors: Asher Holzer, Dorit Daniel, Eran Hirszowicz
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Publication number: 20050287217Abstract: The present invention provides a system for transdermal delivery of water insoluble drugs and methods using the same. The system includes a pharmaceutical composition of a water insoluble drug and a carrier molecule that enhances the solubility of the drug in aqueous solution, a medical patch containing the same and an apparatus that generates hydrophilic micro-channels in an area of skin of a subject using the composition or patch. The system preferably avoids the use of penetration enhancers and is particularly useful for transdermal delivery of steroids.Type: ApplicationFiled: April 27, 2005Publication date: December 29, 2005Inventors: Galit Levin, Meir Stern, Dorit Daniel