Patents by Inventor Dorota A. Bulik

Dorota A. Bulik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for the Diagnosis and Treatment of Kawasaki Disease
    Publication number: 20210116462
    Abstract: The present invention relates to the determination of levels or expression of particular biomarkers in biological samples which can be utilized to diagnose, prognose, and treat Kawasaki disease in subjects, and further to select subjects who would benefit from a Kawasaki disease therapy other than, or in addition to, IVIG treatment. Accordingly, the present invention encompasses methods and compositions that utilize these biomarkers for the diagnosis, prognosis, and treatment of Kawasaki disease.
    Type: Application
    Filed: April 6, 2020
    Publication date: April 22, 2021
    Inventors: Dorota A. Bulik, Carlos J. Bosques, Jay Duffner, Leona E. Ling, Hetal Sarvaiya
  • Modified glycoproteins
    Patent number: 10377832
    Abstract: Modified glycoproteins, and methods of making and using such modified glycoproteins, are described.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: August 13, 2019
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Nathaniel Washburn, James Meador, III, Carlos J. Bosques, Dorota A. Bulik, Naveen Bhatnagar, Julia Brown, Lynn Markowitz, Sathya Prabbhakar
  • Modified glycoproteins
    Patent number: 10377809
    Abstract: Sulfated glycoproteins, and methods of making and using such sulfated glycoproteins, are described.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: August 13, 2019
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Dorota A. Bulik, Carlos J. Bosques, Brian Edward Collins, Maurice Gaston Hains, Nathaniel J. Washburn, James Meador, Sean Smith, Naveen Bhatnagar
  • High mannose glycans
    Patent number: 9921210
    Abstract: Methods and compositions related to high mannose glycans are described.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: March 20, 2018
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Brian Edward Collins, Jay Duffner, Carlos J. Bosques, Dorota A. Bulik, James Myette, James Meador
  • MODIFIED GLYCOPROTEINS
    Publication number: 20170349662
    Abstract: Modified glycoproteins, and methods of making and using such modified glycoproteins, are described.
    Type: Application
    Filed: April 25, 2017
    Publication date: December 7, 2017
    Inventors: Nathaniel Washburn, James Meador, III, Carlos J. Bosques, Dorota A. Bulik, Naveen Bhatnagar, Julia Brown, Lynn Markowitz, Sathya Prabbhakar
  • MODIFIED GLYCOPROTEINS
    Publication number: 20170247426
    Abstract: Sulfated glycoproteins, and methods of making and using such sulfated glycoproteins, are described.
    Type: Application
    Filed: April 10, 2017
    Publication date: August 31, 2017
    Inventors: Dorota A. Bulik, Carlos J. Bosques, Brian Edward Collins, Maurice Gaston Hains, Nathaniel J. Washburn, James Meador, Sean Smith, Naveen Bhatnagar
  • Modified glycoproteins
    Patent number: 9663581
    Abstract: Modified glycoproteins, and methods of making and using such modified glycoproteins, are described.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: May 30, 2017
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Nathaniel Washburn, James Meador, III, Carlos J. Bosques, Dorota A. Bulik, Naveen Bhatnagar, Julia Brown, Lynn Markowitz, Sathya Prabbhakar
  • Modified glycoproteins
    Patent number: 9650433
    Abstract: Sulfated glycoproteins, and methods of making and using such sulfated glycoproteins, are described.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: May 16, 2017
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Dorota A. Bulik, Carlos J. Bosques, Brian Edward Collins, Maurice Gaston Hains, Nathaniel J. Washburn, James Meador, Sean Smith, Naveen Bhatnagar
  • METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF KAWASAKI DISEASE
    Publication number: 20170052200
    Abstract: The present invention relates to the determination of levels or expression of particular biomarkers in biological samples which can be utilized to diagnose, prognose, and treat Kawasaki disease in subjects, and further to select subjects who would benefit from a Kawasaki disease therapy other than, or in addition to, IVIG treatment. Accordingly, the present invention encompasses methods and compositions that utilize these biomarkers for the diagnosis, prognosis, and treatment of Kawasaki disease.
    Type: Application
    Filed: May 1, 2015
    Publication date: February 23, 2017
    Inventors: Dorota A. BULIK, Jay DUFFNER, Leona E. LING, Hetal SARVAIYA, Carlos J. BOSQUES
  • DEFINED GLYCOPROTEIN PRODUCTS AND RELATED METHODS
    Publication number: 20160097074
    Abstract: The invention provides methods, databases and systems for making glycoprotein products having defined properties.
    Type: Application
    Filed: October 14, 2015
    Publication date: April 7, 2016
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Brian Edward Collins, Carlos J. Bosques, Lakshmanan Thiruneelakantapillai, Dorota A. Bulik, Ian C. Parsons, Zachary Shriver, Rajeev Chillakuru, Ganesh Kaundinya
  • MODIFIED GLYCOPROTEINS
    Publication number: 20150299331
    Abstract: Modified glycoproteins, and methods of making and using such modified glycoproteins, are described.
    Type: Application
    Filed: April 24, 2013
    Publication date: October 22, 2015
    Inventors: Nathaniel Washburn, James Meador, III, Carlos J. Bosques, Dorota A. Bulik, Naveen Bhatnagar, Julia Brown, Lynn Markowitz, Sathya Prabbhakar
  • GLYCOPROTEIN PREPARATIONS
    Publication number: 20150252108
    Abstract: Preparations of glycoproteins, e.g., therapeutic preparations of glycoproteins, having altered levels of affinity for Fc? receptors relative to reference glycoprotein preparations, and methods of making and methods of using such preparations, are described.
    Type: Application
    Filed: September 25, 2013
    Publication date: September 10, 2015
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Nathaniel J. Washburn, Jonathan C. Lansing, Carlos J. Bosques, Naveen Bhatnagar, Dorota A. Bulik, Lynn Markowitz, Sandra Sipsey
  • Characterization of N-glycans using exoglycosidases
    Patent number: 9029081
    Abstract: The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: May 12, 2015
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Dorota A. Bulik, Carlos J. Bosques, Lakshmanan Thiruneelakantapillai, Brian Edward Collins
  • MODIFIED GLYCOPROTEINS
    Publication number: 20140112910
    Abstract: Sulfated glycoproteins, and methods of making and using such sulfated glycoproteins, are described.
    Type: Application
    Filed: May 18, 2012
    Publication date: April 24, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Dorota A. Bulik, Carlos J. Bosques, Brian Edward Collins, Maurice Gaston Hains, Nathaniel J. Washburn, James Meador, Sean Smith, Naveen Bhatnagar
  • HIGH MANNOSE GLYCANS
    Publication number: 20130231255
    Abstract: Methods and compositions related to high mannose glycans are described.
    Type: Application
    Filed: April 7, 2011
    Publication date: September 5, 2013
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Brian Edward Collins, Jay Duffner, Carlos J. Bosques, Dorota A. Bulik, James Myette, James Meador
  • Characterization of -glycans using exoglycosidases
    Patent number: 8361705
    Abstract: The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially.
    Type: Grant
    Filed: April 15, 2008
    Date of Patent: January 29, 2013
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Dorota A. Bulik, Carlos J. Bosques, Lakshmanan Thiruneelakantapillai, Brian Edward Collins
  • PRODUCTION OF GLYCOPROTEINS
    Publication number: 20120329709
    Abstract: The present invention provides methods and materials by which glycosylation of glycoproteins can be regulated. Methods include the monitoring and regulation of parameters such that a glycoprotein having a desired product quality is obtained.
    Type: Application
    Filed: May 25, 2010
    Publication date: December 27, 2012
    Inventors: Brian Edward Collins, Tiffany Guo, Lakshmanan Thiruneelakantapillai, Kevin Millea, Dorota A. Bulik
  • Methods related to cell surface glycosylation
    Patent number: 8338088
    Abstract: The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
    Type: Grant
    Filed: April 15, 2008
    Date of Patent: December 25, 2012
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Brian Edward Collins, Carlos J. Bosques, Xiangping Zhu, Dorota A. Bulik, Lakshmanan Thiruneelakantapillai, Ian Christopher Parsons, Zachary Shriver, Rajeev Chillakuru, Ganesh Venkataraman
  • METHODS OF MODULATING FUCOSYLATION OF GLYCOPROTEINS
    Publication number: 20120277165
    Abstract: The present invention provides methods and materials useful for monitoring and regulating the glycosylation of glycoproteins that are recombinantly produced from cells. In particular, methods are provided for monitoring and regulating levels of cellular indicators which affect the level of fucosylation produced by cells.
    Type: Application
    Filed: June 4, 2010
    Publication date: November 1, 2012
    Inventors: Brian E. Collins, Lakshmanan Thiruneelakantapillai, Dorota A. Bulik, Kevin Millea
  • METHODS RELATED TO CELL SURFACE GLYCOSYLATION
    Publication number: 20100196940
    Abstract: The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
    Type: Application
    Filed: April 15, 2008
    Publication date: August 5, 2010
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Brian Edward Collins, Carlos J. Bosques, Xiangping Zhu, Dorota A. Bulik, Lakshmanan Thiruneelakantapillai, Ian Christopher Parsons, Zachary Shriver, Rajeev Chillakuru, Ganesh Venkataraman